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Genomes show how Staph bacteria gain resistance to last-line drug
Date:5/22/2012

ty to make a natural antibacterial colonizing factor, which is why they can co-exist with Enterococcus. The study also revealed that CC5 strains make proteins that disrupt a variety of human immune responses and allow the bacteria to flourish, increasing the odds that resistance factors will be transferred from Enterococcus to Staphylococcus bacteria in a mixed infection.

The genomes provided clues as to why person-to-person spread of VRSA has not become common. Without the ability to make or resist the antibacterial colonizing factor, CC5 clade members are at a disadvantage in any encounter with other naturally occurring staph strains that normally live on the skin and that do produce this factor.


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Contact: Anne A. Oplinger
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

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