Navigation Links
Genetically modified tobacco plants produce antibodies to treat rabies
Date:2/1/2013

Bethesda, MDSmoking tobacco might be bad for your health, but a genetically altered version of the plant might provide a relatively inexpensive cure for the deadly rabies virus. In a new research report appearing in The FASEB Journal, scientists produced a monoclonal antibody in transgenic tobacco plants that was shown to neutralize the rabies virus. This new antibody works by preventing the virus from attaching to nerve endings around the bite site and keeps the virus from traveling to the brain.

"Rabies continues to kill many thousands of people throughout the developing world every year and can also affect international travelers," said Leonard Both, M.Sc., a researcher involved in the work from the Hotung Molecular Immunology Unit at St. George's, University of London, in the United Kingdom. "An untreated rabies infection is nearly 100 percent fatal and is usually seen as a death sentence. Producing an inexpensive antibody in transgenic plants opens the prospect of adequate rabies prevention for low-income families in developing countries."

To make this advance, Both and colleagues "humanized" the sequences for the antibody so people could tolerate it. Then, the antibody was produced using transgenic tobacco plants as an inexpensive production platform. The antibody was purified from the plant leaves and characterized with regards to its protein and sugar composition. The antibody was also shown to be active in neutralizing a broad panel of rabies viruses, and the exact antibody docking site on the viral envelope was identified using certain chimeric rabies viruses.

"Although treatable by antibodies if caught in time, rabies is bad news," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This is especially true for people in the developing world where manufacturing costs lead to treatment shortages. Being able to grow safe, humanized antibodies in genetically modified tobacco should reduce costs to make treatments more accessible, and save more lives."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Almost Nuts! a Wisconsin Company Innovates Healthy Snack Foods that are Not Genetically Modified
2. Genetically-engineered preclinical models predict pharmacodynamic response
3. More clues about why chimps and humans are genetically different
4. Some women may be genetically predisposed to smoking-related hot flashes
5. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
6. Head, Body Lice Are Genetically Very Similar
7. Studies assess genetics, modified treatment to improve outcomes, reduce toxicity
8. Regulatory science for public health: From functional food to modified-risk tobacco products
9. Researchers Identify Involuntary Tobacco Smoke Exposure in Boston Public Housing Authority Residents with Salivary Cotinine Testing from Salimetrics.
10. Treating tobacco addiction a duty, argue text editors
11. Smoking parents often expose children to tobacco smoke in their cars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... , ... Gevir, a New Zealand-based company that focuses on developing powder and ... to Amazon.com, the world’s largest online retailer. , The company was founded ... natural treatment for Shelley’s Multiple Sclerosis, which she’d been diagnosed with at 28 years ...
(Date:2/22/2017)... ... 2017 , ... South Bend’s Lunkerville, the award-winning TV series that catches real ... Water (HOW), a non-profit organization dedicated to helping military veterans relax, rehabilitate, and reintegrate ... traveling to Lake Denmark, New Jersey, to fish with war veteran Justin Vail from ...
(Date:2/22/2017)... Los Angeles, CA (PRWEB) , ... February 22, 2017 , ... ... with the recent addition of esteemed ophthalmologist, Dr. Steven H. Rauchman, practicing at ... are common in auto accidents, product liability, premise liability and other personal injury cases. ...
(Date:2/22/2017)... ... ... ANGLESTRONG , the new recovery management app with multiple innovative features ... and Google Play . Florida-based Sober Network, Inc., the premier provider of ... Angle to build ANGLESTRONG. The new recovery management app is a passion project for ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... communications company, launched a new media platform connecting healthcare technology professionals and other ... be followed by a quarterly publication starting on March 1, announced Michael J. ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 22, 2017 Research and Markets has ... Pipeline Review, 2016" report to their offering. ... Dermatological conditions ... and approximately one-third of the US population suffers from at ... majority of the dermatology market has remained saturated with established ...
(Date:2/22/2017)... and PUNE, India , February ... report published by Allied Market Research, titled, "Radiology Information System ... Opportunity Analysis and Industry Forecast, 2014-2022," the radiology information system ... projected to reach $941 million by 2022, growing at a ... information systems segment held over three-fifths share of the total ...
(Date:2/22/2017)... , February 22, 2017 ... the Dow Jones Industrial Average, and the S&P ... out of nine sectors ended Tuesday,s trading session ... sentiment, Stock-Callers.com assessed the following Medical Instruments & ... (NASDAQ: TNDM), C. R. Bard Inc. (NYSE: BCR), ...
Breaking Medicine Technology: