Navigation Links
Genome Sequencing Reveals How Breast Cancer Spreads
Date:4/14/2010

Findings could lead to development of more targeted treatments, researcher says,,

WEDNESDAY, April 14 (HealthDay News) -- Genetic analysis of a woman with breast cancer has yielded important information about an extremely dangerous type of breast cancer that largely affects blacks and younger women, say U.S. researchers.

By comparing three genomes -- the genome of a 44-year-old black woman who had "triple negative" breast cancer and the genomes of her breast tumor and a metastatic tumor that developed in her brain -- the scientists identified 20 genetic changes in a subset of breast tumor cells that probably played a role in the spread of the cancer that led to her death within a few months.

The findings suggest that sequencing entire genomes of cancer patients, along with the genomes of their primary and metastatic tumors, could improve understanding of how tumors spread and possibly lead to the development of new drugs that target important cancer-causing genetic errors, according to the researchers, from the Washington University School of Medicine in St. Louis.

"We are getting an intimate look at the lethal spread of a breast cancer, which is now possible because we can sequence entire genomes quickly at reasonable cost," Elaine Mardis, co-director of the university's Genome Center and the study's senior author, said in a university news release.

"This work lays the foundation for understanding the genetic basis of tumor progression and metastasis and for identifying new drug targets that can improve the outlook for women with this disease," she added.

The study is published in the April 15 issue of Nature.

More information

The U.S. National Cancer Institute has more about breast cancer.



-- Robert Preidt



SOURCE: Washington University School of Medicine in St. Louis, news release, April 14, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Human Genome Turns 10
2. Medicines Future Could Lie in Each Patients Genome
3. Entire Family Genome Sequenced for First Time
4. Mayo oral cancer study shows full tumor genome
5. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
6. GenomeQuest Hosts Seminar Focused On Web-based Searching for Patent Information Across Global Sequence Databases
7. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
8. Genome Mapped for Type 2 Diabetes
9. Scientists map out regulatory regions of genome, hot spots for diabetes genes
10. Researchers fight world hunger by mapping the soybean genome
11. Research Reveals How Breast Cancer Rearranges Genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine ... Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
(Date:6/23/2016)... Pa. , June 23, 2016 Bracket ... will launch its next generation clinical outcomes platform, Bracket eCOA ... Meeting held on June 26 – 30, 2016 in ... the first electronic Clinical Outcome Assessment product of its kind ... Booth #715. Bracket eCOA 6.0 is a flexible ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at www.diabetesscholars.org by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
Breaking Medicine Technology: