Navigation Links
Genome of Cancer-Free Rodent May Give Clues to Human Aging, Disease
Date:10/12/2011

By Amanda Gardner
HealthDay Reporter

WEDNESDAY, Oct. 12 (HealthDay News) -- Scientists announced Wednesday that they have succeeded in sequencing the full genome of the naked mole rat, an exceptionally long-lived and cancer-resistant rodent.

While that might not sound like headline news, scientists say the findings could provide insights into human aging and risks for malignancy.

"If we can understand the genetic adaptations, we may be able to find treatments which can change the human into a more long-lived species," said Vadim N. Gladyshev, senior author of the study published online Oct. 12 in the journal Nature.

Another expert, Dr. Greg Enders, associate professor of medicine at Fox Chase Cancer Center in Philadelphia, expressed enthusiasm. "This paper is an interesting piece of work [and may provide] useful hypotheses into how they can have such longevity and not cancer."

However, these ideas are still "all hypothetical in the future and very controversial," added Gladyshev, director of the Center for Redox Medicine at Brigham and Women's Hospital and Harvard Medical School in Boston.

On average, the naked (meaning hairless) mole rat lives more than 30 years, or almost 10 times as long as a typical mouse. Not only are they healthier for a longer period of time than other rodents, they live underground in the dark, are cold-blooded and can reproduce until they die. They do have poor vision, however.

"They have many unusual traits, and all of them are important in some way," said Gladyshev. "They are long-lived, live in low-oxygen conditions, are resistant to cancer, [and] don't maintain a stable body temperature."

In analyzing the genome of this remarkable mammal, the researchers noted some similarities with other mammals. The number of genes is about the same in naked mole rats (22,561), humans (22,389), mice (23,317) and rats (22,841).

Many of the naked mole rat genes are also located in the same place on the chromosome as human, mice and rat genes, the research revealed.

But in the naked mole rat, unlike in humans, there were few differences in how the genes were expressed at age 4 and at age 20.

There were eight cancer-related genes, one of which was the protein P16. "This is one of the major human tumor suppressor proteins, and it's clear that the naked mole rat has that protein and upregulates it more rapidly in certain situations that probably prevent cancer formation," Enders said.

The naked mole rat also produces less insulin than humans, has adapted its circulatory system and metabolism to deal with a low-oxygen environment and has few of the receptors that detect bitter tastes. These adaptations may eventually yield clues about living in extreme conditions, the researchers noted.

This research is just a start, Gladyshev said. "We and others probably will now carry out experimental studies on some of these findings to really understand in detail what this data means."

More information

Learn more about human genes at the Human Genome Project.

SOURCES: Vadim N. Gladyshev, Ph.D., director, Center for Redox Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston; Greg Enders, M.D., Ph.D., associate professor of medicine, Fox Chase Cancer Center, Philadelphia; Oct. 12, 2011, Nature, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. GenomeQuest Hosts Seminar Focused On Web-based Searching for Patent Information Across Global Sequence Databases
3. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
4. Mayo oral cancer study shows full tumor genome
5. Entire Family Genome Sequenced for First Time
6. Medicines Future Could Lie in Each Patients Genome
7. Human Genome Turns 10
8. Genome Sequencing Reveals How Breast Cancer Spreads
9. Patients whole genome reveals risk of diseases and adverse drug responses
10. Genome Scan Gives Man Insight Into Future Health Risks
11. Genome breakthrough allows scientists to identify and profile tumor cells from very small samples
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genome of Cancer-Free Rodent  May Give Clues to Human Aging, Disease
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Each year, ... will be held in Anaheim, CA at the Anaheim Convention Center. Almost 10,000 physical ... see new therapy products in action, learn more about their chosen field and network ...
(Date:2/12/2016)... CA (PRWEB) , ... February 12, 2016 , ... As ... a hectic schedule, a demanding job, and no time to decompress, Rabinowitz found herself ... dedicated herself to meditation for its impact on her life, implementing a 20-minute-per-day meditation ...
(Date:2/12/2016)... ... February 12, 2016 , ... Coco Libre, the maker of coconut ... Events LA GRAMMY’s Style Lounge Event. Coco Libre will offer musicians and celebrities the ... the big event. The invitation-only gifting suite, held this year at the W Hollywood ...
(Date:2/12/2016)... ... February 12, 2016 , ... T.E.N., a technology and ... the ISE Southeast Awards 2016. Finalists and winners of the ISE® Awards for ... Forum and Awards Gala on March 15, 2016 at the Westin Peachtree Plaza, ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... Series at Zuckerberg San Francisco General Hospital on April 5-7. The series is ... and create new habits. The workshops cover a broad range of topics, including ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , February 12, 2016 ... anders vermerkt)   http://www.sedar.com ) ... http://www.telestatherapeutics.com abrufbar.    --> ... Unternehmens http://www.telestatherapeutics.com abrufbar.    ... PNK:BNHLF) veröffentlichte heute seinen Konzernabschluss des zweiten ...
(Date:2/12/2016)... Feb. 12, 2016  Sequent Medical, Inc. announced today ... to evaluate the safety and effectiveness of the WEB™ ... ruptured intracranial aneurysms.  Prof Laurent Spelle , MD, ... Paris, France and Principal Investigator of ... France and Germany.  Although patients with ...
(Date:2/12/2016)... -- OMS Supply, a large provider of oral surgery supplies ... recent launching of their new company website. The OMS ... enhance the user experience and enable practitioners to browse ... --> --> Despite the fact that ... in early 2016, they have already made an unprecedented ...
Breaking Medicine Technology: