Navigation Links
Genetically-engineered preclinical models predict pharmacodynamic response
Date:9/19/2012

New cancer drugs must be thoroughly tested in preclinical models, often in mice, before they can be offered to cancer patients for the first time in phase I clinical trials. Key components of this process include pharmacokinetic and pharmacodynamic studies, which evaluate how the drug acts on a living organism. These studies measure the pharmacologic response and the duration and magnitude of response observed relative to the concentration of the drug at an active site in the organism.

A new comparison of four different methodologies for pharmacokinetic and pharmacodynamic testing of the anti-melanoma agent carboplatin, demonstrates that genetically-engineered mouse models provide tumor delivery of drug most comparable to the response seen in melanoma patients.

"These studies are critically important in the case of small-molecule cancer drugs, which often have systemic side effects and can be toxic at high concentrations," said Ned Sharpless, MD, Wellcome Distinguished Professor of Cancer Research and study co-author.

The study, led by Bill Zamboni, PharmD and PhD, Associate Professor of Pharmacotherapy and Experimental Therapeutics at the UNC Eshelman School of Pharmacy and a member of UNC Lineberger Comprehensive Cancer Center, and Ned Sharpless, MD, who is also Associate Director for Translational Research at UNC Lineberger.

The collaborative study, which appears in The Oncologist, brought together a set of unique resources available at UNC to determine which preclinical models best predict delivery of carboplatin to melanoma tumors in patients. "We have a unique opportunity to evaluate an important factor in the treatment of solid tumors because of the outstanding collaborative nature and novel resources at UNC", said Zamboni.

"We have used a pharmacokinetics testing method called microdialysis, which uses a tiny probe to take samples that measure serial drug concentrations in a tumor over time," he ad
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina Health Care
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Preclinical data support ongoing clinical trials testing IDO inhibitors as a treatment for cancer
2. TRPM7 protein key to breast cancer metastasis in animal models
3. Heterogeneous ER+ breast cancer models allow more accurate drug testing
4. Internists express support for new payment and delivery models as basis for replacing SGR
5. Super Models Line Up to Walk The Catwalk and Celebrate Vogue's Fashion Night Out in LA
6. Simple test to predict if pregnant women will give birth prematurely
7. Moffitt cancer center researchers find novel predictor for MDS progression risk
8. Elevated Antibody Levels May Predict Rheumatoid Arthritis Risk
9. Study uncovers simple way of predicting severe pain following breast cancer surgery
10. Artery Stiffness May Predict High Blood Pressure
11. Pretreatment PET/CT imaging of lymph nodes predicts recurrence in breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014 Computer Resources of America, ... based in New York City, has been awarded ... to transform, manage, and support the IT environment ... a leading provider of innovative services that enable ... The contract will cover the four NY-metro ...
(Date:9/30/2014)... Albany, IN (PRWEB) September 30, 2014 ... Dr. Ron Receveur encourages all persons who have received ... disease in a recent blog post. , The post, ... those with dental implants that if they don’t brush ... the same way people lose their natural teeth: the ...
(Date:9/30/2014)... Ontario, Canada (PRWEB) September 30, 2014 ... diagnostic imaging services based in San Juan, Puerto ... automate their workflows. , Nivia Souffront, site ... to their facility. “We are excited to bring ... to provide better patient care and physician satisfaction ...
(Date:9/30/2014)... September 30, 2014 3M has added four ... high bond tapes. 3M 5906 , 3M 5907 ... are conformable VHBs which help create the strongest bond possible ... are used for bonding to difficult surfaces such as paints, ... 5906, 5907, 5908, and 5905 are designed specifically for electronic ...
(Date:9/30/2014)... FL (PRWEB) September 30, 2014 Doctors often ... received abnormal mammogram results. Most breast ultrasounds are done ... Center for Diagnostic Imaging in Miami . The Center ... as an alternative to MRI. Most patients find ultrasounds ... open space and do not have to remain perfectly still. ...
Breaking Medicine News(10 mins):Health News:CRA Awarded Managed Services Contract for Large NYC Nonprofit 2Health News:All on Four Dental Implants Dentist Writes Blog on Preventing Gum Disease 2Health News:All on Four Dental Implants Dentist Writes Blog on Preventing Gum Disease 3Health News:Signet Puerto Rico Leverages PowerServer RIS/PACS/PM™ to Improve Patient Care, Cut Costs 2Health News:3M Releases New VHB™ Thin Foam Tapes as the Ultimate Electronics Bonding Solution 2Health News:3M Releases New VHB™ Thin Foam Tapes as the Ultimate Electronics Bonding Solution 3Health News:Breast Ultrasounds Are a Comfortable and Convenient Option for Patients and Referring Doctors 2
... Hospital surgeons found that a carefully-selected surgical care check ... nearly 50 percent. Smoking cessation at least ... to skin closure, and using clippers over razors to shave ... reduced infection rates, according to the study published in the ...
... TUESDAY, Oct. 25 (HealthDay News) -- The most widely used ... percent effective in healthy adults, new research indicates. That ... about 90 percent of flu shots in this country, according ... The Lancet Infectious Diseases . The less common live ...
... just for making freckles and tans. Melanocytes absorb ultraviolet light, ... They also are the cells that go haywire in melanoma, ... albinism. Naturally, researchers would love to study melanocytes in ... skin don,t grow very well in the lab. Now, researchers ...
... the more than 10,000 substances that may be added ... a trade association without review by the U.S. Food ... by the Pew Health Group. , The report, published ... Food Science and Food Safety , illustrates potential problems ...
... Stanford, CA -- Calling for more rapid innovation in ... program of the Thiel Foundation, Breakout Labs. Speaking ... Association of Stanford Entrepreneurial Students, Thiel announced that Breakout ... way early-stage science and technology research is funded by ...
... in the Department of Radiation Oncology at Thomas Jefferson ... named an "Educator of the Year" by the Association ... the annual Educator of the Year Award to recognize ... from all radiation oncology programs were given the opportunity ...
Cached Medicine News:Health News:Thomas Jefferson University Hospital cuts Whipple procedure wound infections in half with new measures 2Health News:Flu Vaccine Isn't Foolproof 2Health News:Flu Vaccine Isn't Foolproof 3Health News:Lab-made skin cells will aid transplantation, cancer, drug discovery research 2Health News:Food chemical regulations rely heavily on industry self-policing and lack transparency 2Health News:Peter Thiel announces Breakout Labs to energize innovation 2Health News:Jefferson physician named an 'Educator of the Year' by the Assocociation of Residents in Radiation Oncology 2
(Date:9/29/2014)... et SAN DIEGO , ... Ltd. (ci-après désignée Daiichi Sankyo) (TSE : 4568) et ... la conclusion d,un accord de fusion définitif en ... totalité des actions ordinaires en circulation d,Ambit Biosciences ... le biais d,une offre publique d,achat qui sera ...
(Date:9/29/2014)... Pharmacists have an important role in ... good clinical trials practices. The Hematology/Oncology Pharmacy Association ... Practice Standards, the first of its kind that ... pharmacists and institutions that conduct clinical trials. The ... the critical role of the pharmacist in the ...
(Date:9/29/2014)... -- Bob Pack, who lost his two young children to ... Association to immediately cease airing a television ad from ... News called "shamelessly deceptive" and of which the LA ... about the measure is wrong." The ... doctors check California,s existing statewide ...
Breaking Medicine Technology:Daiichi Sankyo va acquérir Ambit Biosciences 2Daiichi Sankyo va acquérir Ambit Biosciences 3Daiichi Sankyo va acquérir Ambit Biosciences 4Daiichi Sankyo va acquérir Ambit Biosciences 5Daiichi Sankyo va acquérir Ambit Biosciences 6Daiichi Sankyo va acquérir Ambit Biosciences 7Daiichi Sankyo va acquérir Ambit Biosciences 8Daiichi Sankyo va acquérir Ambit Biosciences 9HOPA Introduces First Investigational Drug Service Best Practice Standards For Institutions And Infusion Clinics 2HOPA Introduces First Investigational Drug Service Best Practice Standards For Institutions And Infusion Clinics 3Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 2Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 3Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 4Father Calls On CA Medical Assn To Pull TV Ad Called "Jaw-Droppingly Deceptive" and "Baloney" By LA Times & "Shamelessly Deceptive" By San Jose Mercury News, Says Consumer Watchdog Campaign 5
... Cumberland Pharmaceuticals Inc.(Nasdaq: CPIX ) today announced ... review of the supplemental new drug application (sNDA) for the ... non-acetaminophen acute liver failure. The review has been extended by ... Act (PDUFA) goal date in December 2010. ...
... Aug. 20 Environmental Tectonics Corporation,s (OTC Bulletin ... ,Company") Biomedical Systems, a worldwide leader in the ... confirmed that it has received FDA 510-k clearance ... for "Operating System for Control And Recording." This ...
Cached Medicine Technology:Cumberland Pharmaceuticals Announces Extension of FDA Review of Acetadote® Supplemental New Drug Application 2Cumberland Pharmaceuticals Announces Extension of FDA Review of Acetadote® Supplemental New Drug Application 3ETC Biomedical Systems Offers New FDA Approved Hyperbaric Oxygen Therapy (HBOT) Medical Device 2ETC Biomedical Systems Offers New FDA Approved Hyperbaric Oxygen Therapy (HBOT) Medical Device 3ETC Biomedical Systems Offers New FDA Approved Hyperbaric Oxygen Therapy (HBOT) Medical Device 4
... Micro Anchor is the smallest, strongest ... flexibility in placement into even the ... with 3-0 or 4-0 ETHIBOND EXCEL ... or cutting swaged needles. The kit ...
... a threaded titanium anchor, specifically ... The anchor features wide threads ... optimize bone purchase, as well ... prevent suture binding. Fastin RC ...
The GII titanium anchor is the "Gold Standard" for soft tissue reattachment to bone. The GII's small size, high pull-out strength and wide range of clinical applications make it the anchor of choice ...
... Proxis features 'proximal protection' -- providing ... removal, even in vessels with side branches. ... to use. It does not require the ... removal of embolic debris. ,Proxis is ...
Medicine Products: