Navigation Links
Genetics of children's brain tumor unlocked
Date:5/18/2010

Researchers have identified an important cancer gene that could lead to more effective drugs being developed to fight paediatric high grade glioma, a disease which currently has a poor prognosis.

The discovery, published in the Journal of Clinical Oncology, was one of a number of significant genetic differences found between the adult and youth form of the disease. Gliomas are the most common brain tumour in children.

Clinicians and scientists at The Institute of Cancer Research (ICR) and The University of Nottingham on behalf of the UK Children's Cancer and Leukaemia Group, and St Jude Children's Research Hospital in the US, conducted by far the most comprehensive analysis to date of paediatric high-grade glioma, making a detailed scan of the genome of 78 newly-diagnosed patients.

They compared these paediatric tumour samples with the genome of adult gliomas, looking through 500,000 individual pieces of DNA for variations in the number of copies of each. In paediatric gliomas, a gene called PDGFRA on chromosome 4q12 was commonly amplified and there were often extra copies of chromosome 1q. These changes are rarely seen in the adult form of the disease.

Clinical differences between gliomas in adults and youth had already been observed, for example growth in disparate areas of the brain, but this is the first study to establish that the underlying genetics differ.

"We found significant differences between the genomes of adult and young people's gliomas," says Dr Chris Jones, Leader of the Paediatric Molecular Pathology Team at the ICR. "This is an important finding because it means studies on adult gliomas cannot simply be applied to younger patients, and it has particular implications for drug trials."

The researchers also tracked gene activity in 53 of the tumour samples, and compared the results with adult gliomas. Paediatric glioma tumours that did not have the PDGFRA alteration were nevertheless found to have associated genes switched on, suggesting that this biological pathway is a key to the development of this childhood cancer. The PDGFRA gene carries instructions for making a protein found on the cell surface, which is part of a pathway that helps control cell growth, proliferation and survival processes that are commonly disrupted in cancer.

"This cancer gene is unusually active in paediatric high-grade gliomas and is likely to be an important drug target," said Professor Richard Grundy from the Children's Brain Tumour Research Centre at The University of Nottingham.

In addition, 10 children in the study had glioma that arose after they were treated with radiotherapy to the brain for a previous cancer. Analysis of these children's tumours revealed they had the gene alterations at even higher frequency than the other cancers studied, which had been triggered by other factors. The presence of these alterations irrespective of the trigger for the cancer also indicates that they are crucial to glioma development.

High grade gliomas account for about 75 to 80 per cent of primary malignant brain tumours cancer that originates in the brain. In the UK, about 4,550 adults and 350 children are diagnosed with brain tumours each year. Gliomas are the most common brain tumour in children, and aggressive gliomas can be very difficult to treat successfully 70 to 90 per cent of patients die within two years of diagnosis.


'/>"/>

Contact: Professor Richard Grundy
richard.grundy@nottingham.ac.uk
44-115-823-0620
University of Nottingham
Source:Eurekalert

Related medicine news :

1. Cancer genetics pioneer wins Margaret Kripke Legend Award
2. Mount Sinai School of Medicine Commencement Honors Leaders in Genetics and Global Health
3. Resveratrol Supplement Company RevGenetics Welcomes New Chief Science Officer
4. Genetics, Psychology May Trigger ADHD
5. Study finds changes in fetal epigenetics throughout pregnancy
6. Interleukin Genetics, Inc. and Stanford University Report Genetic Test Improves Weight Loss Success With Diets
7. Medco Acquires Leading Genetics Healthcare Company, DNA Direct
8. Chicago Cancer Genome Project studies genetics of 1,000 tumors
9. New License Agreement with University of Colorado Gives Viral Genetics, Inc., Right to Develop Cancer Therapies
10. Interleukin Genetics Receives Approval To Sell its PST(R) Periodontal Disease Genetic Test in New York
11. Well-tolerated radiotherapy provides longer life to patients with recurrent brain cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... ... December 06, 2016 , ... Why does the prevalence of obesity continue to ... includes a fresh look into the cause of obesity in his new book “Body ... the knowledge needed to lead a healthy life. Proietto said understanding the regulation of ...
(Date:12/6/2016)... ... ... It can be argued that people these days spend as much time searching ... their human friends and family. As pets have assumed a bigger role in ... pet products has also increased. , For this reason, America’s Pet Health ...
(Date:12/6/2016)... ... December 06, 2016 , ... The Behavioral ... of Distinction, recognizing the organization as a top behavioral service provider in the ... of clinical quality, staff satisfaction and qualifications, and consumer satisfaction. These areas are ...
(Date:12/6/2016)... ... December 06, 2016 , ... Gateway Analytical, ... offering HIAC particle counting and sizing services for USP 788 and 789 particulate ... new service as a response to the needs of pharmaceutical and medical device ...
(Date:12/6/2016)... , ... December 06, 2016 ... ... on Friday, November 25th, when SevenPoint2 released the much-anticipated HydroFX for Water®. ... eye-catching label design. Featuring one of the world’s most powerful antioxidants, molecular ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... 2016  Viking Therapeutics, Inc. ("Viking") (NASDAQ: ... on the development of novel therapies for metabolic ... Food and Drug Administration (FDA) has granted orphan ... X-linked adrenoleukodystrophy (X-ALD).  VK0214 is a novel, orally ... regulates the expression of genes believed to be ...
(Date:12/6/2016)... 2016 Breast Pump Market size is estimated ... by Global Market Insights, Inc. Continue Reading ... ... , , ... women employment rates and rising consumer awareness regarding importance of breast feeding will ...
(Date:12/6/2016)... , Dec. 6, 2016 In this ... reason to be hopeful.  A special kind of sunglasses, ... less anxious life. Photo - ... Robert Buck, the psychotherapist who developed and patented ... approach to overcoming anxiety and worry.  "Anxiety doesn,t ...
Breaking Medicine Technology: