Navigation Links
Genetics of patterning the cerebral cortex
Date:10/13/2009

e but at different levels in a graded pattern. Testing this hypothesis required that Shen-ju Chou, Ph.D., a senior research associate in the O'Leary lab and first-author of this study, develop a novel genetically-engineered mouse to delete Lhx2 in a conditional fashion.

Shen-ju and two other members of O'Leary's research team, Carlos G. Perez Garcia, Ph.D. and Todd T. Kroll, Ph.D., then used this mouse line to delete Lhx2 at different times during embryonic development to assess whether Lhx2 had any say over the progenitors' fate in producing regions of the cerebral cortex.

When the researchers deleted Lhx2 from neuroepithelial cells before they made the transition into radial glia, the neocortex was transformed into a large, out-of-place olfactory cortex. But when they deleted Lhx2 just one day later the transformation did not occur, indicating that the progenitors' regional identity was fixed.

"These experiments show that Lhx2 regulates the regional fate decision of progenitors of the Emx1 lineage to generate neocortex or olfactory cortex" says Chou. "Lhx2 needs to be present in appropriate quantities during a critical window of time for progenitors to make the appropriate fate decision. Adds O'Leary, "This finding dovetails nicely with our previous study on Fgf10 by demonstrating that the critical time window for the regional fate decision determined by Lhx2 closes once neuroepithelial cells have made the transition to radial glia, a step regulated by Fgf10."

O'Leary's team plans to extend this work to determine the mechanism of action of Lhx2, and whether modulating Lhx2 levels can direct, or restrict, the differentiation of embryonic stem (ES) cells, or induced pluripotent stem (iPS) cells. This work will be important for developing strategies for brain repair.


