Navigation Links
Genetics may predict why calcium increases risk for prostate cancer
Date:9/16/2011

A study led by University of Southern California (USC) epidemiologists suggests that a high intake of calcium causes prostate cancer among African-American men who are genetically good absorbers of the mineral.

"High dietary intake of calcium has long been linked to prostate cancer and this study suggests that these associations are likely to be causal," said Sue Ann Ingles, Dr.P.H., associate professor of preventive medicine at the Keck School of Medicine of USC and principal investigator of the study. "At this point, however, we're not in a position to make any public health recommendations."

Ingles and colleagues at Wake Forest Baptist Medical Center and the Cancer Prevention Institute of California studied 783 African-American men living in the San Francisco and Los Angeles areas, 533 of whom were diagnosed with prostate cancer. They studied the effects of genotype, calcium intake and diet-gene interactions.

The study is one of the few to explore genes related to calcium absorption or to examine diet in a large African-American population. Although prostate cancer is 36 percent more common among African-Americans than in non-Hispanic whites, data on the diet-cancer link primarily comes from Caucasian populations. The team targeted a genetic allele that is more common in populations of African origin than in other populations and which is associated with regulating the absorption of calcium.

In the United States, more than 240,000 men are diagnosed annually with prostate cancer and about 33,720 die from the disease, according to the National Cancer Institute. Only lung cancer kills more American men. According to the Prostate Cancer Foundation, there are no proven strategies for preventing the disease, but changes in diet and lifestyle have shown to reduce the risk of disease progression.

The paper, published online by the Journal of Bone and Mineral Research in September, found that men who reported the highest intake of calcium were two times more likely to have localized and advanced prostate cancer than those who reported the lowest. Men with a genotype associated with poor calcium absorption were 59 percent less likely to have been diagnosed with advanced prostate cancer than men who genetically were the best absorbers of calcium. And, among men with calcium intake below the median, genetically poor absorbers had a 50 percent decreased risk of having advanced prostate cancer than the best absorbers.

The results pose somewhat of a "conundrum," Ingles said. Although calcium appears to increase risk for prostate cancer, it is essential for bone health and appears to protect against colorectal cancer, she said.

But African-Americans generally have strong and healthy bones and regular screening can help catch colorectal cancer, said first author Glovioell W. Rowland, Ph.D., a post-doctoral fellow in the Keck School's Department of Preventive Medicine.

"It may be possible in the future to personalize treatment by genotype," Rowland said. "But, first, our results have to be confirmed by studies of different races to indicate whether it's the allele that causes the disease or something else that's highly associated with African-American men."

Co-author Gary G. Schwartz, Ph.D., associate professor of cancer biology and epidemiology and prevention at Wake Forest Baptist, said the findings provide some clarity about the link between calcium and prostate cancer. Unlike age and race, which are fixed risk factors for prostate cancer, diet is modifiable.

"We now have a better understanding of why calcium in diet may increase the risk for prostate cancer and who is at increased risk," Schwartz said. "If our results are confirmed, it gives much better insight into the preventable causes of prostate cancer. So if I know I'm a good absorber of calcium, I may want to be careful about the use of calcium supplements."


'/>"/>

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California
Source:Eurekalert

Related medicine news :

1. Interleukin Genetics, Inc. and Stanford University Report Genetic Test Improves Weight Loss Success With Diets
2. Study finds changes in fetal epigenetics throughout pregnancy
3. Genetics, Psychology May Trigger ADHD
4. Resveratrol Supplement Company RevGenetics Welcomes New Chief Science Officer
5. Mount Sinai School of Medicine Commencement Honors Leaders in Genetics and Global Health
6. Cancer genetics pioneer wins Margaret Kripke Legend Award
7. Genetics of childrens brain tumor unlocked
8. Existence Genetics is Pioneering the Field of Predictive Medicine - Nexus Technologies Critical in Understanding and Preventing Deadly Disease
9. Genetics, Insecticides Might Contribute to Parkinsons
10. Can I buy you a drink? Genetics may determine sensitivity to other peoples drinking behavior
11. Perspectives on improving patient care: Genetics, personalized medicine, and behavioral intervention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
(Date:6/23/2016)... FRANKLIN, Tenn. , June 23, 2016 ... for automating, integrating and transforming the patient ... launch of several innovative new products and ... depth of its revenue cycle offerings. These ... establish more efficient workflows, remain compliant in ...
Breaking Medicine Technology: