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Genomic Health Announces Data Confirming Manual Microdissection of Biopsy Cavities Is Essential for Accurate Recurrence Risk Assessment in Early-Stage Breast Cancer Patients
Date:10/9/2009

SAN FRANCISCO, Oct. 9 /PRNewswire-FirstCall/ -- Genomic Health, Inc. (Nasdaq: GHDX) today announced results from a study demonstrating the critical role of manual microdissection to remove all biopsy cavities from breast cancer specimens. Genomic Health's Oncotype DX is the only commercially available breast cancer test that employs manual microdissection following review by a board certified surgical pathologist with breast expertise to predict a patient's benefit from chemotherapy and risk of disease recurrence. This study was discussed in a poster presentation at the ASCO 2009 Breast Cancer Symposium in San Francisco.

Oncotype DX measures the expression of 21 genes of an individual tumor removed during surgery to generate a Recurrence Score result that quantifies the magnitude of chemotherapy benefit and the likelihood of recurrence for early-stage breast cancer patients. The Oncotype DX assay is performed on tumor tissue removed either by core biopsy, a commonly used diagnostic procedure for the initial diagnosis of breast cancer, or by surgery, lumpectomy or mastectomy. Since many tumor specimens removed by lumpectomy or mastectomy contain biopsy cavities researchers conducted this study to determine whether the presence of these cavities impacts gene expression and recurrence risk assessment.

"This analysis confirms that the inclusion of biopsy cavities in breast cancer specimens is associated with significant changes in the expression of individual genes, and can ultimately drive the Recurrence Score result higher," said Theodore Miller, MD, professor of pathology at the University of California San Francisco Medical Center. "The removal of biopsy cavities by manual microdissection is warranted by the study's findings and should be practiced as part of any molecular breast cancer diagnostic plat
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SOURCE Genomic Health, Inc.
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