Navigation Links
Genome Research publishes special issue: Cancer Genomics
Date:2/1/2012

1/gr.118919.110

4. Cutting-edge methods to detect the genes and networks that drive cancer

The special Cancer Genomics issue of Genome Research also features cutting-edge methodological advances, including three reports that address the problem of identifying the genes, networks, and pathways that drive cancer.

A significant challenge to the identification of genetic alterations that lead to cancer is the experimental determination of which mutations are driving cancer and which mutations are random "passengers." Further complicating discovery of drivers is that driver mutations can target multiple cellular pathways and processes, and each cancer can present different mutations that are sufficient to disrupt critical pathways.

Two reports in this issue present new computational strategies to finding biological pathways that are commonly disrupted by diverse genomic alterations. Vandin and colleagues developed a pair of computational strategies collectively called Dendrix to spot groups of genes that constitute "driver pathways." Applying Dendrix to three cancer studies, Vandin et al. successfully identify sets of genes that are mutated in large numbers of patients, including well-known cancer-related pathways such as Rb, p53, mTOR, and MAPK.

Ciriello and colleagues have developed the Mutual Exclusivity Modules in Cancer (MEMo) method to identify previously unrecognized oncogenic pathways. Applying MEMo to datasets of genomic alterations in glioblastoma and ovarian cancer, MEMo successfully identified known oncogenic pathways and presented evidence for a new hypothesis for the striking genomic instability of ovarian tumors. Dendrix and MEMo will be particularly useful for the interpretation of very large cancer genome sequencing studies, many currently underway.

Also in this issue, Xiong et al. present Gene Set Association Analysis (GSAA), a statistical framework that integrates and simul
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. GenomeQuest Hosts Seminar Focused On Web-based Searching for Patent Information Across Global Sequence Databases
3. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
4. Mayo oral cancer study shows full tumor genome
5. Entire Family Genome Sequenced for First Time
6. Medicines Future Could Lie in Each Patients Genome
7. Human Genome Turns 10
8. Genome Sequencing Reveals How Breast Cancer Spreads
9. Patients whole genome reveals risk of diseases and adverse drug responses
10. Genome Scan Gives Man Insight Into Future Health Risks
11. Genome breakthrough allows scientists to identify and profile tumor cells from very small samples
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... NJ (PRWEB) August 30, 2014 The ... facilities in New Jersey and even in the U.S. ... that takes inches off of patients’ waists with deep-tissue ... cells in small sections, Vanquish is more inclusive to ... Patients lay comfortably under panels about one inch ...
(Date:8/30/2014)... After offering hyperbaric oxygen therapy ... past several years, Dr. Roy Schmidt and the ... a scholarship program for veterans who have been ... held this summer to discuss veterans’ needs ( ... shed light on the large number of veterans ...
(Date:8/30/2014)... Beach, Calif. (PRWEB) August 30, 2014 Insomnia ... Francis helps listeners understand how they unknowingly developed insomnia and ... have restful nights during. Tune in to the show ... The show airs live on August 30, and will ... more information on programming, go to DrCarolFrancisTalkRadio.com. , ...
(Date:8/30/2014)... PA (PRWEB) August 30, 2014 "My ... result of a car accident," said one of two ... muscle strain in her shoulder and neck area. She ... invented reduced pain and pressure, assisting in comfort and ... the patent-pending PILLOW CRADLE to support the head, neck ...
(Date:8/30/2014)... Bringing forth the great opportunities, India's ... Labor Day discount on all SEO services. While working ... services related to internet marketing. Their dedicated team of ... do have a deep understanding for their specialization. This ... and since the inception, they have worked with over ...
Breaking Medicine News(10 mins):Health News:NJ Top Docs Presents, The Plastic Surgery Group 2Health News:Tennessee Hyperbaric Center Offering HBOT Scholarships to Veterans 2Health News:Sleepless Nights, Exhausting Days, Mental Fog – Relief for Insomnia With Clinical Psychologist Dr. Carol Francis 2Health News:Profit By Search Announces Labor Day Discount on SEO Services 2
... difficult for doctors to tell whether a patient with ... inflammation, which can be treated with medicine. A new ... a U-M-led study. Ultrasound elasticity imaging, or UEI, ... inflammation and fibrosis, allowing patients to receive more appropriate ...
... State University of New York has received two grants ... of Health (NIH) to support neuroscience and pediatric pharmacology ... collaborative research network of SUNY,s four academic health centers ... both grants will be headquartered at SUNY Downstate Medical ...
... who experience new onset breast tenderness after starting combination ... cancer compared to women who don,t experience breast tenderness, ... Center has shown. One reason for this may be ... new onset tenderness was much more pronounced after initiation ...
... more effective than the current standard treatment. This is ... treatments, described by Thilo Schwandner and colleagues in the ... Dtsch Arztebl Int 2011; 108[39]: 653-60). In ... The problem is often caused by weakness of the ...
... 1982, alone in a laboratory, chemist Dan Shechtman looked ... He had discovered quasicrystals. But his groundbreaking findings ... years. On October 5, 2011, Shechtman received ... to stand by his research? What drove the men ...
... News) -- Teen drivers are 50 percent more likely to crash ... are after driving for a full year, according to a study ... drivers are nearly twice as likely to crash in the first ... the study found. However, parents can help teens prevent accidents ...
Cached Medicine News:Health News:Imaging technology might help doctors determine best treatment for Crohn's disease patients 2Health News:SUNY receives $4.3 million for research in neuroscience, pediatric pharmacology and vision 2Health News:SUNY receives $4.3 million for research in neuroscience, pediatric pharmacology and vision 3Health News:Breast tenderness in women getting combo hormone therapy associated with increase in breast density 2Health News:Breast tenderness in women getting combo hormone therapy associated with increase in breast density 3Health News:How and why did 2011 Nobel winner Dan Shechtman persist despite rejection? 2Health News:Teen Crash Risk High in First Month of Driving, Study Finds 2
(Date:8/29/2014)... 29, 2014  Abaxis, Inc. (NasdaqGS: ABAX ... and consumables to the medical, research and veterinary markets, ... Chief Executive Officer, will present at the CL King ... Tuesday, September 9, 2014 at 12:30 p.m. ET. The ... Hotel in New York City . ...
(Date:8/29/2014)... 2014 Pixcelldata, the innovative Irish ... announced a major new deal with Dutch based eX-Path, ... expert, Dr. Marius Nap . The ... Congress of Pathology which is taking placing between August ... London where Pixcelldata will demonstrate its ...
(Date:8/29/2014)... Mass. , Aug. 29, ... PHG AEX: ... the  European Society of Cardiology ... is highlighting the full range of its cardiology solutions serving ... care continuum from prevention and diagnosis, ...
Breaking Medicine Technology:Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 2Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 3Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 4Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 5
... 2011 /PRNewswire-Asia-FirstCall/ -- American Oriental Bioengineering, Inc. (NYSE: ... Stock Exchange (the "NYSE") has notified the Company that the ... requires a minimum average closing price of $1.00 per share ... the Company has six months from receipt of the notice ...
... Business Journal recently announced that eCardio Diagnostics ( www.ecardio.com ) ... included a distinguished list of 100 of the fastest growing ... ranked No. 17 with a two-year growth of 146.37%. This ... prestigious award. "There were so many inspiring companies ...
Cached Medicine Technology:American Oriental Bioengineering Inc. Receives NYSE Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard 2eCardio Among Honorees of the Houston Business Journal's Fast 100 List for Second Consecutive Year 2