Navigation Links
Genetics point to serious pregnancy complication
Date:11/15/2012

New research at the University of Adelaide has revealed a genetic link in pregnant mums - and their male partners - to pre-eclampsia, a life-threatening complication during pregnancy.

Pre-eclampsia involves high blood pressure and fluid retention and can cause damage to the kidneys and liver. About 7% of pregnancies are affected by pre-eclampsia.

In a paper now online in the journal Placenta ahead of print publication, the researchers say they have found a genetic variant involving the AGT2R gene, which may predispose women to pre-eclampsia.

However, the genetic variant is only associated with pre-eclampsia when the pregnant mother is overweight or obese.

"Being able to predict which women are at risk of pre-eclampsia is a very important goal in obstetrics," says Professor Claire Roberts from the University of Adelaide's Robinson Institute.

Professor Roberts, Dr Ang Zhou and Professor Gus Dekker from the Robinson Institute studied data from the SCOPE study, involving more than 2000 women and their partners in Adelaide, Australia and Auckland, New Zealand.

Women who developed pre-eclampsia who were also overweight or obese were twice as likely to carry the AGT2R gene variant than the common form of the gene. The male partners of women with pre-eclampsia were also twice as likely to carry the variant gene. Their babies were three times more likely to carry the variant.

"This is a condition that can run in families," Professor Roberts says. "With both the mother and the father passing on their variant genes to their children, this places the child at greater risk of parenting a pre-eclamptic pregnancy."

Professor Roberts says the genetic variant is linked with restricted blood flow to the placenta.

"Impaired blood flow in the uterine artery is characterized by a 'notching effect' that appears on a Doppler ultrasound at 20 weeks gestation. Uterine artery notching has previously been associated with pre-eclampsia, and this restricted blood flow is due to impaired placental development," Professor Roberts says.

The researchers say the genetic variant has only a subtle effect in women of normal weight, but in overweight and obese women it appears to independently contribute to the risk of pre-eclampsia.

"Understanding this association could help to predict which women are likely to develop pre-eclampsia," Professor Roberts says.

"However, it also helps to reinforce the message that a normal weight prior to pregnancy will lower the risk of serious complications - being overweight or obese increases the risk of complications."


'/>"/>

Contact: Claire Roberts
claire.roberts@adelaide.edu.au
61-883-133-118
University of Adelaide
Source:Eurekalert

Related medicine news :

1. Worlds largest respiratory genetics study launches on World COPD Day
2. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
3. Epigenetics emerges powerfully as a clinical tool
4. How genetics shape our addictions
5. Genetics Society of Americas Genetics journal highlights for September 2012
6. Marin Countys high breast cancer rate may be tied to genetics
7. American Society of Human Genetics to hold 2012 annual meeting, Nov. 6 to 10, in San Francisco
8. Stanford study shows opiates side effects rooted in patients genetics
9. Odds of quitting smoking affected by genetics
10. Brave New World of Genetics Requires Safeguards, Experts Say
11. Optogenetics project takes top NIDA Addiction Science Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and ... and financial preparation services, is providing an update on a charitable event that ... City Rescue is a locally recognized nonprofit that provides shelter and care for ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The American ... to become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer ... Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. ...
(Date:10/13/2017)... Ill. (PRWEB) , ... October ... ... Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer ... healthcare professionals on guideline updates for the primary prevention of cardiovascular diseases ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 11, 2017  True Health, a leader in ... effort during National Breast Cancer Awareness month to ... Research recently ... that more than 10 million American women are ... BRCA1 or BRCA2 and have not had testing. These ...
(Date:10/5/2017)... , Oct. 5, 2017  In response ... of Oral and Maxillofacial Surgeons (AAOMS) released prescribing ... – to be used as a first-line therapy ... Recognizing the ... AAOMS White Paper "Opioid Prescribing: Acute and Postoperative ...
(Date:10/2/2017)... Lilly and Company (NYSE: LLY ) will ... 2017 on Tuesday, October 24, 2017. Lilly will also ... investment community and media to further detail the company,s ... at 9 a.m. Eastern time. Investors, media and the ... conference call through a link that will be posted ...
Breaking Medicine Technology: