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Genomic Profiling of Breast Cancers a Better Treatment Tool
Date:4/1/2008

Findings point to personalized therapies that help predict disease recurrence

TUESDAY, April 1 (HealthDay News) -- Determining the genetic profile of a breast tumor, along with an assessment of a patient's clinical characteristics, can help predict prognosis and guide treatment choices, a Duke University study concludes.

"Our goal is to treat patients on a more individualized basis, matching the right drugs with the right patients," Dr. Anil Potti, an oncologist and researcher in the Duke Comprehensive Cancer Center and Duke's Institute for Genome Sciences & Policy, said in a prepared statement.

"The combination of these two methods, one of which uses the clinical description of a patient's breast cancer and the other which looks at the gene expression at a molecular level in a patient's tumor, may allow us to do that with unprecedented accuracy. This represents a robust approach to personalizing treatment strategies in patients suffering from breast cancer," Potti said.

The team examined almost 1,000 breast tumors and corresponding patient data and used a computerized system called Adjuvant! to assess clinical characteristics and make predictions of recurrence. The researchers then compared gene expression in the tumor samples and were able to identify specific genomic patterns among patients with aggressive cancers and those with cancers less likely to recur.

"We knew from previous studies that Adjuvant! tends to overestimate disease recurrence in younger patients. We hypothesized that genomic profiling could be a complementary tool that would more precisely define clinical outcomes and could also help to aid in selecting the right drug for a given patient," Potti said.

Not only did their method identify patients at high risk for cancer recurrence, it specified the degree of that risk. For example, they could predict that a patient had a 90 percent risk of recurrence.

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