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Genmab Announces 2008 First Half Year Results
Date:8/27/2008

f 2008, Genmab achieved a number of business and scientific milestones, as follows:

We achieved a development milestone for ofatumumab (HuMax-CD20(R)) under the collaboration with GlaxoSmithKline (GSK). A milestone payment of DKK 29 million (USD 6 million) was triggered by the first patient participating in the Phase II study for the treatment of relapsing remitting multiple sclerosis (RRMS).

We announced a Phase I/II study to evaluate a subcutaneous route of administration of ofatumumab (HuMax-CD20(R)) in rheumatoid arthritis (RA).

We appointed David Eatwell as new Chief Financial Officer.

We initiated two Phase I/II studies of zalutumumab (HuMax-EGFr(TM)), one to treat colorectal cancer (CRC) and another study in combination with radiotherapy for the treatment of advanced head and neck cancer.

Subsequent to the balance sheet date:

We announced the positive top-line results from a Phase III pivotal study evaluating ofatumumab (HuMax-CD20(R)) in two groups of patients with chronic lymphocytic leukaemia (CLL). The study met the primary endpoint in both patient populations and the results from the secondary endpoints also supported the primary endpoint. This event also marked the achievement of a DKK 233 million (USD 49 million) milestone under the GSK collaboration agreement.

We announced plans to begin four studies of ofatumumab in CLL and NHL this year, including;

1) Phase III CLL front line chlorambucil combination study. This open-label, parallel-arm study will include 444 patients with previously untreated CLL.

2) Phase II CLL ofatumumab retreatment and maintenance treatment study. This study will examine the retreatment and maintenance treatment of refractory CLL patients who participated in the ongoing Phase III CLL study.

3) Phase II NHL ofatumumab retreatment and maintenance study. This study will examine the retreatment and maintenance treatment of refractory follicular NHL patients who p
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SOURCE Genmab A/S
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