Navigation Links
Genome Study Points to New Culprit for Schizophrenia
Date:2/6/2009

Findings show most previous work missed key DNA variant, researchers say

FRIDAY, Feb. 6 (HealthDay News) -- Large, rare structural changes in DNA called copy number variants may play a role in schizophrenia, according to U.S. researchers, who said their findings support a sharp change of direction in genetics research on schizophrenia.

Over the past two decades, researchers have identified dozens of genes and single nucleotide polymorphisms (SNPs or "snips") that could be linked to schizophrenia. But this new study dismisses all of them.

"The literature is replete with dozens of genes and SNPs identified as associated with schizophrenia. But we systematically retested all the leading candidates and concluded that most, if not all of them, are false positives," study lead author Anna Need, a postdoctoral associate at the Center for Human Genome Variation at the Duke Institute for Genome Sciences & Policy, said in a Duke University news release.

Most of the previous studies were too small to properly assess the role of SNPs in schizophrenia, Need said.

She and her colleagues analyzed the genomes of schizophrenia patients and healthy people for SNPs and copy number variants (CNVs). None of the previously identified SNPs appeared significant in schizophrenia, but the researchers identified several CNVs they believe may be associated with the psychiatric disorder.

CNVs are common and usually appear as deletions or duplications of significant stretches of DNA. But the largest deletions -- those over 2 million bases long -- appear only in people with schizophrenia, Need said.

The study was published Feb. 6 in the journal PLoS Genetics.

"What this means is that if we are going to make real headway in assessing genetic links to schizophrenia, we will have to sequence the entire genome of each schizophrenia patient," Need said. "That is a tremendous amount of work, but it is the only way we will be able to find these extremely rare variations."

More information

Mental Health America has more about schizophrenia.



-- Robert Preidt



SOURCE: Duke University, news release, Feb. 5, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. One Species Genome Found Within Another
2. Genome Area Linked to Rheumatoid Arthritis
3. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
4. Scientists Map Elephantiasis Parasites Genome
5. Scientists Map Intestinal Bugs Genome
6. Hopkins researchers release genome data on autism
7. Baylor College of Medicine increases fleet of Roche Genome Sequencer FLX Systems to 10 instruments
8. Cats Genome Map Purrfected
9. Domestic cat genome sequenced
10. Guardian of genome predicts treatment outcomes for childhood cancer
11. Photo: Scientists Complete Genome Sequence of Fungus Responsible for Dandruff, Skin Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genome Study Points to New  Culprit for Schizophrenia
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating ... Millions of individuals in the United States and Canada wear eyeglasses. Once considered to ... correct vision and make a fashion statement. Even celebrities use glasses as a way ...
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered ... Latin America . ... ... ... ...
Breaking Medicine Technology: