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Genomic Health Announces Oncotype DX(R) Provides Additional Prognostic Benefit in Patients Assessed With Adjuvant Online
Date:12/15/2007

- Comparison Study Confirms Oncotype DX Recurrence Score Result Has

Strongest Association with Breast Cancer Recurrence -

SAN ANTONIO, Dec. 15 /PRNewswire-FirstCall/ -- Genomic Health, Inc. (Nasdaq: GHDX) today announced positive results from a study showing that the Oncotype DX Recurrence Score(TM) provides additional prognostic information in patients with early-stage breast cancer beyond that derived from Adjuvant Online, an online tool that evaluates clinical variables to help physicians and patients assess the risks and benefits of getting additional therapy after surgery. Oncotype DX(R) measures the expression of 21 genes of an individual tumor to generate a Recurrence Score result that quantifies the likelihood of recurrence and the magnitude of chemotherapy benefit for a large portion of early-stage breast cancer patients. The results of the research were presented orally today at the 30th Annual San Antonio Breast Cancer Symposium.

"This study shows the significant added benefit of genomic analysis with Oncotype DX, when used in conjunction with the traditional clinical variables as measured by Adjuvant Online," said Steven Shak, M.D., chief medical officer of Genomic Health. "These results, combined with updated ASCO treatment guidelines now recommending Oncotype DX, clearly demonstrate that Oncotype DX provides critical information for breast cancer treatment planning that is not apparent by examination of clinical variables alone."

The comparison study assessed 465 patients with hormone receptor-positive breast cancer from a previous Eastern Cooperative Oncology Group (ECOG) study, computing both the Adjuvant Online risk estimate and Oncotype DX Recurrence Score result for each patient. The st
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SOURCE Genomic Health, Inc.
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