Navigation Links
Genetics May Boost Mexican-Americans' Risk for Alcoholism
Date:12/13/2007

Scientists zero in on a DNA cluster that may encourage the addiction

THURSDAY, Dec. 13 (HealthDay News) -- Mexican-Americans carrying what's known as a haplotype of a particular gene may be at increased risk of alcoholism, a new study finds.

Haplotypes are clusters of genetic polymorphisms or variations.

In the study,researchers at the University of Kansas Medical Center (UKMC)collected blood samples and clinical data from almost 700 Mexican-Americans (334 alcoholics and 365 non-alcoholics) living in the Los Angeles area.

They focused particularly on the CYP2E1 gene, and found that people "carrying haplotype H6, the combination of the four alleles [copies] -- 1C, c2, C and A2 -- appear to have increased susceptibility to developing alcoholism," corresponding author Yu-Jui Yvonne Wan, a professor of pharmacology and director of the Liver Center at UKMC, said in a prepared statement.

Wan also said that hapoltype H6 is associated with late-age onset of drinking, as well as heavy drinking. They also found that the H1, H2 and H3 haplotypes were associated with alcohol consumption and smoking.

More research is needed to examine the "functional significance" of the H6 haplotpye.

"Whether H6 changes enzyme activity or alcohol-induced enzyme activity needs to be examined," Wan said. "Although only 5 percent of Mexican alcoholics have the H6 haplotype, it is important to use the same approach to study other ethnic groups, particularly Asians, who have high frequency of both c2 and C alleles. Furthermore, since elevated CYP2E1 causes oxidative stress, polymorphisms of this gene might also have an impact on other disease processes such as cancer."

The study is published in the December issue of Alcoholism: Clinical and Experimental Research.

More information

The American Academy of Family Physicians has more about problem drinking.



-- Robert Preidt



SOURCE: Alcoholism: Clinical and Experimental Research, news release, Nov. 26, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Genetics Hold Promise, Challenges for Cancer Care
2. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
3. Salugen to Present Research on Generational Associations of Reward Deficiency Syndrome at XVth World Congress on Psychiatric Genetics
4. Obesity genetics
5. The genetics of MLL leukemogenesis
6. Vanda Pharmaceuticals to Present New Data on Iloperidone at the 2007 American Society of Human Genetics Annual Meeting
7. Clarient Names Michele Hibbard, Ph.D. Director of Genetics
8. Response Genetics Announces Presentation/Webcast at BIOCOM Investor Conference
9. Interleukin Genetics to Host Third Quarter 2007 Financial Results Conference Call November 7
10. Response Genetics to Announce Third Quarter 2007 Financial Results on Wednesday, November 14, 2007
11. Response Genetics Reports Third Quarter 2007 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... Monica, CA (PRWEB) , ... May 03, 2016 , ... ... the highest quality medical providers to build the leading network of doctors and therapists ... Eric Nepomnaschy, D.C., founder of the distinguished Bay Chiropractic and Rehabilitation in ...
(Date:5/3/2016)... ... May 03, 2016 , ... SELEX (systematic evolution ... from a random library of sequences depending on their attraction for a target ... SELEX selection is commonly performed using filters, panning, or affinity chromatography separations. However, ...
(Date:5/3/2016)... FL (PRWEB) , ... May 03, 2016 , ... ... leading innovative specialty pharmacies, will be represented at the 2016 Asembia Specialty ... Vegas. The Asembia Summit is the largest U.S. health care conference for the ...
(Date:5/3/2016)... ... May 03, 2016 , ... Boston Children’s Hospital today announced its ... situations or practice tricky or rare procedures in an environment that looks and feels ... is also available to inventors and “hackers” to develop and test new devices or ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... announces Benefits Alliance Insurance Services as the latest addition to its elite stable ... comprised of Partners Wayne Blasman, David Styles, and Paul Vincent. The Firm is ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... April 29, 2016  In the next ten ... shift from systems dependent on CRTs monitors to those ... modality CRT Medical monitors and will automatically sync ... host of foreseeable benefits to this technological advancement, ... modalities have to be replaced in order to ...
(Date:4/29/2016)... 29, 2016 Glycotope GmbH, a ... announces the appointment of Dr. Alfredo Zurlo ... an oncologist with many years clinical experience and a ... His last role was at Mologen AG where he ... Board. Previously Dr. Zurlo held various positions at F ...
(Date:4/28/2016)... April 28, 2016 Research and ... Plastic Surgery Products Market 2016-2020" report to their ... , The global plastic surgery products market ... during the period 2016-2020. , ,The growing adoption of ... the growth of the market. Lasers are used to ...
Breaking Medicine Technology: