Navigation Links
Genomic assay as an alternative to animal testing
Date:6/14/2013

The method developed by the group in Lund is based on human cells grown in a laboratory. The cells are exposed to a chemical and then parts of their genetic content are filtered out and transferred to a microchip.

"Using the chip, we can then read which genes reacted to the chemical and how they reacted. This provides a 'signature' of gene expression that shows whether the substance is allergenic", explains Malin Lindstedt.

The test has now been submitted for prevalidation to the EU agency that approves alternatives to animal testing. In the future, it could also be used in connection with the EU's chemicals legislation, REACH, which requires extensive testing of new chemicals. Under the rules in REACH, tens of thousands of chemicals will have to be tested, meaning many animal experiments to investigate the substances' potential allergy risk alone is estimated to require over 800 000 animals.

For allergy tests, guinea pigs and mice are the most commonly used animals. With guinea pigs, the test substance is injected under the skin to see if it produces redness, swelling or blisters. With mice, the substance is injected into the skin of the ear. The mice are put down a few days later so that the immunological reaction in their lymph nodes can be analysed.

Using animal experiments is ethically problematic. However, it also takes a lot of time and is therefore expensive. What is more, the results are not always reliable.

"The tests we have developed are more relevant for our health because they are based on human cells. Animal tests sometimes produce misleading results, which is only discovered afterwards once a substance has already caused allergic reactions", says Malin Lindstedt.

The Lund group started by developing a test for contact allergies. Subsequently, another test has been developed that can determine which substances could produce respiratory allergies, which often affect those who work in the chemicals industry.

"We are also developing the technology itself, to make it simpler and easier to manage. It will soon be possible to screen hundreds of chemicals at a time, which will be much, much quicker and cheaper", says Malin Lindstedt.


'/>"/>

Contact: Malin Lindstedt
Malin.Lindstedt@immun.lth.se
46-462-229-256
Lund University
Source:Eurekalert

Related medicine news :

1. Laboratory Automation Market: 2017 Equipment & Software, Drug Discovery, Clinical Diagnostics, Genomics & Proteomics Analysis in New Research Reports at RnRMarketResearch
2. Mayo Clinic genomic analysis lends insight to prostate cancer
3. Why We Cant Wait: Conference to Eliminate Health Disparities in Genomic Medicine
4. Large genomic study identifies endometrial cancer subtypes, treatment opportunities
5. Genomic detectives crack the case of the missing heritability
6. The science of uncertainty in genomic medicine
7. Deep genomic analysis identifies a micro RNA opponent for ovarian cancer
8. Nurses at forefront of genomics in health care
9. Genomic sequencing identifies mutant drivers of common brain tumor
10. Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
11. When will genomic research translate into clinical care -- and at what cost?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... “Mary Magdalene: Grace is ... life of the woman who witnessed Jesus Christ firsthand. “Mary Magdalene: Grace is Greater ... spent her career as an educator interacting with countless women who had little knowledge ...
(Date:1/20/2017)... ... 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went on ... of published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age of ... 19 years of age, he joined the Navy and got married right out of boot ...
(Date:1/20/2017)... ... January 20, 2017 , ... D ... Expiratory Pressure (OPEP) device, was featured in a study indicating superior performance against ... FAARC, “Analysis of Three Oscillating Positive Expiratory Pressure Devices During Simulated Breathing“ ...
(Date:1/20/2017)... ... ... and enchanting tale that teaches children the true meaning of Christmas. “Journey to Christmas” is ... a devoted woman of faith. , “Becoming a parent changes you. In my case, ... for years, but actually doing it might have been a while in coming if it ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Land of More ... to the issue of world hunger, and shares the simple and achievable answer. “The ... husband and member of the Fairview Missionary Church in Angola, Indiana where he works ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... NEW YORK , Jan. 19, 2017 /PRNewswire/ ... reach USD 233.7 billion by 2025, according to ... The market is anticipated to be predominantly driven ... companies, resulting into the large-scale production of new ... widen the influx of drugs at an unprecedented ...
(Date:1/19/2017)... The Global Therapy Partnering Terms and Agreements ... deals and agreements entered into by the world,s leading ... Top deals by value - Deals listed by company ... The report provides understanding and access to the partnering ... healthcare companies. The report provides an analysis of ...
(Date:1/19/2017)... and Webcast to Follow Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... the fourth quarter of 2016 on Wednesday, February 15, 2017, after ... ... on Wednesday, February 15, 2017, during which management will discuss the ... activities. To participate in the conference call, please dial 1-888-771-4371 (domestic) ...
Breaking Medicine Technology: