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Genetics Society of America's Genetics journal highlights for September 2012
Date:9/10/2012

Bethesda, MDSeptember 10, 2012 Listed below are the selected highlights for the September 2012 issue of the Genetics Society of America's journal, GENETICS. The September issue is available online at www.genetics.org/content/current. Please credit GENETICS, Vol. 192, September 2012, Copyright 2012.

ISSUE HIGHLIGHTS

Weak selection and protein evolution, pp. 15-31
Hiroshi Akashi, Naoki Osada, and Tomoko Ohta
The rapid proliferation of genome sequence data has renewed interest in the causes of molecular evolution. The authors review the basis of the "nearly neutral" theory of molecular evolution, which proposes that the interaction of genetic drift and weak natural selection is prevalent in genome evolution. They review abundant evidence from population genetic and comparative genomic analyses that supports weak selection, but they also discuss overlapping predictions from other models.

Mapping quantitative trait loci onto a phylogenetic tree, pp. 267-279
Karl W. Broman, Sungjin Kim, Śaunak Sen, Ccile An, and Bret A. Payseur
Mapping of quantitative trait loci (QTL) can be aided by considering multiple crosses among related taxa. That approach also offers the opportunity to identify the origin of a QTL allele on the phylogenetic tree. These authors describe a method for this kind of analysis and discuss experimental design issues for such endeavors. They explore the method's performance in computer simulations, and illustrate its use through application to data on HDL cholesterol from a set of four mouse intercrosses among five inbred strains.

Genome rearrangements caused by depletion of essential DNA replication proteins in Saccharomyces cerevisiae, pp. 147-160
Edith Cheng, Jessica A. Vaisica, Jiongwen Ou, Anastasia Baryshnikova, Yong Lu, Frederick P. Roth, and Grant W. Brown '/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

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