Navigation Links
Genetics May Determine Antidepressants' Effectiveness
Date:1/23/2008

German researchers identify 11 variants that seem to influence outcome

WEDNESDAY, Jan. 23 (HealthDay News) -- Genetic variations that predict patient response to the two common antidepressant drugs citalopram (brand name Celexa) and venlafaxine (Effexor) have been identified by German researchers.

The team at the Max Planck Institute of Psychiatry in Munich found that 11 variants in the gene for a protective transporter protein called P-gp, which removes drugs and other substances from the brain, compromise the effectiveness of these two drugs.

In the first part of the study, the researchers knocked out genes for P-gp in mice and gave them antidepressants. They found that brain concentrations of citalopram and venlafaxine were regulated by P-gp, indicating that the antidepressants were "substrates" of the transporter protein.

Next, the team analyzed 443 people on antidepressants for genetic variants that correlated with reduced efficacy of the two antidepressants.

"To our knowledge, our results provide for the first time evidence that genetic variants in the (gene for P-gp) account for differences in the clinical efficacy of antidepressants, most likely by influencing their access to the brain," the researchers wrote.

The findings, published in the Jan. 24 issue of the journal Neuron, suggest that genetic testing could help predict how individual patients would react to specific antidepressants, the researchers said.

They added that genetic tests may also help predict the effectiveness of any drugs used to treat neurological diseases.

"The general conclusion to be drawn is that any drug treatment administered to treat CNS (central nervous system) diseases should be analyzed for its P-gp substrate status, which can be determined by using knockout mice. From a clinical point of view, the findings warrant that patients receiving a drug that is a P-gp substrate for the treatment of brain diseases are genotyped to exclude the possibility that a patient receives a drug that fails to enter the CNS to an extent required for efficacy," the study authors wrote.

Future development of antidepressants should take into account whether new drugs are transported by P-gp, and clinical trials of antidepressant drugs need to factor in the P-gp genetic status of participants, the researchers recommended.

More information

The U.S. National Institute of Mental Health has more about depression.



-- Robert Preidt



SOURCE: Cell Press, news release, Jan. 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Genetics Influence Blood Pressure Medications
2. People with anorexia less likely to be blamed when biology, genetics explained
3. Top10 research advances include studies on genetics and stem cell research, stents
4. Heart attack risk from smoking due to genetics
5. Genetics May Boost Mexican-Americans Risk for Alcoholism
6. Targeted Genetics Reports on Recombinant DNA Advisory Committee (RAC) Assessment of Its Phase I/II Trial of tgAAC94 for Inflammatory Arthritis
7. Researchers develop powerful tool to study the genetics of inflammation
8. deCODE genetics to Webcast Presentation at Piper Jaffray Annual Healthcare Conference
9. deCODE genetics to Webcast Presentation at Lazard Capital Markets Annual Healthcare Conference
10. Genetics and Risk, This Week on Your Cancer Today(TM)
11. CellCyte Genetics Corp. Appoints Tony Colasin as Director of Business Development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetics May Determine Antidepressants' Effectiveness
(Date:1/19/2017)... ... January 19, 2017 , ... ... offering treatments for patients with sleep apnea and TMJ disorders. These conditions are ... physical health. Dr. Rassouli provides personalized care to reduce the risk of these ...
(Date:1/19/2017)... ... ... Allegheny Health Network (AHN) officials today announced a bold new step to greatly ... in the greater Pittsburgh region. Starting January 23, patients who call AHN by 11 ... afternoon. , AHN is the first healthcare provider in the region ...
(Date:1/19/2017)... VA (PRWEB) , ... January 19, 2017 , ... Tribble ... services to the eastern Virginia region, is inaugurating a charity event to honor Chad ... , While on duty last year, Chad Phillip Dermyer and his fellow officers were ...
(Date:1/19/2017)... Antonio, TX (PRWEB) , ... January 19, 2017 , ... ... has for the fifth consecutive year donated money to the Triumph Over Kid Cancer ... A. Ragan was one of those children. James saw firsthand the effect of the ...
(Date:1/19/2017)... (PRWEB) , ... January 18, 2017 , ... The CHP ... driving during a rain storm by slowing down and increasing the space between themselves ... 40. Los Angeles based car accident attorney Raymond R. Hassanlou notes that, rain or ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Md. , Jan. 19, 2017 The U.S. ... treatment of Chronic Idiopathic Constipation (CIC) in adult patients. ... from chronic gastrointestinal disorders," said Julie Beitz , M.D., ... FDA,s Center for Drug Evaluation and Research. "With the availability ... most appropriate treatment for their condition." ...
(Date:1/19/2017)... YORK , Jan. 19, 2017 This ... the current and future scenario of the global market. ... rising opioid consumption. Severe chronic constipation is a major ... to traditional laxatives. Hence, novel targeted therapy has been ... OIC sufferers, launch of targeted medicines, and growing awareness ...
(Date:1/19/2017)... LONDON , January 19, 2017 Incretin ... Sympathomimetics and Others The global anti-obesity drugs ... the first half of the forecast period and CAGR of 38.7% ... expected to grow at a CAGR of 32.8% from 2016 to ... million in 2021, and $24,063 million in 2027. ...
Breaking Medicine Technology: