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Genome Research publishes special issue: Cancer Genomics
Date:2/1/2012

Genome Research (www.genome.org) publishes online and in print today a special issue entitled, "Cancer Genomics," highlighting insights gained form cutting-edge genomic and epigenomic analyses of cancer.

Included in this special issue are novel biological insights gained from genomic analyses of pancreatic cancer, ovarian cancer, and melanoma, including, functional genomic analyses of breast cancer genes, large scale colorectal and breast cancer epigenomics, advances in methodology identifying driver genes and networks in cancer, in genome-wide cancer association analyses, and using next-generation sequencing technology to detect driver mutations. Additionally, the issue includes unique perspectives from leaders in the field on the translation of cancer genomics to improved outcomes in medicine. The following sections highlight several of the papers published in the issue.

1. Whole-genome and whole-exome sequencing: Searching for the drivers of cancer

Cancer is believed to arise through the accumulation of genetic and epigenetic mutations that give tumor cells an advantage over normal tissue, driving the proliferation and spread of disease. Next-generation sequencing technologies are ushering in a new era of discovery in cancer genomics, shedding light on the genomic alterations underlying various cancers. And as sensitive and high-resolution sequencing is rapidly becoming affordable, routine clinical sequencing of whole exomes and whole genomes of cancers is nearly within reach.

In a rare opportunity to sequence the genome of a primary and a corresponding metastatic melanoma in a patient who had not received prior treatment with therapeutic DNA-damaging agents, Turajilic and colleagues have characterized somatic mutations and genomic structural variation in a primary acral melanoma, a rare sub-type of cutaneous melanoma that can arise on the non-hairy skin of the palms of
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Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4 5 6 7

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