Navigation Links
Genome of Leukemia Patient Reveals Common Mutations
Date:8/5/2009

Findings could help scientists understand genetic basis of cancer

WEDNESDAY, Aug. 5 (HealthDay News) -- Decoding the genome of a man with acute myeloid leukemia (AML) revealed genetic mutations that may be common among other cancer patients.

Scientists at the Washington University School of Medicine in St. Louis detected one mutation that's common in brain tumors called gliomas and another that was found in a second patient with AML.

Neither of the mutations had been previously linked to leukemia. The fact that these mutations sometimes occur in other patients suggest they play a role in the development and progression of cancer, they said.

The researchers sequenced the genome of a man who was diagnosed with AML at age 38 and had been in remission for more than three years. He was selected for genome sequencing because he had typical clinical and molecular features of the disease, including two AML-related mutations already known to the researchers.

They were surprised to find that 52 of the 64 mutations believed to be linked to the man's cancer were in long stretches of DNA between genes in regions of the genome that may influence how genes work, the researchers said. These areas of the genome are only now being studied for their possible connections with cancer.

"Other than the two mutations the patient was known to have before his genome was sequenced, we never would have guessed any of these mutations -- they were a huge surprise," study co-author Richard K. Wilson, director of the university's Genome Center, said in a school news release.

The study appeared online Aug. 5 in the New England Journal of Medicine.

While this new information doesn't yet point to new treatment options, it does show the strong potential of sequencing many cancer genomes to better understand the genetic basis of cancer.

"Only by sequencing complete genomes of cancer patients are we going to find unexpected, recurring genetic mutations that are highly likely to be important for cancer to develop and grow," study senior author Dr. Timothy Ley, a professor of medicine, said in the news release. "Gaining a genome-wide understanding of cancer lays the foundation for developing more powerful ways to diagnose, classify and treat patients."

More information

The U.S. National Cancer Institute has more about cancer genetics.



-- Robert Preidt



SOURCE: Washington University School of Medicine, news release, Aug. 5, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. One Species Genome Found Within Another
2. Genome Area Linked to Rheumatoid Arthritis
3. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
4. Scientists Map Elephantiasis Parasites Genome
5. Scientists Map Intestinal Bugs Genome
6. Hopkins researchers release genome data on autism
7. Baylor College of Medicine increases fleet of Roche Genome Sequencer FLX Systems to 10 instruments
8. Cats Genome Map Purrfected
9. Domestic cat genome sequenced
10. Guardian of genome predicts treatment outcomes for childhood cancer
11. Photo: Scientists Complete Genome Sequence of Fungus Responsible for Dandruff, Skin Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genome of Leukemia Patient Reveals Common Mutations 
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
(Date:6/24/2016)... ... 2016 , ... People across the U.S. are sharpening their pencils and honing ... contest in which patients and their families pay tribute to a genetic counselor by ... Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In ...
(Date:6/24/2016)... Nevada (PRWEB) , ... June 24, 2016 , ... ... Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations ... in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a ...
(Date:6/24/2016)... ... 24, 2016 , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. ... service members that have been wounded in battle and their families. Venture Construction Group ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
Breaking Medicine Technology: