Navigation Links
Genetics May Determine Antidepressants' Effectiveness
Date:1/23/2008

German researchers identify 11 variants that seem to influence outcome

WEDNESDAY, Jan. 23 (HealthDay News) -- Genetic variations that predict patient response to the two common antidepressant drugs citalopram (brand name Celexa) and venlafaxine (Effexor) have been identified by German researchers.

The team at the Max Planck Institute of Psychiatry in Munich found that 11 variants in the gene for a protective transporter protein called P-gp, which removes drugs and other substances from the brain, compromise the effectiveness of these two drugs.

In the first part of the study, the researchers knocked out genes for P-gp in mice and gave them antidepressants. They found that brain concentrations of citalopram and venlafaxine were regulated by P-gp, indicating that the antidepressants were "substrates" of the transporter protein.

Next, the team analyzed 443 people on antidepressants for genetic variants that correlated with reduced efficacy of the two antidepressants.

"To our knowledge, our results provide for the first time evidence that genetic variants in the (gene for P-gp) account for differences in the clinical efficacy of antidepressants, most likely by influencing their access to the brain," the researchers wrote.

The findings, published in the Jan. 24 issue of the journal Neuron, suggest that genetic testing could help predict how individual patients would react to specific antidepressants, the researchers said.

They added that genetic tests may also help predict the effectiveness of any drugs used to treat neurological diseases.

"The general conclusion to be drawn is that any drug treatment administered to treat CNS (central nervous system) diseases should be analyzed for its P-gp substrate status, which can be determined by using knockout mice. From a clinical point of view, the findings warrant that patients receiving a drug that is a P-gp substrate for the treatment of brain diseases are genotyped to exclude the possibility that a patient receives a drug that fails to enter the CNS to an extent required for efficacy," the study authors wrote.

Future development of antidepressants should take into account whether new drugs are transported by P-gp, and clinical trials of antidepressant drugs need to factor in the P-gp genetic status of participants, the researchers recommended.

More information

The U.S. National Institute of Mental Health has more about depression.



-- Robert Preidt



SOURCE: Cell Press, news release, Jan. 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Genetics Influence Blood Pressure Medications
2. People with anorexia less likely to be blamed when biology, genetics explained
3. Top10 research advances include studies on genetics and stem cell research, stents
4. Heart attack risk from smoking due to genetics
5. Genetics May Boost Mexican-Americans Risk for Alcoholism
6. Targeted Genetics Reports on Recombinant DNA Advisory Committee (RAC) Assessment of Its Phase I/II Trial of tgAAC94 for Inflammatory Arthritis
7. Researchers develop powerful tool to study the genetics of inflammation
8. deCODE genetics to Webcast Presentation at Piper Jaffray Annual Healthcare Conference
9. deCODE genetics to Webcast Presentation at Lazard Capital Markets Annual Healthcare Conference
10. Genetics and Risk, This Week on Your Cancer Today(TM)
11. CellCyte Genetics Corp. Appoints Tony Colasin as Director of Business Development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetics May Determine Antidepressants' Effectiveness
(Date:9/24/2017)... Caicos Islands, BWI (PRWEB) , ... September 24, 2017 , ... ... #1 rated resort on TripAdvisor and one of Provo's premier boutique resorts, is planning ... structural damage to the resort after devastating Hurricanes Irma and more recently Hurricane Maria, ...
(Date:9/24/2017)... (PRWEB) , ... September 24, 2017 , ... In “Sky and I”, a young boy was walking home and feeling ... friend who tells him otherwise. The new friend says he can do whatever he wants ... special and good enough just the way he is. God created him with special talents ...
(Date:9/23/2017)... Los Angeles, California (PRWEB) , ... September 23, ... ... Chicago Tribune discusses the behavioral approach to fighting obesity of Robert Kushner, director ... holistic approach to weight loss and promoting healthier habits, the article notes that ...
(Date:9/22/2017)... ... September 22, 2017 , ... MEDIA OPPORTUNITY: , Save Our Hospital - ... on why they are rallying against Mayo Clinic. Specifically, media can talk to steering ... Noseworthy’s (CEO) decision to close the Albert Lea hospital. , The rally aims to ...
(Date:9/22/2017)... ... September 22, 2017 , ... Fenwick Agency of Plano, TX has announced the ... part of the nationally recognized ‘Agents of Change’ movement. The agency pledges to select ... leaders to seek out those who most need help. Their hope is to bring ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... LONDON , Sept. 5, 2017  Just 18 ... Valid Insight is pleased to announce the appointment of ... Tammy Wynne , Dominic Jones-Phillips and ... from industry. ... a team of market access writers. She has over ...
(Date:9/1/2017)... 1, 2017  Bayer will present the latest research from ... Medical Oncology (ESMO) 2017 Congress, September 8-12 in ... preclinical and clinical data on Bayer,s marketed portfolio and late-stage ... "We value the ... cancer research at ESMO," said Carsten Brunn , Head ...
(Date:8/28/2017)... 28, 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... September 11, 2017, in New York . ... is scheduled to present at 11:05 a.m. Eastern Time. ... http://ir.hill-rom.com/events.cfm . A recorded replay will be available one ... 10, 2017. About ...
Breaking Medicine Technology: