Navigation Links
Genetics May Boost Mexican-Americans' Risk for Alcoholism
Date:12/13/2007

Scientists zero in on a DNA cluster that may encourage the addiction

THURSDAY, Dec. 13 (HealthDay News) -- Mexican-Americans carrying what's known as a haplotype of a particular gene may be at increased risk of alcoholism, a new study finds.

Haplotypes are clusters of genetic polymorphisms or variations.

In the study,researchers at the University of Kansas Medical Center (UKMC)collected blood samples and clinical data from almost 700 Mexican-Americans (334 alcoholics and 365 non-alcoholics) living in the Los Angeles area.

They focused particularly on the CYP2E1 gene, and found that people "carrying haplotype H6, the combination of the four alleles [copies] -- 1C, c2, C and A2 -- appear to have increased susceptibility to developing alcoholism," corresponding author Yu-Jui Yvonne Wan, a professor of pharmacology and director of the Liver Center at UKMC, said in a prepared statement.

Wan also said that hapoltype H6 is associated with late-age onset of drinking, as well as heavy drinking. They also found that the H1, H2 and H3 haplotypes were associated with alcohol consumption and smoking.

More research is needed to examine the "functional significance" of the H6 haplotpye.

"Whether H6 changes enzyme activity or alcohol-induced enzyme activity needs to be examined," Wan said. "Although only 5 percent of Mexican alcoholics have the H6 haplotype, it is important to use the same approach to study other ethnic groups, particularly Asians, who have high frequency of both c2 and C alleles. Furthermore, since elevated CYP2E1 causes oxidative stress, polymorphisms of this gene might also have an impact on other disease processes such as cancer."

The study is published in the December issue of Alcoholism: Clinical and Experimental Research.

More information

The American Academy of Family Physicians has more about problem drinking.



-- Robert Preidt



SOURCE: Alcoholism: Clinical and Experimental Research, news release, Nov. 26, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Genetics Hold Promise, Challenges for Cancer Care
2. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
3. Salugen to Present Research on Generational Associations of Reward Deficiency Syndrome at XVth World Congress on Psychiatric Genetics
4. Obesity genetics
5. The genetics of MLL leukemogenesis
6. Vanda Pharmaceuticals to Present New Data on Iloperidone at the 2007 American Society of Human Genetics Annual Meeting
7. Clarient Names Michele Hibbard, Ph.D. Director of Genetics
8. Response Genetics Announces Presentation/Webcast at BIOCOM Investor Conference
9. Interleukin Genetics to Host Third Quarter 2007 Financial Results Conference Call November 7
10. Response Genetics to Announce Third Quarter 2007 Financial Results on Wednesday, November 14, 2007
11. Response Genetics Reports Third Quarter 2007 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017  South Korean-based healthcare product Development ... aide "cprCUBE" on Kickstarter. The device will educate the ... arrests with better efficiency compared to the dated and ... feedback on efficacy of the compression for a more ... a goal to raise $5,000. ...
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
(Date:9/27/2017)... their devotion to personalized service, SMP Pharmacy Solutions announces their ... South Florida Business Journal,s 50 Fastest-Growing Companies, and listed for ... specialty pharmacy has found its niche.  To that end, the ... by SFBJ as the 2017 Power Leader in Health Care. ... award in October, Bardisa said of the three achievements, "It,s ...
Breaking Medicine Technology: