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Genomic Health Announces Study Establishing the Utility of Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated with Aromatase Inhibitors
Date:12/13/2008

triple-negative breast cancer, a subtype that does not express genes for estrogen receptor (ER), progesterone receptor (PR) or HER2. Triple negative breast cancer is considered to be more aggressive and difficult to treat than hormone receptor-positive or HER2- positive breast cancers. These results need to be confirmed with future trials. * On Friday, December 12 researchers from Genomic Health presented results from a study that demonstrated quantitative RT-PCR analysis is possible in ductal carcinoma in situ (DCIS) that is adjacent to invasive ductal carcinoma (IDC). Of the 30 ER-positive breast cancer tumor samples that were identified, 90 percent had sufficient RNA for Oncotype DX analysis, after separating the DCIS and IDC tissues. While DCIS adjacent to invasive breast cancer demonstrated similar quantitative biology for the genes evaluated in the Oncotype DX assay, future studies to evaluate Oncotype DX and recurrence rates in DCIS are needed. * A separate study, also presented on Friday, December 12, found that multiple single nucleotide polymorphisms (SNPs) in the genes that encode ER were not associated with the level of ER expression in breast cancer, suggesting that differences in ER expression between individual tumors are likely a result of factors other than inherited gene mutations.

About Oncotype DX(R)

Oncotype DX is the first and only multi-gene expression test commercially available that has clinical evidence validating its ability to predict the likelihood of chemotherapy benefit as well as recurrence in early-stage breast cancer. Additionally, the test report provides quantitative scores for certain individual genes. Oncotype DX has been extensively evaluated in eleven clinical studies involving
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SOURCE Genomic Health, Inc.
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