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Genetics Society of America's Genetics journal highlights for December 2012
Date:12/4/2012

mohiko Kubo
Plant pollen production is often impaired by incompatibility between the mitochondria and nucleus. A nuclear gene termed Rf can cancel this cytoplasmic male sterility. These authors report that sugar beet Rf encodes a metalloprotease-like gene, in contrast to other Rfs which encode proteins supposed to bind RNA. Interestingly, the sugar beet Rf locus exhibits the gene clustering often seen in plant Rf loci, suggesting a common evolutionary mechanism regardless of the Rf gene products.

CloudMap: A cloud-based pipeline for analysis of mutant genome sequences, pp. 1249-1269
Gregory Minevich, Danny S. Park, Daniel Blankenberg, Richard J. Poole, and Oliver Hobert
This article describes a cloud-based data-analysis pipeline that greatly simplifies analysis of mutant genome sequences. Available on the Galaxy platform, CloudMap requires no software installation and is modular, and thus able to accommodate new software tools as they become available. CloudMap uses a series of predefined workflows, allowing users to arrive at a mapping region and a list of variants with a few clicks.

Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase Tip60 controls sleep, pp. 1327-1345
Sheila K. Pirooznia, Kellie Chiu, May T. Chan, John E. Zimmerman, and Felice Elefant
This article provides insight into sleep disturbances caused by neurodegenerative diseases. In Drosophila, misregulation of the histone acetyltransferase Tip60 causes sleep disturbances similar to those seen in Alzheimer's disease patients, with nighttime sleep disruption and daytime sleepiness. These authors show that Tip60 interacts with amyloid precursor protein (APP) to mediate axonal growth of Drosophila pacemaker cells and their production of a neuropeptide that stabilizes sleepwake cycles. Remarkably, excess Tip60 rescues sleep disruption caused by APP-induced neurodegenerative conditions.

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Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

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