Navigation Links
Genetics Should Decide Warfarin Dose, Study Reiterates
Date:3/20/2009

What works for some people might be dangerous for others,,

FRIDAY, March 20 (HealthDay News) -- Researchers have confirmed previously reported genetic factors that may help doctors more accurately prescribe the proper dosage of the blood thinner warfarin to people at high risk of cardiovascular problems.

According to U.S. Food and Drug Administration estimates, about 2 million Americans use the anticoagulant medication to prevent blood clots and reduce the likelihood of a stroke, pulmonary embolism or heart attack.

Though the drug can be very effective, the optimal therapeutic dosage varies as much as 20-fold among individuals, with too high a dose risking severe bleeding and too small a dose failing to protect against the original cardiovascular worry. Trial and error followed by frequent monitoring of blood levels have been the common method of determining the proper dose for a given person.

Researchers from Sweden and the United Kingdom, studying the genetic makeup of more than 1,000 warfarin users, reported finding three genes -- VKORC1, CYP2C9 and CYP4F2 -- with common variants that explain more than 40 percent of the variability in optimal dosing levels. VKORC1, which affects the liver's ability to use and excrete warfarin, and CYP2C9, which helps with the essential blot-clotting vitamin K, were found to be responsible for the vast majority of the variability, according to the study. The findings were to be published March 20 in PLoS Genetics.

The finding appears to support a study in the Feb. 19 issue of the New England Journal of Medicine. In that report, American researchers collected data -- including the VKORC1 and CYP2C9 variants -- from more than 4,000 people taking warfarin and created an algorithm that had a high rate of success predicting the ideal dose of the drug.

More information

The U.S. National Library of Medicine has more about warfarin.



-- Kevin McKeever



SOURCES: PLoS Genetics, news release, March 19, 2009; New England Journal of Medicine, Feb. 19, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Genetics Hold Promise, Challenges for Cancer Care
2. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
3. Salugen to Present Research on Generational Associations of Reward Deficiency Syndrome at XVth World Congress on Psychiatric Genetics
4. Obesity genetics
5. The genetics of MLL leukemogenesis
6. Vanda Pharmaceuticals to Present New Data on Iloperidone at the 2007 American Society of Human Genetics Annual Meeting
7. Clarient Names Michele Hibbard, Ph.D. Director of Genetics
8. Response Genetics Announces Presentation/Webcast at BIOCOM Investor Conference
9. Interleukin Genetics to Host Third Quarter 2007 Financial Results Conference Call November 7
10. Response Genetics to Announce Third Quarter 2007 Financial Results on Wednesday, November 14, 2007
11. Response Genetics Reports Third Quarter 2007 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetics Should Decide Warfarin Dose, Study Reiterates
(Date:12/5/2016)... ... December 05, 2016 , ... ... and relationship-marketing firm, announced today that nominations will be accepted from December ... (ISE®) Central Awards. , Awards include the Information Security Executive® of the ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... Meeting through tomorrow, December 6th, sparks a conversation about epilepsy, bearing down on ... in 26 people will be diagnosed with epilepsy within their lifetime. With such ...
(Date:12/5/2016)... , ... December 05, 2016 ... ... interoperability, today announced that the company will provide alerting technology to Central ... been recently awarded $1.7 million in federal funds as the sole sub-recipient ...
(Date:12/5/2016)... ... December 05, 2016 , ... Dr. Barry M. Weintraub, one ... Surgery, who recently participated in the 36th Annual Cutting Edge Aesthetic Symposium at the ... techniques for getting that perfect, yet natural-looking, nose. Dr. Weintraub, who is world-renowned for ...
(Date:12/5/2016)... , ... December 05, 2016 , ... ... Officer for the Florida Hospital West Florida Region. McGuinness brings experience in executive ... and engaging staff, physicians and leaders. , In her new role, that officially ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Dec. 5, 2016  BD (Becton, Dickinson ... global medical technology company, will demonstrate an enhanced technology ... management technologies, including the company,s leading Pyxis™ and Alaris™ ... Pharmacists (ASHP) 2016 Midyear Meeting being held in ... While national data show that approximately 68 ...
(Date:12/5/2016)... Research and Markets has announced the addition of the "Global ... and Demand Forecast to 2022" report to their offering. ... , , ... market is expected to grow at a CAGR of 4.5% during ... witnessing high growth, due to growing female geriatric population and increasing ...
(Date:12/5/2016)... England , December 5, 2016 ... Transitions to Deputy Chairman   ... on selectively targeting deubiquitylating enzymes (DUBs) to treat cancer, neurodegenerative ... has been appointed as non-executive Chairman, effective January 1 st ... of Mission Therapeutics as a non-executive Director in July 2015. ...
Breaking Medicine Technology: