Navigation Links
Genetics May Determine Antidepressants' Effectiveness
Date:1/23/2008

German researchers identify 11 variants that seem to influence outcome

WEDNESDAY, Jan. 23 (HealthDay News) -- Genetic variations that predict patient response to the two common antidepressant drugs citalopram (brand name Celexa) and venlafaxine (Effexor) have been identified by German researchers.

The team at the Max Planck Institute of Psychiatry in Munich found that 11 variants in the gene for a protective transporter protein called P-gp, which removes drugs and other substances from the brain, compromise the effectiveness of these two drugs.

In the first part of the study, the researchers knocked out genes for P-gp in mice and gave them antidepressants. They found that brain concentrations of citalopram and venlafaxine were regulated by P-gp, indicating that the antidepressants were "substrates" of the transporter protein.

Next, the team analyzed 443 people on antidepressants for genetic variants that correlated with reduced efficacy of the two antidepressants.

"To our knowledge, our results provide for the first time evidence that genetic variants in the (gene for P-gp) account for differences in the clinical efficacy of antidepressants, most likely by influencing their access to the brain," the researchers wrote.

The findings, published in the Jan. 24 issue of the journal Neuron, suggest that genetic testing could help predict how individual patients would react to specific antidepressants, the researchers said.

They added that genetic tests may also help predict the effectiveness of any drugs used to treat neurological diseases.

"The general conclusion to be drawn is that any drug treatment administered to treat CNS (central nervous system) diseases should be analyzed for its P-gp substrate status, which can be determined by using knockout mice. From a clinical point of view, the findings warrant that patients receiving a drug that is a P-gp substrate for the t
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Genetics Influence Blood Pressure Medications
2. People with anorexia less likely to be blamed when biology, genetics explained
3. Top10 research advances include studies on genetics and stem cell research, stents
4. Heart attack risk from smoking due to genetics
5. Genetics May Boost Mexican-Americans Risk for Alcoholism
6. Targeted Genetics Reports on Recombinant DNA Advisory Committee (RAC) Assessment of Its Phase I/II Trial of tgAAC94 for Inflammatory Arthritis
7. Researchers develop powerful tool to study the genetics of inflammation
8. deCODE genetics to Webcast Presentation at Piper Jaffray Annual Healthcare Conference
9. deCODE genetics to Webcast Presentation at Lazard Capital Markets Annual Healthcare Conference
10. Genetics and Risk, This Week on Your Cancer Today(TM)
11. CellCyte Genetics Corp. Appoints Tony Colasin as Director of Business Development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetics May Determine Antidepressants' Effectiveness
(Date:6/1/2015)... The Delta Dental Foundation is currently seeking applications ... Ohio and Indiana for its Brighter Futures Community Grants ... been set. , Across the tri-state area, the program ... focus on children’s oral health and $100,000 in grants ... Each grant request will be considered and carefully reviewed ...
(Date:6/1/2015)... (PRWEB) June 01, 2015 On May ... Care center hosted the Cherry Creek Chamber of ... care clinic. Urgent care centers typically do not offer ... allow AFC/Doctors Express Cherry Creek Urgent Care staff to ... physicals. , From 5:30 to 7:30 p.m. the center ...
(Date:6/1/2015)... Cambia Health Solutions and America’s Health ... Affordable Care Act (ACA) training course to engage ... Care Act Expert Series, Large Group Training,” provides ... insights necessary to effectively engage and support large ... the ACA. , The interactive, experience-based course includes:, ...
(Date:6/1/2015)... Note: Dr. Julian is available for interviews today ... A phase III trial funded by the National Institutes ... in situ (DCIS) now have an additional tool for ... B-35/NRG Oncology) looked at more than 3,000 DCIS survivors, ... tamoxifen to those who completed five years of the ...
(Date:6/1/2015)... More than 22 million children may miss ... is out and they lose access to free or reduced-price ... farmers and milk companies are on a mission to bring ... American Milk Drive. , In many cases, food insecure ... cafeteria for the bulk of their daily nutrition. Although the ...
Breaking Medicine News(10 mins):Health News:Brighter Futures Community Grants Program Seeks to Help Fund Local Oral Health Programs 2Health News:Grand Opening For AFC/Doctors Express Cherry Creek Primary Care Clinic 2Health News:Cambia Partners with AHIP to Offer Expert Series ACA Training Course 2Health News:Cambia Partners with AHIP to Offer Expert Series ACA Training Course 3Health News:Today at ASCO: Anastrazole Offers Higher Breast Cancer-Free Survival Rates than Tamoxifen Following DCIS, Phase III Study Shows 2Health News:Today at ASCO: Anastrazole Offers Higher Breast Cancer-Free Survival Rates than Tamoxifen Following DCIS, Phase III Study Shows 3Health News:Summer Nutrition Vital for Kids who Depend on Schools for Healthy Foods 2
... Using spices eaten in the Mediterranean diet as natural antioxidants ... the beneficial health effects of these products. This has been ... have put the clove in first place. Researchers from ... ) as the best antioxidant spice, due to the fact ...
... , ... available April 1 , ... N.C. (Vocus) March 16, 2010 -- Prodigy Diabetes Care, LLC, is launching its new Prodigy ... , , , , ,The Prodigy Count-a-dose™ offers diabetics a device which can easily measure ...
... , ... Receive Major Addiction Certifications at No or Low Cost , ... (PRWEB) March 16, 2010 -- During economic times like ... human talent is left by the wayside as a result. For an addict these challenges ...
... Ten years later, many men weren,t bothered by treatment,s ... -- The balance between using enough radiation to ... effects at bay may not be as tricky as ... side effects appear to lessen with time. In fact, ...
... ... Latest Cosmetic Surgery Imaging System for the equivalent cost of a few dermal filler ... Toronto, ... virtual makeover tools, today announced the launch of VuMe, the company’s latest surgical imaging ...
... March 16 On Monday, March 22, 2010 ... will host a "Meet the Author!" webcast entitled "How Healthy Could ... Population Health Sciences and the Emeritus Vice Chancellor for Health Sciences ... Public Health, will discuss how states might expect their mortality rates ...
Cached Medicine News:Health News:Cloves are the best natural antioxidant 2Health News:Prodigy Re-Launches Syringe-Filling System for Blind and Low-Vision Diabetics 2Health News:Academy's Community Initiative Offers Qualifying Former Addicts Free Vocational Training 2Health News:Prostate Cancer Radiation Side Effects May Subside With Time 2Health News:ModiFace Launches VuMe in Southern Florida – the World's First Full-Featured Touch-Screen Cosmetic Surgery Imaging System 2Health News:ModiFace Launches VuMe in Southern Florida – the World's First Full-Featured Touch-Screen Cosmetic Surgery Imaging System 3Health News:Public Health Reports Will Host A 'Meet the Author!' Webcast Entitled 'How Healthy Could a State Be' 2
(Date:6/1/2015)... Middle Eastern MRI systems market is fast growing. MRI being ... of medicine like cardiology, neurology and orthopedics. It is replacing ... is as safer tool as it does not use ionizing ... into Open system, closed system and straight or upright system. ... it is preferred over that currently common closed type as ...
(Date:6/1/2015)... June 1, 2015  Diomics, an innovator in DNA ... , global financial executive, has joined Diomics, board of ... than 25 years of industry experience in broad global ... a managing director at Credit Suisse and JP Morgan, ... Witter. "Diomics is on the forefront of ...
(Date:6/1/2015)... May 29, 2015 Research and Markets ... the "Global Power Wheelchair Industry Report 2014" ... Global Power Wheelchair Industry Report 2014 is a ... of the power wheelchair industry. The ... including definitions, classifications, applications and industry chain structure. ...
Breaking Medicine Technology:Middle East MRI Market - Growth, Trends And Forecasts (2014 - 2019) 2Middle East MRI Market - Growth, Trends And Forecasts (2014 - 2019) 3Richard M. Weissman joins Diomics Board of Directors 2Global Power Wheelchair Industry Trends 2015-2020 2
... The Leukemia & Lymphoma,Society has awarded a $550,000 ... Wilmot Cancer Center at the University of Rochester Medical,Center. ... funding the first two years of the five-year program., ... will support,Dr. Friedberg,s work on a new targeted treatment ...
... Assay Submitted for FDA Clearance, SAN DIEGO, July ... and Company) (NYSE: BDX ), announced today the ... the rapid diagnosis,of patients with Clostridium difficile infection (CDI). ... simplicity and speed in one test,procedure. BD has also ...
Cached Medicine Technology:University of Rochester Researcher Named Millennium Pharmaceuticals Career Development Scholar of The Leukemia & Lymphoma Society 2BD Announces CE Marking of a New Molecular Test to Diagnose Patients with Clostridium difficile Infections 2BD Announces CE Marking of a New Molecular Test to Diagnose Patients with Clostridium difficile Infections 3