'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Interleukin Genetics to Present Research Findings at Upcoming Medical Meetings
2. Feinstein Investigators Receive Federal GO Grant to Study the Genetics of Schizophrenia
3. The American Society of Human Genetics to Host Press Briefing on 'Personalized Medicine and the Future of Health Care Practice' at 59th Annual Meeting
4. Genetics Linked to Early Sexual Activity in Kids
5. VitaPath Genetics Raises $6M in Series A Round
6. The American Society of Human Genetics Hosts 59th Annual Meeting
7. Viral Genetics Completes Second Major Debt Conversion
8. The HRSA Genetics Collaboratives are Bringing Genetic and Newborn Screening Services to Local Communities Around the United States
9. Addario Lung Cancer Medical Institute Announces Diagnostic Screening and Clinical Research Collaborations With Response Genetics, Inc.
10. March of Dimes Celebrates 50th Anniversary of Genetics Short Course
11. Teen Behaviors Stem From Genetics, Environment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetics of patterning the cerebral cortex
(Date:4/17/2014)... specifically associated with the risk of a difficult-to-diagnose ... of all breast cancer cases. , The largest ... invasive lobular carcinoma, gives researchers important clues to ... breast cancer, which can be missed through screening. ... journal PloS Genetics , was co-led by ...
(Date:4/17/2014)... of the most popular vaccine brands for children may ... be overlooking some cost factors when choosing vaccines, driving ... option, according to a new study by University of ... can be driven by numerous factors," says Sheldon H. ... of computer science and of mathematics at the U. ...
(Date:4/17/2014)... the April issue of Experimental Biology and ... Drs. Rex Gaskins and Paul Kenis in the ... of the University of Illinois Urbana-Champaign describe their ... reactions underlie a variety of cell functions including ... these crucial roles in regulating normal cellular behavior, ...
(Date:4/17/2014)... recent papers by a University of Colorado School ... develop treatments or vaccines for Dengue fever, West ... disease-causing flaviviruses. , Jeffrey S. Kieft, PhD, associate ... School of Medicine and an early career scientist ... recently published articles in the scholarly journals ...
(Date:4/17/2014)... Le Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, ... the April issue of Nature Reviews Microbiology ... Dr. McCullers, a world-renowned infectious disease specialist, ... the University of Tennessee Health Science Center, analyzed ... 1918, 1957 and 1968 pandemics, as well as ...
Breaking Medicine News(10 mins):Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Study recalculates costs of combination vaccines 2Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:CU researchers discover target for treating dengue fever 2
... ... track essential health care readings such as blood pressure, blood sugar, and weight. Special website ... to their health care providers. , ... Cleveland, OH (PRWEB) June 3, 2009 -- President Obama has made it his pledge ...
... Scientific Experts Gather to Set New Direction and Collaboration ... International Hyperphagia Conference opens this week in Baltimore, MD ... solving hunger amid a global obesity epidemic. This conference ... disciplines from around the world to discuss developments and ...
... to reduce post-op pain and scarring , WEDNESDAY, ... technique shows promise in procedures such as weight-loss ... studies. , The technique, called Natural Orifice Translumenal ... laparoscopic surgery and offers a much faster recovery ...
... Members Complete Picture of Costs Associated with Medical Procedures ... -- Anthem Blue Cross announced today that ... in the following counties in the state: Ventura, Santa ... San Diego, Imperial County, Orange County, San Joaquin/Valley, North ...
... IMAGINE Software, a leading provider of ... within the IMAGINEradiology(TM) practice management system at IMAGINE,s 2009 ... , , The system received a number ... deployment and maintenance distribution through application virtualization; "I-Connect," ...
... Informatics Solution enables healthcare professionals to more immediately ... information , , WARRENDALE, Pa., June 3 ... an informatics application that enables healthcare professionals to ... radiology patients, contrast injections from nearly anywhere. This ...
Cached Medicine News:Health News:New Health Monitoring and Health Tracking Website, VitalsTracker.com, Helps Health Consumers Organize Important Medical Data 2Health News:First International Conference on Appetite Control Begins This Week 2Health News:Abdominal Surgery May Become Easier for Patients 2Health News:Abdominal Surgery May Become Easier for Patients 3Health News:Anthem Blue Cross in California Provides More Members With Access to Comprehensive Transparency Tool 2Health News:Anthem Blue Cross in California Provides More Members With Access to Comprehensive Transparency Tool 3Health News:IMAGINE Software Unveils Advanced IMAGINEradiology(TM) Features 2Health News:MEDRAD Introduces Manage.Report - Advances Evidence-Based Decision Making 2Health News:MEDRAD Introduces Manage.Report - Advances Evidence-Based Decision Making 3
(Date:1/15/2014)...  According to Millennium Research Group (MRG), the global ... the United States and European transcatheter ... moderately through 2022, with embolization particles representing one ... in drug-eluting beads (DEBs) and radioembolization spheres in ...
(Date:1/15/2014)... 15, 2014 Reportlinker.com announces that ... available in its catalogue: ... for Advanced Drug Delivery Systems -- ... http://www.reportlinker.com/p01941928/Global-Markets-and-Technologies-for-Advanced-Drug-Delivery-Systems----Focus-on-Routes-of-Administration.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology ...
(Date:1/14/2014)... North America,s leading business partnering event ... 30 th edition of its annual conference at the ... 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... specialty chemical companies will take part in the conference, which ...
Breaking Medicine Technology:US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2
... Like our coat apron, weight is ... hours of comfortable wear without fatigue. ... movement, our front closing special procedure ... "Velcro closures that make it a ...
... Aprons are the result of a technologically ... x-ray aprons. Constructed with a wear resistant, ... the Lead Free aprons exhibit the same ... Each apron weighs approximately 50% less than ...
... is the first objective measurement for ... peptide (BNP) ,Cardiac hormone produced by ... ventricular volume expansion and pressure overload. ... and diastolic dysfunction. The Triage BNP ...
... The Magnetom C! system features 270 accessibility ... with the smallest pole diameter available (54 ... of up to four coils, increased patient ... field strength is 0.35 Tesla. , ,The ...
Medicine Products: