Navigation Links
Genome-wide study identifies factors that may affect vitamin D levels
Date:6/9/2010

An international research consortium has identified four common gene variants that are associated with blood levels of vitamin D and with an increased risk of vitamin D deficiency. The report from the SUNLIGHT consortium involving investigators from six countries will appear in The Lancet and is receiving early online release.

"We identified four common variants that contributed to the risk for vitamin D deficiency," says Thomas Wang, MD, of the Massachusetts General Hospital (MGH) Heart Center, a co-corresponding author of the Lancet report. "Individuals inheriting several of these risk-associated variants had more than twice the risk of vitamin D deficiency as was seen in those without these variants."

Vitamin D's essential role in musculoskeletal health is well known, and in recent years epidemiologic evidence has suggested that vitamin D deficiency may contribute to conditions like diabetes, cardiovascular disease and some cancers. Naturally produced in the skin in response to sunlight, Vitamin D has been added to many types of food and is available in dietary supplements. But studies have shown that from one third to one half of healthy adults in developed countries have low levels of vitamin D. While reduced sun exposure is clearly associated with lower vitamin D levels, environmental and cultural factors including dietary intake cannot completely account for variations in vitamin levels. The fact that vitamin D status tends to cluster in families suggests a genetic contribution.

The SUNLIGHT (Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits) Consortium involved a research team from the U.S., U.K., Canada, Netherlands, Sweden and Finland who pooled data from 15 epidemiologic studies of almost 32,000 white individuals of European descent. Results of the comprehensive genetic screening were correlated with participants' serum vitamin D levels. Statistically significant associations were found for four common variants, all in genes coding enzymes involved with the synthesis, breakdown or transport of vitamin D. The risk association was independent of geographic or other environmental factors; and the more variants an individual inherited, the greater the risk of vitamin D deficiency.

"It's possible that these results could explain why some people respond well to vitamin D supplements and others don't, but that needs to be studied further since we didn't specifically examine response to supplementation," Wang explains. "We also need to investigate how genetic background can modify response to sunlight, whether these associations are seen in other populations, and if these gene variants have an impact in the chronic diseases that appear to be associated with vitamin D deficiency."


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Related medicine news :

1. Casual Sex Doesnt Cause Emotional Damage: Study
2. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
3. Screening for Spinal Muscular Atrophy Not Cost-Effective: Study
4. New study finds possible source of beta cell destruction that leads to Type 1 diabetes
5. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
6. Risk of stroke lower for recent Ontario immigrants: study
7. Definitive study confirms chemo benefit in postmenopausal breast cancer
8. Experimental stem cell treatment arrests acute lung injury in mice, study shows
9. Violence is part of the job say nurses as study shows only 1 in 6 incidents are reported
10. Controversial Autism Study Retracted by Medical Journal
11. Study Reveals Impact Of Health Insurance On Hispanics' Attitudes Towards Healthcare Providers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... LEXINGTON, Ky. (PRWEB) , ... October 13, 2017 , ... ... MD, MPH to become its next President and Chief Executive Officer, succeeding Dr. James ... and CEO Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Yisrayl Hawkins, ... week that explains one of the most popular and least understood books in the ... cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed it ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), an ... showcase a range of technology and learning solutions at the 68th Annual American ... to be held October 14–18, 2017 at the Mandalay Bay Resort in Las ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
(Date:9/12/2017)... , Sept. 12, 2017  ValGenesis Inc., ... Solutions (VLMS), is pleased to announce the appointment ... member of its Board of Directors and Chairman ... VLMS enables life science companies to manage their ... use of paper in this process. Furthermore, ValGenesis ...
Breaking Medicine Technology: