Navigation Links
Genome Research publishes special issue: Cancer Genomics
Date:2/1/2012

1/gr.118919.110

4. Cutting-edge methods to detect the genes and networks that drive cancer

The special Cancer Genomics issue of Genome Research also features cutting-edge methodological advances, including three reports that address the problem of identifying the genes, networks, and pathways that drive cancer.

A significant challenge to the identification of genetic alterations that lead to cancer is the experimental determination of which mutations are driving cancer and which mutations are random "passengers." Further complicating discovery of drivers is that driver mutations can target multiple cellular pathways and processes, and each cancer can present different mutations that are sufficient to disrupt critical pathways.

Two reports in this issue present new computational strategies to finding biological pathways that are commonly disrupted by diverse genomic alterations. Vandin and colleagues developed a pair of computational strategies collectively called Dendrix to spot groups of genes that constitute "driver pathways." Applying Dendrix to three cancer studies, Vandin et al. successfully identify sets of genes that are mutated in large numbers of patients, including well-known cancer-related pathways such as Rb, p53, mTOR, and MAPK.

Ciriello and colleagues have developed the Mutual Exclusivity Modules in Cancer (MEMo) method to identify previously unrecognized oncogenic pathways. Applying MEMo to datasets of genomic alterations in glioblastoma and ovarian cancer, MEMo successfully identified known oncogenic pathways and presented evidence for a new hypothesis for the striking genomic instability of ovarian tumors. Dendrix and MEMo will be particularly useful for the interpretation of very large cancer genome sequencing studies, many currently underway.

Also in this issue, Xiong et al. present Gene Set Association Analysis (GSAA), a statistical framework that integrates and simul
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. GenomeQuest Hosts Seminar Focused On Web-based Searching for Patent Information Across Global Sequence Databases
3. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
4. Mayo oral cancer study shows full tumor genome
5. Entire Family Genome Sequenced for First Time
6. Medicines Future Could Lie in Each Patients Genome
7. Human Genome Turns 10
8. Genome Sequencing Reveals How Breast Cancer Spreads
9. Patients whole genome reveals risk of diseases and adverse drug responses
10. Genome Scan Gives Man Insight Into Future Health Risks
11. Genome breakthrough allows scientists to identify and profile tumor cells from very small samples
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Seeking to make it tougher for people to misuse ... Thursday approved a new hydrocodone tablet that,s designed to ... the brand name Vicodin -- is a powerful opioid ... dangerous addictions across the United States. The FDA ... an extended-release tablet to treat pain severe enough to ...
(Date:11/21/2014)... November 21, 2014 MLF Biotech, Inc. ... cats . Liv-Pro® Probiotics for Pets helps maintain digestive ... to a pet's intestinal flora after it experiences a ... , Liv-Pro Probiotics for Pets is a proprietary blend ... contains seven live active bacteria strains that are safe ...
(Date:11/21/2014)... NJ (PRWEB) November 21, 2014 The ... homemade, high calorie dishes, plenty of gravy and a ... could be the best time of year to begin ... Diet Doc has uncovered the secret to losing unhealthy, ... the fattening holiday recipes. , The insight to Diet ...
(Date:11/21/2014)... Lauderdale, Florida (PRWEB) November 21, 2014 ... for chronic headaches and other jaw-related symptoms, ... patients seeking relief from chronic head pain, neck pain, ... , “This year we have seen a 52% ... treated. Our network of over 300 doctors and their ...
(Date:11/21/2014)... Even with years of experience under his belt, Kirk ... growth, participating in two recent events for his State Farm ... networking event with the leaders of State Farm and thousands ... and greatest in insurance news and products for his clients. ... (Stacy, Anthony, Reina and Jacob) as exhibitors at the recent ...
Breaking Medicine News(10 mins):Health News:FDA Approves 'Abuse-Resistant' Narcotic Painkiller 2Health News:FDA Approves 'Abuse-Resistant' Narcotic Painkiller 3Health News:MLF Biotech Introduces Liv-Pro Probiotics for Pets 2Health News:Diet Doc Releases New Calorie Loading Diet Plans - the Perfect Way to Jump Start the Metabolism and Begin Weight Loss During Thanksgiving 2Health News:Diet Doc Releases New Calorie Loading Diet Plans - the Perfect Way to Jump Start the Metabolism and Begin Weight Loss During Thanksgiving 3Health News:Diet Doc Releases New Calorie Loading Diet Plans - the Perfect Way to Jump Start the Metabolism and Begin Weight Loss During Thanksgiving 4Health News:National Rise In Patients Seeking Headache Relief 2Health News:Kirk Martin Insurance Agency Goes Local and National with State Farm 2
... stroke patients have not had a great track record ... Zealand focused on Maori and Pacific populations shows how ... and families in charge can make a difference to ... in the journal Clinical Rehabilitation , which is ...
... , TUESDAY, Nov. 15 (HealthDay News) -- Dieters appear to ... weight-loss counseling, two different studies suggest. Even if that ... can translate to more weight loss, the experts found. Either ... studies will be presented this week at the American Heart ...
... Nov. 15 (HealthDay News) --,Pneumonia is the most common infection ... also revealed that most infections occur about two weeks after ... are slated to present their findings Tuesday at the American ... not what we expected to find," study author Dr. Michael ...
... screening may increase awareness of the dangers of smoking and ... November 2011 issue of Otolaryngology-Head and Neck Surgery . ... 80% of head and neck cancers could be curbed by ... to date have had little impact reducing these mortalities. ...
... Disease Control and Prevention (CDC) has awarded Mayo Clinic ... in Ethiopia. The five-year award will support Mayo Clinic ... develop online education courses that disseminate best practices and ... The HIV eCurriculum project will be led by ...
... process. An early sign that it has begun is high ... insulin-producing beta cells are able to compensate for the increased ... sugar levels remain normal. It is not until the capacity ... 2 diabetes becomes a fact. The latter stage generally goes ...
Cached Medicine News:Health News:Putting stroke patients in charge improves quality of life 2Health News:Putting stroke patients in charge improves quality of life 3Health News:Looking to Lose Weight? Get a 'Coach' 2Health News:Looking to Lose Weight? Get a 'Coach' 3Health News:Pneumonia Most Common Infection After Heart Surgery 2Health News:Population-specific community-based cancer screening may discourage smoking 2Health News:CDC and Prevention awards Mayo Clinic an international medical education grant 2Health News:Molecular link between diabetes and cancer described 2
(Date:11/21/2014)...  Abaxis, Inc. (NasdaqGS: ABAX ), a ... the medical, research, and veterinary markets worldwide and providing ... in the United States , announced ... acquire 100% of QCR & Trio Diagnostics Limited, a ... The transaction closed on November 17, 2014. ...
(Date:11/21/2014)... MELVILLE, N.Y. , Nov. 21, 2014 ... one of the world,s largest health care services companies, ... the world,s largest provider of health care products and ... today announced that the companies have entered into a ... comprehensive service and product offerings to office-based medical practices.  ...
(Date:11/21/2014)... BRYDGES, Ontario , Nov. 20, 2014 /PRNewswire/ ... monitor mounting solutions and reading room environment guidance, ... their newest musculoskeletal radiology reading room, which may ... room designs at Penn Medicine. ... by the American College of Radiology,s Imaging 3.0 ...
Breaking Medicine Technology:Abaxis Acquires UK-based Distribution Organization 2Abaxis Acquires UK-based Distribution Organization 3Abaxis Acquires UK-based Distribution Organization 4Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 2Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 3Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 4Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 5RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 2RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 3
... 2011 PDI, Inc. (Nasdaq: PDII ) ... DIAGRAM™ software platform to enable eDetail delivery on popular ... ® and iPhone ® (1) and Android™(2)-based phones. ... devices even faster than the general population, we are ...
... April 25, 2011 Pharmatek Laboratories, Inc., a ... pharmaceutical industry, announced that it has added spray ...  The company has purchased a Buchi B-290 Mini ... clinical manufacture.  This technology can be used for ...
Cached Medicine Technology:PDI Announces Group DCA's Launch of eDetailing Across Apple® and Android™ Mobile Devices 2Pharmatek Laboratories Adds Spray Drying to Drug Development Services 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: