Navigation Links
Genomic assay as an alternative to animal testing
Date:6/14/2013

The method developed by the group in Lund is based on human cells grown in a laboratory. The cells are exposed to a chemical and then parts of their genetic content are filtered out and transferred to a microchip.

"Using the chip, we can then read which genes reacted to the chemical and how they reacted. This provides a 'signature' of gene expression that shows whether the substance is allergenic", explains Malin Lindstedt.

The test has now been submitted for prevalidation to the EU agency that approves alternatives to animal testing. In the future, it could also be used in connection with the EU's chemicals legislation, REACH, which requires extensive testing of new chemicals. Under the rules in REACH, tens of thousands of chemicals will have to be tested, meaning many animal experiments to investigate the substances' potential allergy risk alone is estimated to require over 800 000 animals.

For allergy tests, guinea pigs and mice are the most commonly used animals. With guinea pigs, the test substance is injected under the skin to see if it produces redness, swelling or blisters. With mice, the substance is injected into the skin of the ear. The mice are put down a few days later so that the immunological reaction in their lymph nodes can be analysed.

Using animal experiments is ethically problematic. However, it also takes a lot of time and is therefore expensive. What is more, the results are not always reliable.

"The tests we have developed are more relevant for our health because they are based on human cells. Animal tests sometimes produce misleading results, which is only discovered afterwards once a substance has already caused allergic reactions", says Malin Lindstedt.

The Lund group started by developing a test for contact allergies. Subsequently, another test has been developed that can determine which substances could produce respiratory allergies, which often affect those who work in the chemicals industry.

"We are als
'/>"/>

Contact: Malin Lindstedt
Malin.Lindstedt@immun.lth.se
46-462-229-256
Lund University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Laboratory Automation Market: 2017 Equipment & Software, Drug Discovery, Clinical Diagnostics, Genomics & Proteomics Analysis in New Research Reports at RnRMarketResearch
2. Mayo Clinic genomic analysis lends insight to prostate cancer
3. Why We Cant Wait: Conference to Eliminate Health Disparities in Genomic Medicine
4. Large genomic study identifies endometrial cancer subtypes, treatment opportunities
5. Genomic detectives crack the case of the missing heritability
6. The science of uncertainty in genomic medicine
7. Deep genomic analysis identifies a micro RNA opponent for ovarian cancer
8. Nurses at forefront of genomics in health care
9. Genomic sequencing identifies mutant drivers of common brain tumor
10. Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
11. When will genomic research translate into clinical care -- and at what cost?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Men who show signs of chronic inflammation in non-cancerous ... actually having prostate cancer than those with no inflammation, ... researchers from the Johns Hopkins Kimmel Cancer Center. , ... stronger for men with so-called high-grade prostate cancer ... indicating the presence of the most aggressive and ...
(Date:4/17/2014)... issue of Experimental Biology and Medicine ... Gaskins and Paul Kenis in the Institute of ... University of Illinois Urbana-Champaign describe their recent work ... a variety of cell functions including energy metabolism, ... roles in regulating normal cellular behavior, redox status ...
(Date:4/17/2014)... biology team has created a new technology for ... could travel the body and selectively target cancer ... biological devices that monitor and modify human physiology ... However, no existing technology enabled bioengineers to build ... and respond in a customized fashion. , "The ...
(Date:4/17/2014)... affects about one in five infants in the United ... the first several months after birth. Research into probiotic ... however, the April 1, 2014 issue of the ... a study, "Probiotics and Infant Colic," concluding that the ... infant colic did not reduce crying or fussing ...
(Date:4/17/2014)... potential to ward off depression among retirees, particularly among ... in The Journals of Gerontology, Series B: ... article " Internet Use and Depression Among Retired Older ... the authors report that Internet use reduced the probability ... study sample. , Late-life depression affects between 5 ...
Breaking Medicine News(10 mins):Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Building 'smart' cell-based therapies 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:Internet use may cut retirees' depression 2
... For the first time, scientists have demonstrated that stem ... of potential to become specialized cell types, which suggests ... of diseases and conditions than scientists originally thought. ... Publishing Group, the research teams of Anthony Atala, M.D., ...
... The Merriman Good Life ... raising awareness of the general public to the value of pets visiting residents of nursing homes ... ... the Daisy Project. The Daisy Project is aimed at raising awareness of the general public ...
... ... DentaSOAK®, a professional dental cleaner powerful enough to kill more than 99% of infection-causing ... ... Oklahoma State University found that mouthguards used regularly are highly contaminated with bacteria and ...
... by many young children in child care settings doubles the ... home-based settings watching significantly more on average than those in ... screen time in child care settings in more than 20 ... child care programs in four states, and was guided by ...
... November 18, 2009 -- When people have malaria, they are ... saliva of a mosquito, infect cells in the liver, and ... the parasites replicate and also begin to expose adhesive proteins ... the cells in the bloodstream. Experiments show that infected ...
... control, expert says , SUNDAY, Nov. 22 (HealthDay News) ... a seemingly endless buffet of food temptation. While some ... deny themselves any holiday treats. , But there are ... Julie Redfern, manager of Nutrition Consult Services at Brigham ...
Cached Medicine News:Health News:New research shows versatility of amniotic fluid stem cells 2Health News:Daisy Project Seeks To Increase Pet Visitation In Nursing Homes 2Health News:DentaSOAK Dental Cleaner Reduces Infection Risk Linked to Mouthguards 2Health News:Daycare may double TV time for young children, study finds 2Health News:Daycare may double TV time for young children, study finds 3Health News:Daycare may double TV time for young children, study finds 4Health News:Measuring and modeling blood flow in malaria 2Health News:Go Healthy, Not Hungry for Holiday Eating 2
(Date:1/14/2014)... 2014 The Brandeis Medical Center, led by Dr. Emmanuel ... and affordable laser tattoo removal experience with the advanced Astanza Duality ... providing high quality cosmetic services with cutting edge medical technology and ... Southern California has seen a dramatic increase in the ...
(Date:1/14/2014)... Jan. 14, 2014 /PRNewswire-iReach/ -- Acumed,s new SLIC Screw ... with accompanying instrumentation to place and insert the screw ... soft tissue (e.g. ligament) repair or reconstruction as it ... (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) ...
(Date:1/14/2014)... Minn. , Jan. 14, 2014   NuAire , a manufacturer ... to agreement with Hitachi Koki of Japan ... in North America . NuAire will utilize its ... and Canada to offer assistance in ...
Breaking Medicine Technology:Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3NuAire announces sales and service of Hitachi Koki centrifuges in North America 2
... Stanley Global Healthcare Conference -- SHENZHEN, China, Aug. 27 /PRNewswire-Asia-FirstCall/ -- ... ... ... = ,; var first_result; // Results are keyed by longUrl, so we need to grab the ...
... Orexigen® Therapeutics, Inc. (Nasdaq: OREX ), a biopharmaceutical ... on August 25, 2010 the Compensation Committee of the Company,s ... to purchase a total of 10,000 shares of common stock ... options are intended to be incentive stock options to the ...
Cached Medicine Technology:Mindray Medical to Present at the Morgan Stanley Global Healthcare Conference 2Mindray Medical to Present at the Morgan Stanley Global Healthcare Conference 3Mindray Medical to Present at the Morgan Stanley Global Healthcare Conference 4Mindray Medical to Present at the Morgan Stanley Global Healthcare Conference 5Mindray Medical to Present at the Morgan Stanley Global Healthcare Conference 6Orexigen(R) Therapeutics Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4) 2
... CycloPhotocoagulation (ECP) is a surgical approach to ... visualized laser application. The ciliary body (which ... surgeon, from the anterior or posterior segment, ... target tissues are easily and accurately identified ...
... (ECP) is a surgical approach to glaucoma ... laser application. The ciliary body (which produces ... from the anterior or posterior segment, through ... tissues are easily and accurately identified utilizing ...
... Craftsmanship have produced the finest ... Ocutek® now makes them available ... the coveted Meisterbrief certificate, which ... qualified to become Ocutek instrument ...
... is a surgical approach to glaucoma management ... application. The ciliary body (which produces aqueous ... the anterior or posterior segment, through the ... are easily and accurately identified utilizing endoscopy. ...
Medicine Products: