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Genomic Health Announces Study Confirming Prognostic Value of Oncotype DX(R) Recurrence Score(R) Result in Japanese Breast Cancer Patients
Date:4/20/2009

ous Recurrence Score(R) was strongly associated with the risk of distant recurrence (p<0.001). In addition, these patients were categorized into Recurrence Score groups based on the standard cutoff points of 18 and 31; 48 percent had a Recurrence Score less than 18, 20 percent had a Recurrence Score between 18 and 30, and 33 percent had a Recurrence Score greater than or equal to 31. The distribution of Recurrence Scores in the Japanese population was similar to that found in previous multicenter studies performed in the United States. Finally, as shown consistently across multiple Oncotype DX studies, the risk of distant recurrence in the group with a Recurrence Score less than 18 (3% at 10 years) was shown to be significantly lower than the group with a Recurrence Score greater than or equal to 31 (25% at 10 years) (p<0.001). A large proportion of breast cancer patients in Japan were identified by the Recurrence Score to have a low likelihood of distant recurrence when treated with tamoxifen alone without chemotherapy.

About Oncotype DX(R)

The Oncotype DX breast cancer assay is the first and only multi-gene expression test commercially available that has clinical evidence validating its ability to predict the likelihood of chemotherapy benefit as well as recurrence in early-stage breast cancer. Additionally, the test report provides quantitative scores for certain individual genes. The Oncotype DX breast cancer assay has been extensively evaluated in eleven clinical studies involving more than 4,000 breast cancer patients, including a large validation study published in The New England Journal of Medicine and a chemotherapy benefit study published in the Journal of Clinical Oncology. As of December 31, 2008, 7,500 physicians have ordered more than 85,000 tests, and both Medicare and private health plans covering approximately 90 percent of U.S. insured lives provi
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SOURCE Genomic Health
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