Navigation Links
Genetics of aging and cancer resistance
Date:11/14/2008

In the November 15th issue of G&D, Dr. Kenneth Dorshkind and colleagues at the David Geffen School of Medicine (UCLA) have identified two genes p16(Ink4a) and Arf that sensitize lymphoid progenitor cells to the effects of aging, and confer resistance to leukemogenesis.

Hematopoiesis (the development of blood cells) entails two main pathways: myelopoiesis (the formation of the red and white myeloid cells) and lymphopoiesis (the formation of B- and T-cells). While myelopoiesis remains constant throughout life, lymphopoiesis declines with age.

Dr. Dorshkind and colleagues demonstrated that older B lymphoid progenitor cells preferentially express p16(Ink4a) and Arf, which regulate cell cycle progression to effectively mediate senescence and tumor suppression in these aged cells. In contrast, myeloid progenitor cells consistently expressed much lower levels of these proteins.

The scientists showed that p16(Ink4a) and Arf contribute to the age-related decline in B-cell lymphopoiesis, and that inhibition of p16(Ink4a) and Arf in B-cell progenitors rejuvenates their growth potential and facilitates the development of acute lymphoblastic leukemia.

This newly established role for p16(Ink4a) and Arf linking the proliferative and oncogenic potential of B lymphoid progenitor cells lends genetic insight into the high incidence of lymphoid leukemias in younger patients, as well as the observation that adult leukemias generally involve the myeloid cell lineages.

As noted by the authors, "In addition to providing a basis for understanding the clinical presentation of lymphoid leukemias, these results raise the possibility that p16Ink4a and Arf may be potential therapeutic targets for rejuvenating the aged immune system".


'/>"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related medicine news :

1. Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery
2. New technique to study the genetics of breast cancer
3. Know the Myths and Facts About Family Health History: American College of Medical Genetics
4. Interleukin Genetics Announces Conference Call and Webcast to Discuss Third Quarter 2008 Business Results
5. Penn scientists map molecular regulation of fat-cell genetics
6. Interleukin Genetics to Present at Rodman & Renshaw 10th Annual Healthcare Conference
7. DNA Direct and Iverson Genetics Announce Partnership to Provide Personalized Patient Reports for Warfarin Dosing Test Results
8. Genetics, Environment Shape Sexual Behavior
9. Homosexual behavior due to genetics and environmental factors
10. 2008 Gruber Genetics Prize awarded to Allan Spradling of Carnegie Institution
11. 6 Nobel Prize Winners at International Congress of Genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... Demand Response Management Systems is a crucial peak ... imbalance between energy supply and demand. With the help ... (due to increasing pressure on the grid) and replaced ... residential appliances and thermostats for load reduction. , ... and with government mandates and benefits for energy efficiency ...
(Date:7/12/2014)... 2014 The fastest-growing mobile technology is ... measurement of LTE networks continues to grow due to ... devices have increased mobile data traffic, which is a ... market. Communications Test and Measurement equipment comply with industry ... Communications Test and Measurement Market is estimated to grown ...
(Date:7/12/2014)... Melbourne, Australia (PRWEB) July 12, 2014 ... past five years, despite rising competition from international and ... compound annual 2.9% over the five years through 2014-15. ... with consumers demanding more gaming services. Rises in discretionary ... have spent more money on non-essential items such as ...
(Date:7/12/2014)... July 12, 2014 (HealthDay News) -- Burn injuries increase in ... outdoor grills, say burn experts. Among those most vulnerable to ... the most vulnerable and often get burned by putting their ... Gamelli, director of the burn unit at Loyola University Medical ... "The old adage of ,When you play with fire, ...
(Date:7/12/2014)... Sean Francis, owner of the Kawartha Lakes Fit Body ... clients. He’s also known for his support of local non-profits like ... combine the two and is excited to announce that his ... Girls Club. , The funds are the result of Francis’ 21-Day ... sent out emails and asked his clients to put out the ...
Breaking Medicine News(10 mins):Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 4Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 5Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:Burn Injuries More Common in Summer 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 3
... claims that Maoris carry a "warrior" gene which make ... acts, terming such claims// as dangerous and inflammatory. ... at Environmental Science and Research, Dr Rod Lea and ... monoamine oxidase, often referred to as the warrior gene, ...
... be associated with suicide attempts and death in severely ... ,The U.S. Food and Drug Administration (FDA) recently ... the risk of suicidal behavior among children and teens ... trials revealed a potential link. It is uncertain whether ...
... new study has shown the children and teenagers who had ... less likely to be infected// than those who haven't been ... immunisation campaign that had taken place among the young New ... of acquiring Meningococcal B disease. The officials from the Ministry ...
... and transplant surgeon at the University of Cincinnati (UC) ... surgery. This procedure is a specialized surgery that removes ... The operation was done on a 2-year-old boy with ... Mexico City on May 24. ,Liver cancer ...
... School of Medicine in St. Louis claim that many ... treatment. Their finding is totally reverse of the claims ... researchers said that 50 percent of the children who ... ,"What we found was somewhat surprising," says ...
... Bahrain died, days before he was to return to India ... visa worker, Muthanna Poshanna, 46, died following complications from the ... report in the Gulf Daily News newspaper. ,Officials ... waiting for word from Poshanna's family in Andhra Pradesh on ...
Cached Medicine News:Health News:Warrior Gene Claims Slammed by Maori 2Health News:Warrior Gene Claims Slammed by Maori 3Health News:Antidepressants may be Linked with Suicide Attempts in Teens 2Health News:World’s First Pediatric Laparoscopic Liver Surger 2Health News:World’s First Pediatric Laparoscopic Liver Surger 3Health News:ADHD Children Are Being Under-Medicated 2Health News:ADHD Children Are Being Under-Medicated 3
(Date:7/10/2014)... Calif. , July 10, 2014  Breg, ... and services, has launched the FreeRunner™ knee brace ... who suffer from patella mal-tracking return to active ... differently than other braces, providing support when patients ... normally when they don,t. Patellofemoral issues ...
(Date:7/10/2014)... Pa. , July 10, 2014 ... Moberg Research,s (Moberg) medical device manufacturing facility. Rep. ... Moberg,s advanced neurological monitors facilitate cutting-edge research in ... Rep. Kennedy and mental health advocate, Garen ... organization dedicated to fostering fundamental changes that will ...
(Date:7/10/2014)... , July 10, 2014   Ventana Medical Systems, ... announced it has entered into an agreement with Merck ... as EMD Serono in the United States ... collaborate with Merck KGaA,s biopharmaceutical division on the development ... undisclosed target using Ventana,s proprietary diagnostic assays. In alignment ...
Breaking Medicine Technology:Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... Data to be presented November 2 at the American Society of Nephrology ... ... Calif., Oct. 16 ,Exelixis, Inc. (Nasdaq: EXEL ) announced that a ... of reducing proteinuria,compared with placebo in patients with proteinuria associated with diabetic,nephropathy. ...
... Concentra, the largest,occupational health care provider with ... to educate America,s workforce about the flu, how ... The company expects to vaccinate,nearly 300,000 people across ... lost productivity. Concentra Medical Centers offers flu ...
Cached Medicine Technology:Exelixis Reports Top-Line Results of the Phase 2 Trial of XL784 in Patients With Proteinuria Associated With Diabetic Nephropathy 2Exelixis Reports Top-Line Results of the Phase 2 Trial of XL784 in Patients With Proteinuria Associated With Diabetic Nephropathy 3Exelixis Reports Top-Line Results of the Phase 2 Trial of XL784 in Patients With Proteinuria Associated With Diabetic Nephropathy 4Concentra Offers Flu Vaccines to Keep America Working 2
... Combining exceptional new features ... XLTEKs latest innovation, the ... biphasic intracranial stimulation up ... 300 volts and transcranial ...
... high-volume analyzer that builds upon the field-proven ... and the latest Olympus technological advances. The ... with up to 147 on-board chemistries and ... Choose from Olympus 122 test menu, including ...
... e is designed for the ... laboratories and hospitals. Automate and consolidate ... reliability and Olympus 122 test menu, ... specific proteins, esoteric chemistries and tests ...
... is intended for the quantitative determination of Erythropoietin ... for in vitro diagnostic use, as an aid ... the advent of the administration of recombinant erythropoietin ... cell mass, an erythropoietin assay may be used ...
Medicine Products: