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Genetics Society of America's Genetics journal highlights for December 2012
Date:12/4/2012

Bethesda, MDDecember 4, 2012 Listed below are the selected highlights for the December 2012 issue of the Genetics Society of America's journal, Genetics. The December issue is available online at www.genetics.org/content/current. Please credit Genetics, Vol. 192, December 2012, Copyright 2012.

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ISSUE HIGHLIGHTS

Genetic variation in Saccharomyces cerevisiae: Circuit diversification in a signal transduction network, pp. 1523-1532
Brian L. Chin, Owen Ryan, Fran Lewitter, Charles Boone, and Gerald R. Fink
The plummeting cost of genome sequencing has revealed increasing amounts of genetic variation within a species. How much of that variation affects function, and how might it help us understand evolution? The authors addressed these questions by looking at how cell adhesion is controlled in two closely related yeast strains. Despite their similar genomic sequences, these two strains use different sets of genes to regulate adhesion. A signal transduction pathway has been rewired, partly because of polymorphisms in a transcription factor.

Gene functional trade-offs and the evolution of pleiotropy, pp. 1389-1409
Frdric Guillaume and Sarah P. Otto
Pleiotropythe property of genes affecting multiple features of an organismis often considered to be an unavoidable by-product of a gene's evolutionary history. These authors explored how the pleiotropic degree of a gene may evolve, providing clues to why pleiotropy varies among genes. They found two common outcomes of the evolution of multifunctional genes: increased pleiotropy of genes more highly expressed, and specialization of all genes on the trait most important to fitness.

Receptors and other signaling proteins required for serotonin control of locomotion in Cae
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Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

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