Navigation Links
Genomic assay as an alternative to animal testing
Date:6/14/2013

The method developed by the group in Lund is based on human cells grown in a laboratory. The cells are exposed to a chemical and then parts of their genetic content are filtered out and transferred to a microchip.

"Using the chip, we can then read which genes reacted to the chemical and how they reacted. This provides a 'signature' of gene expression that shows whether the substance is allergenic", explains Malin Lindstedt.

The test has now been submitted for prevalidation to the EU agency that approves alternatives to animal testing. In the future, it could also be used in connection with the EU's chemicals legislation, REACH, which requires extensive testing of new chemicals. Under the rules in REACH, tens of thousands of chemicals will have to be tested, meaning many animal experiments to investigate the substances' potential allergy risk alone is estimated to require over 800 000 animals.

For allergy tests, guinea pigs and mice are the most commonly used animals. With guinea pigs, the test substance is injected under the skin to see if it produces redness, swelling or blisters. With mice, the substance is injected into the skin of the ear. The mice are put down a few days later so that the immunological reaction in their lymph nodes can be analysed.

Using animal experiments is ethically problematic. However, it also takes a lot of time and is therefore expensive. What is more, the results are not always reliable.

"The tests we have developed are more relevant for our health because they are based on human cells. Animal tests sometimes produce misleading results, which is only discovered afterwards once a substance has already caused allergic reactions", says Malin Lindstedt.

The Lund group started by developing a test for contact allergies. Subsequently, another test has been developed that can determine which substances could produce respiratory allergies, which often affect those who work in the chemicals industry.

"We are also developing the technology itself, to make it simpler and easier to manage. It will soon be possible to screen hundreds of chemicals at a time, which will be much, much quicker and cheaper", says Malin Lindstedt.


'/>"/>

Contact: Malin Lindstedt
Malin.Lindstedt@immun.lth.se
46-462-229-256
Lund University
Source:Eurekalert

Related medicine news :

1. Laboratory Automation Market: 2017 Equipment & Software, Drug Discovery, Clinical Diagnostics, Genomics & Proteomics Analysis in New Research Reports at RnRMarketResearch
2. Mayo Clinic genomic analysis lends insight to prostate cancer
3. Why We Cant Wait: Conference to Eliminate Health Disparities in Genomic Medicine
4. Large genomic study identifies endometrial cancer subtypes, treatment opportunities
5. Genomic detectives crack the case of the missing heritability
6. The science of uncertainty in genomic medicine
7. Deep genomic analysis identifies a micro RNA opponent for ovarian cancer
8. Nurses at forefront of genomics in health care
9. Genomic sequencing identifies mutant drivers of common brain tumor
10. Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
11. When will genomic research translate into clinical care -- and at what cost?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 19, 2017 , ... “Congratulations! It's A Boy! ... children to both their parents and God. “Congratulations! It's A Boy! God’s Gift: A ... a couple from Long Island, New York. , Published by Christian Faith Publishing, Dale ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... specialized asset-light logistics provider of complex transport solutions for mission-critical and non-discretionary ... Unitrans International Corporation, a division of Roadrunner Transportation Systems, Inc. (NYSE: RRTS). ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... handheld devices. Through an educational webinar, they will present the line of epMotion ... to learn how easy you can automate everyday pipetting tasks. , Ideal for ...
(Date:8/18/2017)... TX (PRWEB) , ... August 18, 2017 , ... ... assistance and financial planning services to communities in east Texas, is launching a ... Brain Tumor Foundation. , Founded in 1991, the Pediatric Brain Tumor Foundation (PBTF) ...
(Date:8/18/2017)... ... 2017 , ... The Golseth Agency, a Texas based insurance management and financial ... regional charity campaign organized to provide support to Christina Upchurch and her two children ... and her children returned from out of town to find her husband passed away ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... HIGH POINT, N.C. , Aug. 15, 2017  Axium Pharmaceuticals Inc., ... epilepsy is rumored to be in the beginning stages of an IPO. ... billion annually on epilepsy medications with the average cost of a prescription ... ... Another staggering figure is ...
(Date:8/11/2017)... Israel , Aug. 11, 2017 DarioHealth ... with mobile health and big data solutions, today announced ... on Monday, August 14 and host a conference call ... quarter 2017 operating and financial results and its strategy ... will be hosted by Erez Raphael , Chief ...
(Date:8/7/2017)... , Aug. 7, 2017 Insightin ... member acquisition, retention, and engagement, announced the selection ... Strategy and Product Development, effective as of February 2017. ... and technology implementation strategy for our clients. Wood ... experience in consulting and business analytics within the ...
Breaking Medicine Technology: