Navigation Links
Genomas Presents Drug-Specific Genetic Determinants of Statin Safety and Efficacy at the XV International Symposium on Atherosclerosis
Date:6/15/2009

Data Being Used to Develop DNA-Guided Decision Support for Statin Prescription

BOSTON, June 15 /PRNewswire/ -- Genomas, a biomedical company advancing DNA-guided medicine and personalized healthcare, announced its participation at the prestigious XV International Symposium on Atherosclerosis, a meeting held triennially by the International Atherosclerosis Society. Gualberto Ruano, MD, PhD, President of Genomas, will present "Physiogenomic Contours of Statin Safety and Efficacy," a clinical study examining the differences in response to statin drugs based on individual gene variations.

Statins offer effective strategies to reduce cardiovascular disease and improve survival. However, there are clinically relevant safety risks for some patients. Statin-induced neuro-myopathy (SINM) may present as muscle aches, cramps, weakness, and muscle injury. SINM is more frequent at the higher doses required for treating advanced heart disease, and varies in extent between individual statins and from patient to patient. In previously published studies, over 10% of statin patients experienced neuromuscular side effects, causing disruptions in daily life activities, and reduction in regimen adherence.

In this study, 442 outpatients treated with atorvastatin, rosuvastatin and/or simvastatin were studied in lipid clinics at Hartford Hospital (Hartford, CT) and the University of California, San Francisco. Researchers genotyped 384 SNPs (single nucleotide polymorphisms) from 222 cardiometabolic and neuroendocrine genes with a potential role in determining the safety and efficacy of statins. The study was funded in part by a grant from the National Institute of General Medical Sciences of the National Institutes of Health.

"Contrasting quantitatively how the gene polymorphisms associate with clinical responses, we visualize the 'physiogenomic contours' of statin drugs," said Dr. Ruano. "These contours represent the mechanistic differences among statins, which we plan to use as the foundation for DNA-guided rules for treatment on a patient-individualized basis."

ABOUT GENOMAS

Genomas is a biomedical company advancing DNA-guided medicine and personalized healthcare. The company is developing and testing revolutionary PhyzioType(TM) Systems for DNA-guided diagnosis and prevention of metabolic disorders induced by drugs used to treat diabetes, and cardiovascular and psychiatric illnesses. PhyzioType Systems are designed to provide physicians with an unprecedented capability to select for each patient the safest drug treatment to enhance compliance. Genomas is located in Hartford, CT on the campus of Hartford Hospital. Please visit www.genomas.net for more information.


'/>"/>
SOURCE Genomas
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Latest trinational report presents most complete picture of North American industrial pollution
2. Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281
3. United Spinal Association Presents The 2009 Independence Expo: Improving Life for the Disabled and the Aging
4. Sangamo BioSciences Presents Positive Phase 2 ZFP Therapeutic Data at ADA 2009
5. Frost & Sullivan Presents LG Electronics IRIS With the 2009 Global Iris Recognition Biometrics Market Customer Value Leadership of the Year Award
6. Sound Surgical Technologies Chief Technology Officer Presents Paper on Focused Ultrasound Technology
7. Prometheus Presents Proprietary Oncology Diagnostic Platform at ASCO Annual Meeting
8. Telik Presents Results at ASCO From ASSIST-5 Trial of TELCYTA in Platinum Refractory and Resistant Ovarian Cancer
9. Lumenis(R) Presents the SlimLine(TM) GI Laser Fiber: The Latest Advancement in Laser Lithotripsy for Gastroenterology
10. Delaware Urologic Associate's, Dr. Peter J. Muench, Presents Advances in Incontinence Treatment with a New Perspective and Outlook
11. AGA Institute presents cutting-edge research during DDW
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB ... Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards ... in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the placement ... Vice President of North American Capital Sales at HTG Molecular . ... in the commercialization of the HTG EdgeSeq system and associated reagents in North America. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... June 24, 2016 According to ... Type (Standard Pen Needles, Safety Pen Needles), Needle Length ... Growth Hormone), Mode of Purchase (Retail, Non-Retail) - Trends ... report studies the market for the forecast period of ... USD 2.81 Billion by 2021 from USD 1.65 Billion ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
Breaking Medicine Technology: