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Genomic Health Announces Study Establishing the Utility of Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated with Aromatase Inhibitors
Date:12/13/2008

ad spread to the lymph nodes (0 nodes, 1-3 nodes and more than 4 nodes). Researchers, with support from the UK's leading breast cancer charity, Breakthrough Breast Cancer, and AstraZeneca, collected tumor blocks, mainly from patients in the United Kingdom, and tested the significance of adding the Recurrence Score result to a clinical model consisting of age, tumor size, grade and treatment, as well as the Adjuvant! Online risk assessment tool.

The study indicated that the Oncotype DX Recurrence Score (RS) result showed statistically significant prognostic value beyond that provided by Adjuvant! Online in both node-negative (p<0.001) and node-positive (p=0.003) patients. The greater efficacy of anastrozole observed in the parent ATAC trial and the similar hazard ratios for the RS in both treatment arms from this study suggests a lower risk of recurrence in patients treated with aromatase inhibitors. In addition, for any RS result, the likelihood of distant recurrence increases with the number of positive nodes.

"This study is the largest that Genomic Health has conducted to date, reinforcing our commitment to continue adding value to the Oncotype DX breast cancer assay by studying additional patient populations and treatment regimens relevant to current clinical practice," said Steven Shak, M.D., chief medical officer of Genomic Health. "These results, combined with the suite of clinical evidence that we and our clinical partners generated over the past five years, reinforce our belief that Oncotype DX is an indispensable tool when making treatment decisions for node-negative patients and in certain node-positive patients."

Earlier this week, Genomic Health and research collaborators presented three additional studies. Highlights include:

    *    An oral presentation on Thursday, December 11 suggested that
         GRB7-dependent pathways are potential therapeutic targets for
   
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SOURCE Genomic Health, Inc.
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