Navigation Links
Genetic variations raise lung cancer risk for smokers and ex-smokers
Date:4/2/2008

ry by a single DNA chemical building block or nucleotide. Individuals who have ever smoked and who have one or two copies of either of these SNPs have increased risks ranging from 28 percent to 81 percent of developing lung cancer, the researchers found.

The team's findings might also provide support for a growing body of evidence suggesting that nicotine, long known as the prime addictive compound in cigarettes, might also play a direct causative role in the development of lung cancer.

There are five genes in the area of chromosome 15 where the two risk-raising SNPs were identified, Amos explained. Of those, three are nicotine acetylcholine receptor genes that encode proteins that serve as docking sites to which nicotine can bind.

"Once bound, these receptors set in motion a cascade of signals. Nicotine is known to activate cell proliferation, new blood vessel development and growth factors while upregulating several signaling pathways. If these are indeed causal genes, that will be of great interest," Amos said.

Another potential causative gene in the area is one that encodes a component of the proteasome, which degrades other proteins. The function of the fifth gene has yet to be identified.

Further studies with additional SNPs in African-American populations who show different SNP patterns may help to define which of these five genes causes lung cancer. Collaborations with both M. D. Anderson's Lung SPORE and the Kleberg Center for Molecular Markers will evaluate whether these SNPs influence expression of any of these five genes in lung cancers and normal lung tissue, Amos said.

Lung cancer causes more deaths than any other cancer, killing more than 160,000 Americans annually and millions worldwide. Non-small cell lung cancer makes up 80 percent of all lung cancer cases.

Amos and senior co-author Margaret Spitz, M.D., chair of M. D. Anderson's Department of Epidemiology, conceived the study, which
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. Genetic predisposition increases childhood asthma risk
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Test Spots Genetic Damage Done by Smoking
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
7. Genetics Hold Promise, Challenges for Cancer Care
8. Researchers genetically engineer micro-organisms into tiny factories
9. Study Questions Genetic Screening for Treatable Diseases
10. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
11. Genetic variation affects smoking cessation treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic variations raise lung cancer risk for smokers and ex-smokers
(Date:10/22/2014)... October 22, 2014 For Dr. Iris Hunter, ... money; it’s an extension of her life’s mission. Her extensive ... as the owner of FirstLight HomeCare, make it clear that ... to me that my work makes a difference in the ... entrepreneurial spirit, so after much research, I felt ready to ...
(Date:10/22/2014)... California (PRWEB) October 22, 2014 Hay House ... Move Beyond Addiction and Upgrade Your Life (Paperback; $10.82) written ... of Yoga & Recovery. This book is meant to ... in a life of recovery. , Recovery 2.0 is ... 12 Steps; Recovery 2.0 is a guide for what comes ...
(Date:10/22/2014)... Weight Your Body’s Way , In a world where a ... certainly can be difficult to choose the right weight loss ... doing it the healthy way? Set aside the fads and ... exercise regularly, and choose foods with the most nutritional benefits. ... to exercise more and eat less. Despite the number of ...
(Date:10/22/2014)... Steven Reinberg HealthDay Reporter , ... add weight and length may be showing a genetic propensity ... adults, certain genes have been linked to increased body fat, ... fat and lean muscle, the researchers said. At 1 ... By ages 2 and 3, however, these genes were linked ...
(Date:10/22/2014)... Oct. 21, 2014 (HealthDay News) -- Measures taken by ... in Ebola-ravaged Liberia may have limited the spread of ... report. The Firestone Natural Rubber Co. provides health ... residents of nearby densely populated communities. Between Aug. ... suspected Ebola cases among those 80,000 people. That incidence ...
Breaking Medicine News(10 mins):Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2
... refugees in unofficial camps are living in slum conditions redolent ... the Journal of Epidemiology and Community Health. , The research ... Gaza Displacement Centre in Beirut, Lebanon in May 2003. , ... lived in, access to outside air, the presence of mould ...
... release is also available in Spanish . ... expert on nutrition, studied the health benefits of the ... studies on the benefits of olive oil have been ... and Greece (the main olive-oil-producing countries), the incidence of ...
... increase , , THURSDAY, Jan. 17 (HealthDay News) -- The ... three decades, according to a new report released Thursday. ... Jones, senior research associate at the Guttmacher Institute, a ... will be published in the March issue of the ...
... Jan. 17 Cardiva Medical, Inc., a,privately held ... System is pleased to announce the addition of ... Cardiva as Vice President,of Finance and Chief Financial ... Business Development and Marketing., "We are very ...
... Pa., Jan. 16 With Gov. Ed,Rendell refusing to ... Exec. Dir. of the more than 65,000-member Council 13,AFSCME, ... is,mobilizing retiree members to fight back. AFSCME recently sent ... call the governor and to send,provided postcards urging him ...
... SEATTLE, Jan. 16 Hagens Berman Sobol Shapiro has ... ) and,Schering-Plough (NYSE: SGP ), manufacturers of Zetia ... Merck and Schering-Plough,violated state consumer protection laws arising from ... is the combination of Zetia and Zocor, a statin ...
Cached Medicine News:Health News:Palestinian refugees living in 'slum conditions' 2Health News:Consuming extra virgin olive oil helps to combat degenerative diseases such as cancer 2Health News:U.S. Abortion Rate Falls to Lowest Level in Decades 2Health News:U.S. Abortion Rate Falls to Lowest Level in Decades 3Health News:Cardiva Medical, Inc. Appoints Two New Officers: Malcolm Farnsworth as Vice President of Finance and Chief Financial Officer and Tara Zerby as Vice President of Business Development and Marketing 2Health News:AFSCME to Gov. Rendell: Don't Cut Health Benefits for State Retirees! 2Health News:Hagens Berman Sobol Shapiro Announces Investigation Into Marketing of Vytorin and Zetia 2Health News:Hagens Berman Sobol Shapiro Announces Investigation Into Marketing of Vytorin and Zetia 3
(Date:10/22/2014)... , Oct. 22, 2014   Foundation ... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ) ... genomic profiling to biopharmaceutical companies conducting clinical trials in ... the terms of the collaboration, Foundation Medicine will license ... Foundation Medicine,s FoundationOne® assay at the WuXi Genome Center ...
(Date:10/20/2014)... 2014  Luoxis Diagnostics, Inc., a subsidiary of ... that its academic collaborators will present several peer-reviewed ... its novel RedoxSYS Diagnostic System, a first-in-class platform ... in response to injury or illness.  A poster ... clinical marker will be presented by Christopher ...
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., a ... antibodies, today announced the appointment of Marco ... Londei will lead the preclinical and clinical development ... "We are pleased to welcome Dr. Londei to ... , President and Chief Executive Officer of AnaptysBio. ...
Breaking Medicine Technology:Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 3Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 4Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 5Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 2Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 3Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 4Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 5AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2
... Workers Ensure Emergency Deliveries are Transported , ... chapter of the American Red Cross are hard at work ... endure that could potentially put Philadelphia,s blood supply at risk. ... up a picket line yesterday when their issues were ignored ...
... , , SALT LAKE CITY, Dec. 4 ... signed a sole-source vendor agreement to provide therapy equipment and ... in Tennessee and Georgia. , "We are pleased to ... Larry K. Beardall, executive vice president of sales and marketing ...
Cached Medicine Technology:Striking Red Cross Workers Raise Public Awareness of Unsafe Working Conditions 2
... neurodiagnostic for basic and advanced ... a large 12.1" XGA (1024 ... and the latest in technology ... speed, advanced NCS capabilities, advanced ...
... is a non-invasive and painless method of ... Cadwell Laboratories manufactures two magnetic stimulation devices, ... Stimulator (HSMS). The Hight Speed ... rates up to 25 Hz at full ...
... illuminated hand-held potential vision tester measures retinal ... glaucoma. Potential vision testing requires two ... or RAM (formerly known as the Illuminated ... (clip with a pinhole disc and hinged ...
... MOBEE headboxes are ... Xltek's line of portable ... with a robust new ... latest software, XLTEK's standard ...
Medicine Products: