Navigation Links
Genome analysis of brain tumors showing the way to new treatment strategies
Date:7/26/2012

Brain tumors are the primary cause of cancer mortality in children. Even if a cure is possible, young patients often suffer from the stressful treatment which can be harmful to the developing brain. The most common childhood brain tumors are medulloblastoma and pylocytic astrocytoma.

In order to find new target structures for more gentle treatment methods, cancer researchers are systematically analyzing all changes in the genetic material of such tumors. This is the mission of the PedBrain consortium, which was launched in 2010 as the first German part in the International Cancer Genome Consortium (ICGC). The PedBrain Tumor network, which is coordinated by Professor Peter Lichter of DKFZ and Professor Roland Eils (DKFZ and Heidelberg University), has now published, jointly with numerous collaboration partners, an evaluation of the first 125 genome analyses of medulloblastomas.

"We can already see great differences in the genomes of medulloblastomas from one patient to the next," says Peter Lichter. "But we have also identified a number of frequent and characteristic genomic alterations that may lead the way to developing new methods of diagnosis and treatment."

Brain tumors with four sets of chromosomes are particularly aggressive

A high percentage of medulloblastomas particularly among those with very malignant progression has four sets of chromosomes instead of two as normal. Medulloblastomas are classified into four groups according to aggressiveness. In the study, about half of tumors belonging to groups 3 and 4, which are very difficult to treat, were found to have this aberration. "It is not proven that the extra chromosomes cause cancer. But it is certain that they occur at a very early stage of the cancerous process," Lichter explains.

Cells with four sets of chromosomes have been found in several types of cancer. However, this genomic aberration also offers a chance of specifically attacking tu
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mayo Clinic launches whole genome breast cancer study
2. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
3. Control of gene expression: Histone occupancy in your genome
4. Scientists Map Melanomas Genome
5. Genomes show how Staph bacteria gain resistance to last-line drug
6. Scientists Map the Tomatos Genome
7. Entire Genome of Human Fetus Deciphered
8. Bonobo Genome Sheds Light on Their Links to Chimps, Humans
9. Bioinformatics experts at the CNIO explore additional coding potential hidden in the human genome
10. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
11. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... Top10BestSEOHosting.com has recently announced that ... recommended suppliers for the webmasters who want to ... According to the senior spokesman for Top10BestSEOHosting.com, these ... hosting products on the market and specializes in ... of online deals when service plans are purchased ...
(Date:8/19/2014)... has recently compared many popular hosting suppliers and announced ... recommended companies for webmasters who want to buy high ... an affordable price. , Both GoDaddy and iPage ... the lowest upfront costs (including some Joomla hosting products ... of options. , GoDaddy is a famous supplier ...
(Date:8/19/2014)... News) -- Lupus and other rheumatic diseases can ... which can delay a correct diagnosis for months, ... diseases can also cause these types of symptoms, ... in Maywood, Ill. Rheumatic disorders include autoimmune ... tissues, such as lupus, systemic vasculitis and ankylosing ...
(Date:8/19/2014)... ME (PRWEB) August 19, 2014 Drews Dental ... J. Drews, D.D.S., to vice president of the Maine Dental ... MDA for three years, Dr. Drews has now been sworn ... forward to serving his term as vice president and being ... as well as the First District Caucus in 2015. He ...
(Date:8/19/2014)... August 19, 2014 Following the completion of ... Hyatt Tampa Bay is proud to debut the highly ... project included a full revamp of all public spaces to ... rooms and suites, an all-new dining experience at 1823 Kitchen ... lobby. , With the introduction of 1823 Kitchen and Bar, ...
Breaking Medicine News(10 mins):Health News:Fatcow Awarded As One of the Best Web Hosting Suppliers at Top10bestseohosting.com 2Health News:Top10BestSEOHosting.com: Cheap Joomla Hosting Reviews Unveiled 2Health News:Certain Symptoms Can Delay Lupus Diagnosis, Researchers Report 2Health News:Dr. Drews Elected VP of Maine Dental Association 2Health News:Grand Hyatt Tampa Bay Hotel Unveils the Finishing Touches of Its $20 Million Makeover 2
... Hosts First Annual Exclusive Wine ... Gala, WASHINGTON, Dec. 14 Starlight Starbright,Children,s ... Annual Exclusive Wine Dinner and Eighth Annual Taste ... events were hosted at the,award-winning Michel Richard Citronelle ...
... Provides Reliable, Quick Patient-Information Retrieval From ... JOLIET, Ill., Dec. 14 AT&T Inc. ... Oncology-Hematology Associates, Ltd. (JOHA) has,awarded AT&T a ... in addition to other network solutions. Continuing ...
... 14 Barr Pharmaceuticals,Inc. (NYSE: BRL ) ... has filed suits against Watson Pharmaceuticals (NYSE:,WPI) and ... NVS ) for,infringement of the patent protecting Duramed,s ... litigation in the,U.S. District Court for the District ...
... Classification for Innovative New Treatments, AMSTERDAM, December ... product ATIR has received approval for regulatory,classification as ... Task,Force (ITF), a division of the European Medicines ... eligible for EMEA procedures. As a,next step Kiadis ...
... crowded roadways face more than 50% risk of breathing trouble, ... with asthma who are exposed to traffic pollution are at ... a study that looked at children in the Mexican border ... States. , "Major cities along the northern and southern ...
... LTC Financial Partners Offers Newsletter & Online Help for Living Longer, ... ... their,life spans, many eyeing 100-plus, the odds of needing long term care,increase. One ... says Cameron Truesdell, CEO of LTC Financial Partners,(LTCFP), "is the insurance plus health ...
Cached Medicine News:Health News:Premier Children's Charity Sets Fundraising Record With Back-to-Back Events 2Health News:Premier Children's Charity Sets Fundraising Record With Back-to-Back Events 3Health News:Premier Children's Charity Sets Fundraising Record With Back-to-Back Events 4Health News:Local Joliet Physician Group Selects AT&T for Managed Online Data Solutions 2Health News:Local Joliet Physician Group Selects AT&T for Managed Online Data Solutions 3Health News:Barr Subsidiary Sues Watson and Sandoz for SEASONALE(R) Patent Infringement 2Health News:Barr Subsidiary Sues Watson and Sandoz for SEASONALE(R) Patent Infringement 3Health News:Barr Subsidiary Sues Watson and Sandoz for SEASONALE(R) Patent Infringement 4Health News:ATIR Classified as "Cell Based" Medicinal Product by the EMEA 2Health News: Traffic Pollution Hurts Asthmatic Kids' Lungs 2Health News:As More Americans Live to 100, Long Term Care Insurance Leader Gives Health Assist 2
(Date:8/19/2014)... DUBLIN , Aug. 19, 2014 ... the "Pharmaceutical Contract Manufacturing - Global Strategic Business ... This report analyzes the worldwide markets for Pharmaceutical Contract ... Injectables (Injections, Vials, and IV solutions), Solid Dosage Forms ... (Syrups, Suspensions, Gels, Creams & Ointments). The ...
(Date:8/19/2014)... , Aug. 19, 2014 Research and Markets ... by Type of Material, by Technology, by Application & by ... their offering. The demand for membranes is ... driving the market to $29.31 billion Membrane technology ... applications, such as water filtration and kidney dialysis. In modern ...
(Date:8/19/2014)... According to Kalorama Information, electronic medical records ... Data in healthcare a reality, and this a factor ... American Recovery and Reinvestment Act, the U.S. government dedicated ... penalties will start applying soon for use of paper ... study of the EMR industry, EMR 2014: The ...
Breaking Medicine Technology:Global Pharmaceutical Contract Manufacturing - Strategic Business Report 2014 2Global Membranes (MF, RO, UF, Gas Separation, Dialysis, NF) Market - Forecasts to 2019 2Kalorama: EMR Paves the Way for Big Data 2Kalorama: EMR Paves the Way for Big Data 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: