Navigation Links
Genome Study Points to New Culprit for Schizophrenia

Findings show most previous work missed key DNA variant, researchers say

FRIDAY, Feb. 6 (HealthDay News) -- Large, rare structural changes in DNA called copy number variants may play a role in schizophrenia, according to U.S. researchers, who said their findings support a sharp change of direction in genetics research on schizophrenia.

Over the past two decades, researchers have identified dozens of genes and single nucleotide polymorphisms (SNPs or "snips") that could be linked to schizophrenia. But this new study dismisses all of them.

"The literature is replete with dozens of genes and SNPs identified as associated with schizophrenia. But we systematically retested all the leading candidates and concluded that most, if not all of them, are false positives," study lead author Anna Need, a postdoctoral associate at the Center for Human Genome Variation at the Duke Institute for Genome Sciences & Policy, said in a Duke University news release.

Most of the previous studies were too small to properly assess the role of SNPs in schizophrenia, Need said.

She and her colleagues analyzed the genomes of schizophrenia patients and healthy people for SNPs and copy number variants (CNVs). None of the previously identified SNPs appeared significant in schizophrenia, but the researchers identified several CNVs they believe may be associated with the psychiatric disorder.

CNVs are common and usually appear as deletions or duplications of significant stretches of DNA. But the largest deletions -- those over 2 million bases long -- appear only in people with schizophrenia, Need said.

The study was published Feb. 6 in the journal PLoS Genetics.

"What this means is that if we are going to make real headway in assessing genetic links to schizophrenia, we will have to sequence the entire genome of each schizophrenia patient," Need said. "That is a tremendous amount of work, but it is the only way we will be able to find these extremely rare variations."

More information

Mental Health America has more about schizophrenia.

-- Robert Preidt

SOURCE: Duke University, news release, Feb. 5, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. One Species Genome Found Within Another
2. Genome Area Linked to Rheumatoid Arthritis
3. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
4. Scientists Map Elephantiasis Parasites Genome
5. Scientists Map Intestinal Bugs Genome
6. Hopkins researchers release genome data on autism
7. Baylor College of Medicine increases fleet of Roche Genome Sequencer FLX Systems to 10 instruments
8. Cats Genome Map Purrfected
9. Domestic cat genome sequenced
10. Guardian of genome predicts treatment outcomes for childhood cancer
11. Photo: Scientists Complete Genome Sequence of Fungus Responsible for Dandruff, Skin Disorders
Post Your Comments:
Related Image:
Genome Study Points to New  Culprit for Schizophrenia
(Date:11/27/2015)... County, CA (PRWEB) , ... November 27, 2015 , ... ... season , The company is offering customers 10% off of their purchase of lice ... any treatment at full price. According to a company spokesperson. “Finding lice is a ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion is ... Pro X. With ProSidebar: Fasion, video editors can easily add an informative sidebar ... minimalist title opener. Utilize presets featuring self-animating drop zones, lines, bars, and text ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... through sharing, the 2016 Building Better Radiology Marketing Programs meeting will ... on Sunday, March 6, 2016, at Caesars Palace in Las Vegas with a ...
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, "Voices ... show that delves into an array of issues that are presently affecting Americans. Dedicated ... open dialogue, this show is changing the subjects consumers focus on, one episode at ...
(Date:11/27/2015)... ... 27, 2015 , ... Keeping in mind challenges faced by ... wellness consultation, has collaborated with a leading web-based marketplace for extra-curricular activities for ... parents and bring advice from parenting experts within their reach. As a part ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... ) ... "Global Brain Monitoring Devices Market 2015-2019" ... ) has announced the addition of ... 2015-2019" report to their offering. ... ) has announced the addition of the ...
(Date:11/25/2015)...  Linden Care, LLC, a retail specialty pharmacy focused ... suffering from chronic pain, said today that it is ... (TRO) enjoining Express Scripts from unilaterally terminating the Pharmacy ... --> --> The company said that ... --> --> In ...
(Date:11/25/2015)...  Henry Schein, Inc., the world,s largest provider of ... and animal health practitioners, will unveil at the Greater ... ConnectDental® Pavilion , which brings together for the first ... to help any practice or laboratory enter the digital ... schedule of experts appearing at the Pavilion. --> ...
Breaking Medicine Technology: