Navigation Links
Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients
Date:12/7/2009

HOUSTON - Eighteen single-point genetic variations indicate risk of recurrence for early-stage head and neck cancer patients and their likelihood of developing a second type of cancer, researchers at The University of Texas M. D. Anderson Cancer Center reported at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference.

The team examined 241 single nucleotide polymorphisms - variations of a single DNA building block in a gene - in eight genes involved in the creation of micro RNA (miRNA), small bits of RNA that regulate genes, and 130 miRNA binding sites on host genes where miRNAs exert their effects on regulating gene expression.

"We focus on miRNA pathways because these small molecules regulate between one third and half of genes," said senior author Xifeng Wu, M.D., Ph.D., professor in M. D. Anderson's Department of Epidemiology in the Division of Cancer Prevention and Population Sciences.

"Genetic variations in miRNA biogenesis genes and miRNA binding sites have been associated with the risk of having multiple solid tumors, so we hypothesized that these variations might be associated with the risk of recurrence or secondary primary tumors in these patients," Wu said.

About 10 percent of patients have a recurrence, and 15-25 percent go on to develop secondary primary tumors.

The team conducted a case-control study of 150 patients with recurrence or a second cancer and 300 patients without either. They found eighteen SNPs to be associated with recurrence/secondary cancer risk, including eleven SNPs in three miRNA biogenesis genes and seven in miRNA binding sites. Eight of the significant SNPs were in RNASEN gene, one of which was associated with a 72 percent increase in risk.

Compared to patients with fewer than four unfavorable genotypes, patients with five to nine unfavorable genotypes have a 2.4-fold increased risk and those with more than ten a 7.7-fold rise in risk.

Additional analysis of gene-gene interaction characterized the study patients into risk groups. The low-risk group had an event-free median survival time of more than 93 months. The highest-risk group had five times the risk of the low-risk group, and an event-free median survival of 35.9 months.

"Our results suggest that genetic variations in the miRNA biogenesis pathway and miRNA binding sites may be used to predict the risk of recurrence or secondary primary tumor in head and neck cancer patients," said first author Xiaofan Zhang, Ph.D., a postdoctoral fellow in epidemiology.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. Genetic predisposition increases childhood asthma risk
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Test Spots Genetic Damage Done by Smoking
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
7. Genetics Hold Promise, Challenges for Cancer Care
8. Researchers genetically engineer micro-organisms into tiny factories
9. Study Questions Genetic Screening for Treatable Diseases
10. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
11. Genetic variation affects smoking cessation treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients
(Date:12/8/2016)... ... December 08, 2016 , ... ... surgery as possible. With this in mind, SIGVARIS has created a new line ... clot) during bed rest and provide the benefits of graduated compression when transitioning ...
(Date:12/8/2016)... ... December 08, 2016 , ... Vida Health, the digital ... B led by Canvas Ventures . Other investors include Nokia Growth Partners (NGP) ... platform to serve more consumers who are managing chronic conditions or simply ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... planning services from offices headquartered in Hamilton County, is embarking on a charity ... LuvFurMutts specializes in finding new homes for orphaned or neglected senior dogs in ...
(Date:12/8/2016)... ... December 08, 2016 , ... Peter Zipp ... in and around the greater Phoenix metropolitan region, is announcing a charity event ... mission of the Homeless Youth Connection is to promote community awareness of the ...
(Date:12/8/2016)... Bay St. Louis, MS (PRWEB) , ... December 08, 2016 , ... ... with offices that serve commercial and residential clients in and around the Hancock County ... community support for the Hancock County Food Pantry. , The Hancock County Food Pantry ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... -- Boehringer Ingelheim announced today that it has been recognized ... the ninth time that the company received a perfect ... to Work for LGBT Equality. Administered by the Human ... report on corporate policies and practices related to workplace ... "We are committed to creating an ...
(Date:12/8/2016)... December 8, 2016 According ... Market by Product (Actual Sugars, Sugar Alcohols, Artificial ... Diluent, Tonicity Agents), Formulation (Oral, Topical, Parenteral) - ... market has witnessed healthy growth during the last ... CAGR of 4.3% between 2016 and 2021 to ...
(Date:12/8/2016)... According to a new market research report "Wearable Medical Devices ... End Use (Sports, Fitness, RPM), Type (Smart watch, Patch), Distribution Channel (Pharmacy, ... terms of value, is projected to reach 12.14 Billion by 2021 from ... forecast period. Continue Reading ... ...
Breaking Medicine Technology: