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Genome Research publishes special issue: Cancer Genomics
Date:2/1/2012

tal tumor genomes. The group identified four distinct DNA methylation subgroups of colorectal cancer, and provided new insight into the role of DNA hypermethylation in gene silencing critical for tumor suppression. The report by Xu and colleagues also delves into DNA hypermethylation in colorectal cancer, describing the mapping and comparison of DNA methylation profiles by genome sequencing. The group found that certain sites of the genome are prone to hypermethylation in colorectal cancer, with a certain class of tumors prone to even more extensive hypermethylation, suggesting specific defects in the control of this epigenetic modification.

Chemical modification of chromatin, the complex of DNA and protein that packages the genome within the nucleus, also plays a critical regulatory role in gene expression in healthy and disease states. In this issue, Valdes-Mora and colleagues have investigated the interplay between a specific chromatin modification, H2A.Z acetylation, and other epigenetic modifications including DNA methylation in prostate cancer. This work reconciles conflicting evidence in the field regarding the role of H2A.Z acetylation, and further shows for the first time that it is a critical modification associated with gene activity in normal cells, and epigenetic deregulation of genes in cancer.

References:

Hon et al., Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res. doi:10.1101/gr.125872.111

Hinoue et al., Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res. doi:10.1101/gr.117523.110

Xu et al., Unique DNA methylome profiles in CpG island methylator phenotype colon cancers. Genome Res. doi:10.1101/gr.122788.111

Valds-Mora et al., Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer. Genome Res. doi:10.110
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Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

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