Navigation Links
Genetics of children's brain tumor unlocked
Date:5/18/2010

Researchers have identified an important cancer gene that could lead to more effective drugs being developed to fight paediatric high grade glioma, a disease which currently has a poor prognosis.

The discovery, published in the Journal of Clinical Oncology, was one of a number of significant genetic differences found between the adult and youth form of the disease. Gliomas are the most common brain tumour in children.

Clinicians and scientists at The Institute of Cancer Research (ICR) and The University of Nottingham on behalf of the UK Children's Cancer and Leukaemia Group, and St Jude Children's Research Hospital in the US, conducted by far the most comprehensive analysis to date of paediatric high-grade glioma, making a detailed scan of the genome of 78 newly-diagnosed patients.

They compared these paediatric tumour samples with the genome of adult gliomas, looking through 500,000 individual pieces of DNA for variations in the number of copies of each. In paediatric gliomas, a gene called PDGFRA on chromosome 4q12 was commonly amplified and there were often extra copies of chromosome 1q. These changes are rarely seen in the adult form of the disease.

Clinical differences between gliomas in adults and youth had already been observed, for example growth in disparate areas of the brain, but this is the first study to establish that the underlying genetics differ.

"We found significant differences between the genomes of adult and young people's gliomas," says Dr Chris Jones, Leader of the Paediatric Molecular Pathology Team at the ICR. "This is an important finding because it means studies on adult gliomas cannot simply be applied to younger patients, and it has particular implications for drug trials."

The researchers also tracked gene activity in 53 of the tumour samples, and compared the results with adult gliomas. Paediatric glioma tumours that did not have the PDGFRA alteration were nevertheless found to have associated genes switched on, suggesting that this biological pathway is a key to the development of this childhood cancer. The PDGFRA gene carries instructions for making a protein found on the cell surface, which is part of a pathway that helps control cell growth, proliferation and survival processes that are commonly disrupted in cancer.

"This cancer gene is unusually active in paediatric high-grade gliomas and is likely to be an important drug target," said Professor Richard Grundy from the Children's Brain Tumour Research Centre at The University of Nottingham.

In addition, 10 children in the study had glioma that arose after they were treated with radiotherapy to the brain for a previous cancer. Analysis of these children's tumours revealed they had the gene alterations at even higher frequency than the other cancers studied, which had been triggered by other factors. The presence of these alterations irrespective of the trigger for the cancer also indicates that they are crucial to glioma development.

High grade gliomas account for about 75 to 80 per cent of primary malignant brain tumours cancer that originates in the brain. In the UK, about 4,550 adults and 350 children are diagnosed with brain tumours each year. Gliomas are the most common brain tumour in children, and aggressive gliomas can be very difficult to treat successfully 70 to 90 per cent of patients die within two years of diagnosis.


'/>"/>

Contact: Professor Richard Grundy
richard.grundy@nottingham.ac.uk
44-115-823-0620
University of Nottingham
Source:Eurekalert

Related medicine news :

1. Cancer genetics pioneer wins Margaret Kripke Legend Award
2. Mount Sinai School of Medicine Commencement Honors Leaders in Genetics and Global Health
3. Resveratrol Supplement Company RevGenetics Welcomes New Chief Science Officer
4. Genetics, Psychology May Trigger ADHD
5. Study finds changes in fetal epigenetics throughout pregnancy
6. Interleukin Genetics, Inc. and Stanford University Report Genetic Test Improves Weight Loss Success With Diets
7. Medco Acquires Leading Genetics Healthcare Company, DNA Direct
8. Chicago Cancer Genome Project studies genetics of 1,000 tumors
9. New License Agreement with University of Colorado Gives Viral Genetics, Inc., Right to Develop Cancer Therapies
10. Interleukin Genetics Receives Approval To Sell its PST(R) Periodontal Disease Genetic Test in New York
11. Well-tolerated radiotherapy provides longer life to patients with recurrent brain cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to ... unique items from across the nation, this holiday-themed event will raise funds and awareness ... VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... will be giving viewers the lowdown on sciatica in a new episode of ... that focuses on current events and innovation and investigates each subject in-depth with ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa ... contributed a medical article to the newly revamped Cosmetic Town journal ... the hair transplant procedure known as Follicular Unit Extraction (FUE). , ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Korea , Oct. 4, 2017  South Korean-based ... next-generation CPR training aide "cprCUBE" on Kickstarter. The device ... compression during cardiac arrests with better efficiency compared to ... also offers real-time feedback on efficacy of the compression ... crowdfunding campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, the ... by Walgreens and pharmacy benefit manager Prime Therapeutics LLC ... brand, which included the unveiling of new signage at ... as well as at a few other company-owned facilities ... brand to patients, some of whom will begin to ...
(Date:9/27/2017)... -- Commended for their devotion to personalized service, SMP Pharmacy Solutions ... in the South Florida Business Journal,s 50 Fastest-Growing Companies, and ... the national specialty pharmacy has found its niche.  To that ... be honored by SFBJ as the 2017 Power Leader in ... receive his award in October, Bardisa said of the three ...
Breaking Medicine Technology: