Navigation Links
Genome-wide atlas of gene enhancers in the brain online
Date:1/31/2013

ncers, sequences of DNA that act to amplify the expression of a specific gene. Characterizing gene enhancers tends to be difficult because an enhancer does not have to be located directly adjacent to the gene it is enhancing, but can in fact be located hundreds of thousands of DNA basepairs away.

"In addition to acting over long distances and being located upstream, downstream or in introns of protein-coding genes, the sequence features of gene enhancers are poorly understood," Visel says. "However, gene-centric studies have provided strong evidence that gene enhancers are critical for normal embryonic development of the brain and have also linked human diseases to perturbed enhancer sequences."

Visel and an international team of researchers met the challenges of systematic identification and functional characterization of gene enhancers in the cerebrum through a combination of ChIP-seq studies and large-scale histological analyses in transgenic mice, in which the activity patterns of human telencephalon enhancers can be studied. ChIP-seq, which stands for "chromatin immunoprecipitation followed by sequencing," is a technique for genome-wide profiling of proteins that interact with DNA.

This combination of approaches enabled Visel and his colleagues to identify over 4,600 candidate embryonic forebrain enhancers. Furthermore, studying mouse embryos they mapped the activity of 145 of these enhancers at high resolution to define where exactly in the developing brain they drive the expression of their respective target genes. The result is a comprehensive, electronically accessible database for investigating the gene regulatory mechanisms of cerebrum development, and for studying the roles of distant-acting enhancers in neurodevelopmental disorders.

"By mapping hundreds of gene enhancer sequences and defining where exactly in the developing brain they are active, our enhancer atlas provides important information to connect non-coding
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Genome-wide scan maps mutations in deadly lung cancers; reveals embryonic gene link
2. Mayo Clinic completes first genome-wide analysis of peripheral T-cell lymphomas
3. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
4. First-ever Allen Brain Atlas Hackathon unleashes big data API to push neuroscience forward
5. Data release from the Allen Institute for Brain Science expands online atlas offerings
6. Should physicians prescribe cognitive enhancers to healthy individuals?
7. Pennsylvania Athletic Trainers’ Society Teams Up with the Brain Injury Association of Pennsylvania to Offer Concussion Management Courses Across the State
8. Jocks beat bookworms on brain test
9. Leading researchers warn of brain drain as scientists struggle to find funding
10. Scientists learn more about how inhibitory brain cells get excited
11. Excessive alcohol use when youre young could have lasting impacts on your brain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genome-wide atlas of gene enhancers in the brain online
(Date:10/25/2014)... October 25, 2014 The ... which verifies IT-accessibility for disabled users by disabled ... logo to Mackin Educational Resources of Burnsville, ... management system and to the Minnesota Alliance for ... "Own Best Medicine" website. Both organizations ...
(Date:10/25/2014)... October 25, 2014 Homeowners that are ... ‘gone bad’ need wonder no more. Clean Crawls ... should watch out for when it comes to insulation ... to the article released by Clean Crawls, can cause ... that any insulation that has deteriorated, become damp, or ...
(Date:10/25/2014)... Limbkeepers® announced today that they will be featured ... Jr, airing 1st QTR 2015 via Discovery Channel. Dates ... will focus on Limbkeepers® non compression knit sleeves, a ... arms, hands, and legs from abrasion, skin tears and ... help reduce injuries, allow for continued daily activities, and ...
(Date:10/25/2014)... 24, 2014 (HealthDay News) -- Not getting the right ... colitis, a new study suggests. Those who sleep ... hours per night may be more prone to developing ... researchers report. The study authors concluded that duration and ... among patients with inflammatory bowel diseases. "Both short ...
(Date:10/25/2014)... Oct. 23, 2014 (HealthDay News) -- Current osteoporosis ... younger postmenopausal women at risk for osteoporosis-related fractures, ... to prevent fractures, we need tools that help ... injuries so that we can target these at-risk ... Crandall, professor of medicine in the division of ...
Breaking Medicine News(10 mins):Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 2Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 3Health News:5 Signs Indicating That Insulation Needs Replacing as Told By Clean Crawls in Recent Article 2Health News:Upcoming Episode of Innovations with Ed Begley, Jr. to Feature Limbkeepers® 2Health News:Sleep Duration Linked to Ulcerative Colitis Risk in Study 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2
... thing in medical research from the field of orthopedics is the use of ... to be true but read on to know more. , ... broken, and you have a cast and you are asked to wait for ... Imagine the amount of trauma and agony you would go through!// ...
... Ohio, the United States of America, have transplanted a bovine jugular ... due to a weakened valve of a vein in his right ... in man to treat varicose ulcers. , ... at Toledo, Ohio, are ecstatic that the procedure has succeeded very ...
... be round the corner as scientists have traced the pathway of ... with they have experimented on the rat brain and they are ... that such advances have been made vis-à-vis eating disorders. ... brain cells respond to hormones, among them two proteins called leptin ...
... scientists have created mice with unusually long memories raising hopes ... of helping people forget their distressing past. “This study has ... govern memory and learning in the brain,” said Isabelle Mansuy, ... , This breakthrough provides ...
... A herpes virus that causes infectious mononucleosis, Epstein-Barr virus (EBV), ... Hodgkin's disease. But no one has carefully studied the possible ... by Dr. Christina A. Clarke from Northern California Cancer Center ... This virus is believed to increase the risk for ...
... and wound healing has always been difficult terrain for scientists ... and understanding inter cellular mechanisms is the key to knowing ... Researchers led by Vito Quaranta at The ... protein that helps trigger the healing process -- also tells ...
Cached Medicine News:Health News:Scientists use plastic to help body make new bone!!!! 2
(Date:10/25/2014)... DUBLIN , October 24, 2014 ... has announced the addition of the "Global ... report to their offering.      (Logo: ... Concentrates Industry Report 2014 is a professional and ... hemodialysis concentrates industry with a focus on the ...
(Date:10/25/2014)... HOUSTON , Oct. 24, 2014   Metanome, ... of comprehensive metagenomic services and data analysis, was the ... Mass ) Phase I/II clinical trial of SER ... with recurrent Clostridium difficile infections (CDI). ... of Seres Health,s R&D and clinical programs. Such genomic ...
(Date:10/25/2014)... 2014 Burzynski Research Institute, Inc. (BRI) announced ... has given the company permission to conduct an open-label ... 3 months of age with a diffuse intrinsic brainstem ... of five treatment groups based on their age and ... DIPG. The primary study endpoint is a decrease in ...
Breaking Medicine Technology:Global and Chinese Hemodialysis Concentrates Industry Report 2014 2Global and Chinese Hemodialysis Concentrates Industry Report 2014 3Metanome Selected as Metagenomics Provider for Seres Health Clinical Trial 2Burzynski Research Institute, Inc. Announces FDA Permission to Launch a New Clinical Trial in Diffuse Intrinsic Brainstem Glioma 2
... , MORRISTOWN, N.J. , May 7 Watson Pharmaceuticals, ... Laboratories, Inc. has reached a settlement with Teva Women ,s Health, ... estradiol tablets USP, 0.15 mg/0.03 mg) product. , ... On December 13, 2007 , Teva filed a ...
... , May 7 Patients treated ... clinical improvement at two years, according to interim ... today as a late-breaking clinical trial at the ... Annual Scientific Sessions. The prospective, single-arm study is ...
Cached Medicine Technology:Watson Reaches Settlement with Teva Over Seasonale(R) 2Drug-Eluting Peripheral Stent Continues to Show Positive Data at Two Years 2Drug-Eluting Peripheral Stent Continues to Show Positive Data at Two Years 3
BatCup cotyloid implant, designed for use in revision surgery, is an hemispherical metal cup, with grooves on the edges that house locking flanges, which are attached to the iliac bone by cancellous ...
... Metal material and modularity into ... a fusion of technology and versatility ... for initial and long-term stability, but ... shell and liner options to address ...
The cementless biomEx cup can be used with both cemented and cementless femoral stems....
The Trilogy system builds on the success of the Harris/Galante Porous and HGP II cups by combining proven features with new technology designed to inhibit the formation and migration of polyethylene ...
Medicine Products: