Navigation Links
Genetics may predict why calcium increases risk for prostate cancer
Date:9/16/2011

A study led by University of Southern California (USC) epidemiologists suggests that a high intake of calcium causes prostate cancer among African-American men who are genetically good absorbers of the mineral.

"High dietary intake of calcium has long been linked to prostate cancer and this study suggests that these associations are likely to be causal," said Sue Ann Ingles, Dr.P.H., associate professor of preventive medicine at the Keck School of Medicine of USC and principal investigator of the study. "At this point, however, we're not in a position to make any public health recommendations."

Ingles and colleagues at Wake Forest Baptist Medical Center and the Cancer Prevention Institute of California studied 783 African-American men living in the San Francisco and Los Angeles areas, 533 of whom were diagnosed with prostate cancer. They studied the effects of genotype, calcium intake and diet-gene interactions.

The study is one of the few to explore genes related to calcium absorption or to examine diet in a large African-American population. Although prostate cancer is 36 percent more common among African-Americans than in non-Hispanic whites, data on the diet-cancer link primarily comes from Caucasian populations. The team targeted a genetic allele that is more common in populations of African origin than in other populations and which is associated with regulating the absorption of calcium.

In the United States, more than 240,000 men are diagnosed annually with prostate cancer and about 33,720 die from the disease, according to the National Cancer Institute. Only lung cancer kills more American men. According to the Prostate Cancer Foundation, there are no proven strategies for preventing the disease, but changes in diet and lifestyle have shown to reduce the risk of disease progression.

The paper, published online by the Journal of Bone and Mineral Research in September, found that men who reported the highest intake of calcium were two times more likely to have localized and advanced prostate cancer than those who reported the lowest. Men with a genotype associated with poor calcium absorption were 59 percent less likely to have been diagnosed with advanced prostate cancer than men who genetically were the best absorbers of calcium. And, among men with calcium intake below the median, genetically poor absorbers had a 50 percent decreased risk of having advanced prostate cancer than the best absorbers.

The results pose somewhat of a "conundrum," Ingles said. Although calcium appears to increase risk for prostate cancer, it is essential for bone health and appears to protect against colorectal cancer, she said.

But African-Americans generally have strong and healthy bones and regular screening can help catch colorectal cancer, said first author Glovioell W. Rowland, Ph.D., a post-doctoral fellow in the Keck School's Department of Preventive Medicine.

"It may be possible in the future to personalize treatment by genotype," Rowland said. "But, first, our results have to be confirmed by studies of different races to indicate whether it's the allele that causes the disease or something else that's highly associated with African-American men."

Co-author Gary G. Schwartz, Ph.D., associate professor of cancer biology and epidemiology and prevention at Wake Forest Baptist, said the findings provide some clarity about the link between calcium and prostate cancer. Unlike age and race, which are fixed risk factors for prostate cancer, diet is modifiable.

"We now have a better understanding of why calcium in diet may increase the risk for prostate cancer and who is at increased risk," Schwartz said. "If our results are confirmed, it gives much better insight into the preventable causes of prostate cancer. So if I know I'm a good absorber of calcium, I may want to be careful about the use of calcium supplements."


'/>"/>

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California
Source:Eurekalert

Related medicine news :

1. Interleukin Genetics, Inc. and Stanford University Report Genetic Test Improves Weight Loss Success With Diets
2. Study finds changes in fetal epigenetics throughout pregnancy
3. Genetics, Psychology May Trigger ADHD
4. Resveratrol Supplement Company RevGenetics Welcomes New Chief Science Officer
5. Mount Sinai School of Medicine Commencement Honors Leaders in Genetics and Global Health
6. Cancer genetics pioneer wins Margaret Kripke Legend Award
7. Genetics of childrens brain tumor unlocked
8. Existence Genetics is Pioneering the Field of Predictive Medicine - Nexus Technologies Critical in Understanding and Preventing Deadly Disease
9. Genetics, Insecticides Might Contribute to Parkinsons
10. Can I buy you a drink? Genetics may determine sensitivity to other peoples drinking behavior
11. Perspectives on improving patient care: Genetics, personalized medicine, and behavioral intervention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... April 25, 2017 , ... A stressful work environment ... can also decrease overall productivity and performance in the workplace. The goal of Clearview ... the last few weeks of April, Clearview Resolution Services will be shutting down the ...
(Date:4/25/2017)... ... April 25, 2017 , ... A ... student test score performance for the 2015-16 school year across Wisconsin’s public schools, ... Though it highlights important patterns in student test score performance, the report’s limited ...
(Date:4/25/2017)... ... April 25, 2017 , ... Lake Park Dental is ... using Invisalign® in Lutz, FL. With the help of this highly-effective, yet ... with fewer potential complications, more discretion and less pain. , Drs. Sarah Jockin, ...
(Date:4/25/2017)... ... April 25, 2017 , ... As pharmaceutical companies are held ... with process innovation in drug formulation and manufacturing. CoreRx offers its clients ... equipment in support of their development and manufacturing goals. , The company ...
(Date:4/25/2017)... ... , ... Back Pain Centers of America (BPC), which connects people ... their area, announces the launch of a new and proprietary customer relationship management (CRM) ... reputable physicians to help them with back or neck pain and helps to match ...
Breaking Medicine News(10 mins):
(Date:4/24/2017)... April 24, 2017 Solentim, the developer ... the addition of a major new product line ... Seeding,). The VIPS has been developed for automatically ... microplates as part of the process to generate ... simple and more reliable solution when compared to ...
(Date:4/20/2017)... 20, 2017  Vivify Health, the pioneer and market ... awarded a very significant patent for the advancement of ... care via digital health.  This landmark patent provides the ... further secures Vivify,s position as the leader in remote ... the first company to apply consumer mobile devices, wireless ...
(Date:4/20/2017)... MARLBOROUGH, Mass. , April 20, 2017 /PRNewswire/ ... company developing innovative therapeutics that address significant unmet ... new data from the Company,s consumer product development ... technology, at the Society for Investigative Dermatology (SID) ... is to advance and promote the sciences relevant ...
Breaking Medicine Technology: