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Genomic Systems announces 'moratorium on studying and treating terminal cancer has ended'
Date:10/18/2010

PALO ALTO, CA (OCTOBER 15, 2010) Terminal metastatic cancer the presently untreatable cause of the great majority of all cancer deaths has now been effectively treated in three common fatal cancers in mice, according to announced Genomic Systems, citing research published online in the Proceedings of the National Academy of Sciences (PNAS).

Research conducted by Robert J. Debs, M.D., senior scientist at the California Pacific Medical Center Research Institute in collaboration with four other laboratories has shown that a monoclonal antibody targeting a protein called PECAM-1 is effective against this now invariably lethal stage of cancer in mice. This antibody also treats less advanced cancers, as well as the debilitating wasting syndrome that can develop as cancers progress.

Anti-PECAM-1-antibody produces its anti-cancer effects not by binding to tumor cells, but rather by binding to PECAM-1 on the surface of normal endothelial cells that line blood vessels. Because it acts through normal cells rather than directly on cancer cells, it is effective against a variety of different cancer types.

Laboratory testing has now shown anti-PECAM-1-antibody to be effective against colon cancer, breast cancer and melanoma. These are among the most frequently diagnosed fatal cancers in the United States, according to the National Cancer Institute.

"For the first time, preclinical studies provide hope for patients and their physicians that even the terminal stages of cancer do not invariably represent a hopeless situation. Our research has shown that some terminal cancers, as well as the debilitating wasting syndrome that can accompany them can now be treated in mice, said Dr. Debs. "Hopefully, these studies will encourage increased interest in studying terminal cancers, as well as stimulate others to develop additional new therapies that effectively target this most devastating stage of cancer."

The research a
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