Navigation Links
Genomic assay as an alternative to animal testing
Date:6/14/2013

The method developed by the group in Lund is based on human cells grown in a laboratory. The cells are exposed to a chemical and then parts of their genetic content are filtered out and transferred to a microchip.

"Using the chip, we can then read which genes reacted to the chemical and how they reacted. This provides a 'signature' of gene expression that shows whether the substance is allergenic", explains Malin Lindstedt.

The test has now been submitted for prevalidation to the EU agency that approves alternatives to animal testing. In the future, it could also be used in connection with the EU's chemicals legislation, REACH, which requires extensive testing of new chemicals. Under the rules in REACH, tens of thousands of chemicals will have to be tested, meaning many animal experiments to investigate the substances' potential allergy risk alone is estimated to require over 800 000 animals.

For allergy tests, guinea pigs and mice are the most commonly used animals. With guinea pigs, the test substance is injected under the skin to see if it produces redness, swelling or blisters. With mice, the substance is injected into the skin of the ear. The mice are put down a few days later so that the immunological reaction in their lymph nodes can be analysed.

Using animal experiments is ethically problematic. However, it also takes a lot of time and is therefore expensive. What is more, the results are not always reliable.

"The tests we have developed are more relevant for our health because they are based on human cells. Animal tests sometimes produce misleading results, which is only discovered afterwards once a substance has already caused allergic reactions", says Malin Lindstedt.

The Lund group started by developing a test for contact allergies. Subsequently, another test has been developed that can determine which substances could produce respiratory allergies, which often affect those who work in the chemicals industry.

"We are also developing the technology itself, to make it simpler and easier to manage. It will soon be possible to screen hundreds of chemicals at a time, which will be much, much quicker and cheaper", says Malin Lindstedt.


'/>"/>

Contact: Malin Lindstedt
Malin.Lindstedt@immun.lth.se
46-462-229-256
Lund University
Source:Eurekalert

Related medicine news :

1. Laboratory Automation Market: 2017 Equipment & Software, Drug Discovery, Clinical Diagnostics, Genomics & Proteomics Analysis in New Research Reports at RnRMarketResearch
2. Mayo Clinic genomic analysis lends insight to prostate cancer
3. Why We Cant Wait: Conference to Eliminate Health Disparities in Genomic Medicine
4. Large genomic study identifies endometrial cancer subtypes, treatment opportunities
5. Genomic detectives crack the case of the missing heritability
6. The science of uncertainty in genomic medicine
7. Deep genomic analysis identifies a micro RNA opponent for ovarian cancer
8. Nurses at forefront of genomics in health care
9. Genomic sequencing identifies mutant drivers of common brain tumor
10. Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
11. When will genomic research translate into clinical care -- and at what cost?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... City, Utah (PRWEB) , ... February 13, 2016 , ... When an Au Pair ... Parents aren’t always sure what they are in for and they are often worried things ... more than they were hoping for. This year’s Au Pair of the Year winner’s all ...
(Date:2/12/2016)... San Antonio, TX (PRWEB) , ... February 12, 2016 , ... ... of love, as expressed in Blue SKies Buddha, the biography of Rama - Dr. ... in fact a love story, the love of a Buddhist teacher for teaching and ...
(Date:2/12/2016)... ... ... Trends: , Back to the Future , Feb. 25, 2016 — 11:00 a.m. – 12:30 ... don’t learn from history are doomed to repeat it.” , An analysis of CDRH’s enforcement ... that takes time. , Take a close look at the warning letters the agency ...
(Date:2/12/2016)... ... ... Coco Libre, the maker of coconut water beverages with a purpose, is ... Coco Libre will offer musicians and celebrities the company’s signature Organic Coconut Water, a ... suite, held this year at the W Hollywood Hotel, has become a pre-show “must” ...
(Date:2/12/2016)... ... , ... Every winter, someone is killed, injured or loses a home in ... part of the Allegheny Health Network, has partnered with Etna Volunteer Fire Department, ... Space” campaign. , “Space Heaters Need Space” aims to bring awareness to ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Feb. 12, 2016 /PRNewswire/ - Demers Ambulances announces its first delivery ... Okaloosa County Emergency Medical Services (EMS) ... and one LT2 van. Quality Emergency Vehicles in ... for the sale.  This is the latest in Demers, ongoing ... Vice President at Demers. --> Benoit LaFortune , ...
(Date:2/12/2016)... ALISO VIEJO , Kalifornien, 12. Februar 2016 ... es mit der Aufnahme von Patienten für eine ... Embolisation von Aneurysmen („WEB") speziell für die Behandlung ... Laurent Spelle , MD, Leiter der Neuroradiologie an ... , Frankreich, und Hauptprüfarzt der CLARYS-Studie hat den ...
(Date:2/12/2016)... and SEOUL, South Korea , ... and Macrogen, Inc. today announced they will form ... procedures for precision medicine in cancer. The goal ... DEPArray™ digital-sorting technology with Macrogen,s high-throughput Next Generation ... under the Clinical Laboratory Improvement Amendments (CLIA) of ...
Breaking Medicine Technology: