Navigation Links
Genome of Leukemia Patient Reveals Common Mutations
Date:8/5/2009

Findings could help scientists understand genetic basis of cancer

WEDNESDAY, Aug. 5 (HealthDay News) -- Decoding the genome of a man with acute myeloid leukemia (AML) revealed genetic mutations that may be common among other cancer patients.

Scientists at the Washington University School of Medicine in St. Louis detected one mutation that's common in brain tumors called gliomas and another that was found in a second patient with AML.

Neither of the mutations had been previously linked to leukemia. The fact that these mutations sometimes occur in other patients suggest they play a role in the development and progression of cancer, they said.

The researchers sequenced the genome of a man who was diagnosed with AML at age 38 and had been in remission for more than three years. He was selected for genome sequencing because he had typical clinical and molecular features of the disease, including two AML-related mutations already known to the researchers.

They were surprised to find that 52 of the 64 mutations believed to be linked to the man's cancer were in long stretches of DNA between genes in regions of the genome that may influence how genes work, the researchers said. These areas of the genome are only now being studied for their possible connections with cancer.

"Other than the two mutations the patient was known to have before his genome was sequenced, we never would have guessed any of these mutations -- they were a huge surprise," study co-author Richard K. Wilson, director of the university's Genome Center, said in a school news release.

The study appeared online Aug. 5 in the New England Journal of Medicine.

While this new information doesn't yet point to new treatment options, it does show the strong potential of sequencing many cancer genomes to better understand the genetic basis of cancer.

"Only by sequencing complete genomes of cancer patients are we going to find unexpected, recurring genetic mutations that are highly likely to be important for cancer to develop and grow," study senior author Dr. Timothy Ley, a professor of medicine, said in the news release. "Gaining a genome-wide understanding of cancer lays the foundation for developing more powerful ways to diagnose, classify and treat patients."

More information

The U.S. National Cancer Institute has more about cancer genetics.



-- Robert Preidt



SOURCE: Washington University School of Medicine, news release, Aug. 5, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. One Species Genome Found Within Another
2. Genome Area Linked to Rheumatoid Arthritis
3. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
4. Scientists Map Elephantiasis Parasites Genome
5. Scientists Map Intestinal Bugs Genome
6. Hopkins researchers release genome data on autism
7. Baylor College of Medicine increases fleet of Roche Genome Sequencer FLX Systems to 10 instruments
8. Cats Genome Map Purrfected
9. Domestic cat genome sequenced
10. Guardian of genome predicts treatment outcomes for childhood cancer
11. Photo: Scientists Complete Genome Sequence of Fungus Responsible for Dandruff, Skin Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genome of Leukemia Patient Reveals Common Mutations 
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Planet Fitness, ... the U.S., announced today its plans to open a flagship location in Covington, LA ... the former Rooms To Go store next to Office Depot in the Holiday Square ...
(Date:10/12/2017)... ... 12, 2017 , ... Asante, a nationally recognized health system ... their existing home health joint venture through an agreement, effective October 1, 2017, ... venture home health company with Asante, delivering clinically integrated care, for the past ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... for the 49th Congress of the International Society of Paediatric Oncology (SIOP) ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)...   Divoti USA will engrave and process ... of the latest FDA requirements, which stipulates new criteria regarding medical ... need of Medical ID jewelry such as Medical ID Bracelets, can ... in terms of the new FDA requirements . ... Divoti offers this dark mark fiber laser ...
(Date:10/11/2017)... 2017  BioPharmX Corporation (NYSE MKT: BPMX) researchers were ... innovative way to use nonlinear optical imaging to confirm ... drugs. A ... show how researchers from BioPharmX and the Wellman Center ... a suite of imaging techniques in what is called ...
(Date:10/11/2017)... , Oct. 11, 2017  True Health, a ... amplified its effort during National Breast Cancer Awareness ... cancer risks. ... Oncology calculated that more than 10 million American ... mutations in BRCA1 or BRCA2 and have not had ...
Breaking Medicine Technology: