Navigation Links
Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients
Date:12/7/2009

HOUSTON - Eighteen single-point genetic variations indicate risk of recurrence for early-stage head and neck cancer patients and their likelihood of developing a second type of cancer, researchers at The University of Texas M. D. Anderson Cancer Center reported at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference.

The team examined 241 single nucleotide polymorphisms - variations of a single DNA building block in a gene - in eight genes involved in the creation of micro RNA (miRNA), small bits of RNA that regulate genes, and 130 miRNA binding sites on host genes where miRNAs exert their effects on regulating gene expression.

"We focus on miRNA pathways because these small molecules regulate between one third and half of genes," said senior author Xifeng Wu, M.D., Ph.D., professor in M. D. Anderson's Department of Epidemiology in the Division of Cancer Prevention and Population Sciences.

"Genetic variations in miRNA biogenesis genes and miRNA binding sites have been associated with the risk of having multiple solid tumors, so we hypothesized that these variations might be associated with the risk of recurrence or secondary primary tumors in these patients," Wu said.

About 10 percent of patients have a recurrence, and 15-25 percent go on to develop secondary primary tumors.

The team conducted a case-control study of 150 patients with recurrence or a second cancer and 300 patients without either. They found eighteen SNPs to be associated with recurrence/secondary cancer risk, including eleven SNPs in three miRNA biogenesis genes and seven in miRNA binding sites. Eight of the significant SNPs were in RNASEN gene, one of which was associated with a 72 percent increase in risk.

Compared to patients with fewer than four unfavorable genotypes, patients with five to nine unfavorable genotypes have a 2.4-fold increased risk and those with more than ten a 7.7-fold rise
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. Genetic predisposition increases childhood asthma risk
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Test Spots Genetic Damage Done by Smoking
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
7. Genetics Hold Promise, Challenges for Cancer Care
8. Researchers genetically engineer micro-organisms into tiny factories
9. Study Questions Genetic Screening for Treatable Diseases
10. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
11. Genetic variation affects smoking cessation treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients
(Date:7/6/2015)... ... July 06, 2015 , ... Acara Partners, ... announces the return of its complimentary educational webinar series for the ... leaders creates success for their clients through targeted marketing, sales, digital communications, branding ...
(Date:7/6/2015)... Columbus, OH (PRWEB) , ... July 06, 2015 ... ... obtaining the proper reimbursement for radiology services and ADVOCATE is leading the transition. ... leveraging their coding expertise with their Top 10 Tips for ICD-10. The ten ...
(Date:7/6/2015)... ... July 06, 2015 , ... Health care systems and genomics projects have generated ... to access and use this “Big Data” to improve health and cut costs is ... of the Mount Sinai Health System in New York City. Physicians will have these ...
(Date:7/6/2015)... ... 06, 2015 , ... The School of Public Health at ... three-year effort to reduce rates of diabetes and cardiovascular disease in African-American neighborhoods ... Morehouse School of Medicine’s Prevention Research Center and the Satcher Health Leadership Institute ...
(Date:7/6/2015)... ... 2015 , ... Diabetes affects many of us and the Glycemic Load and ... the majority of which are Type 2. However, eight million do not know they ... have prediabetes (abnormally high blood sugar levels). Without reductions in blood sugar levels and ...
Breaking Medicine News(10 mins):Health News:Acara Partners Announces Complimentary Educational Webinar Series for Cosmetic Medical Practices and MedSpas 2Health News:Acara Partners Announces Complimentary Educational Webinar Series for Cosmetic Medical Practices and MedSpas 3Health News:ADVOCATE Takes the Lead to Ensure ICD-10 Success: “Top 10 Tips for ICD-10” 2Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 2Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 3Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 4Health News:Mount Sinai CEO Kenneth L. Davis, MD: Our Ability to Access Information in Real Time to Prevent Disease is Drawing Closer 5Health News:Georgia State, Morehouse Partner To Tackle Diabetes, Heart Disease In Atlanta’s Minority Communities 2Health News:115 Million in the U.S. could beat diabetes with the help of a new app 2
... variants, cigarette smoking greatly increases the risk that a ... out called an aneurysm which could be ... the American Stroke Association,s International Stroke Conference 2010. Researchers ... Aneurysm (FIA) project, a multinational collaboration funded by the ...
... ... ... ... ...
... ... ... , ... , , , ...
... 30 percent reduction in lost tissue, study found , FRIDAY, ... blood to the heart by repeatedly inflating a blood pressure ... a heart attack, a new Danish study shows. , In ... for treatment of severe heart attacks, the amount of heart ...
... , ... ... ... ...
... ... trial information is available at IQMesothelioma.com for mesothelioma patients and asbestos exposure victims who ... , ... 26, 2010 -- IQ Mesothelioma is pleased to provide comprehensive resources for mesothelioma patients ...
Cached Medicine News:Health News:Smoking significantly increases risk of aneurysm in people with certain genes 2Health News:Smoking significantly increases risk of aneurysm in people with certain genes 3Health News:Dairy Industry Raises a Glass of Milk to Let's Move! Campaign 2Health News:Dairy Industry Raises a Glass of Milk to Let's Move! Campaign 3Health News:Dairy Industry Raises a Glass of Milk to Let's Move! Campaign 4Health News:Dairy Industry Raises a Glass of Milk to Let's Move! Campaign 5Health News:Clitoraid Announces New Round of Clitoral Repair Surgeries in U.S. for FGM Victims 2Health News:Clitoraid Announces New Round of Clitoral Repair Surgeries in U.S. for FGM Victims 3Health News:Cutting Off Blood Flow to Heart Cuts Damage During Heart Attack 2Health News:Cutting Off Blood Flow to Heart Cuts Damage During Heart Attack 3Health News:Cardiologists Comment on Aspirin Versus Resveratrol 2Health News:Cardiologists Comment on Aspirin Versus Resveratrol 3Health News:Cardiologists Comment on Aspirin Versus Resveratrol 4Health News:Cardiologists Comment on Aspirin Versus Resveratrol 5Health News:Cardiologists Comment on Aspirin Versus Resveratrol 6Health News:Mesothelioma Clinical Trials List Offered by IQ Mesothelioma: Search Current Mesothelioma Treatment Options 2Health News:Mesothelioma Clinical Trials List Offered by IQ Mesothelioma: Search Current Mesothelioma Treatment Options 3
(Date:7/6/2015)... 6, 2015 Moerae Matrix, a clinical ... that target inflammation and fibrosis, today announced the ... as Chief Medical Officer. Dr. ... and programs, which include a pipeline of therapies ... conditions.  Bill is an accomplished strategist and scientist ...
(Date:7/6/2015)... DUBLIN and SOUTH SAN FRANCISCO, ... plc (NYSE: AGN ), a leading global pharmaceutical ... on developing novel treatments for dry eye disease, today ... which Allergan will acquire Oculeve in an all-cash transaction. ... Oculeve for a $125 million upfront payment and commercialization ...
(Date:7/5/2015)... Nihon University is pleased to announce ... Collaboration "Medicine Definitely Jumps Up with 8K" will ... Tokyo, Japan . Many experts on ... present their achievements and future prospects on progress ... with 8K technology. (Documentation: http://prw.kyodonews.jp/prwfile/release/M000079/201507031722/_prw_OA1fl_Xy4Q5W4x.pdf ...
Breaking Medicine Technology:Moerae Matrix, Inc. (Moerae) Appoints Bill Bradford, M.D., PhD, as Chief Medical Officer 2Allergan to Acquire Oculeve Dry Eye Disease Development Programs 2Allergan to Acquire Oculeve Dry Eye Disease Development Programs 3Allergan to Acquire Oculeve Dry Eye Disease Development Programs 4Nihon University to Host International Symposium on Medical-Engineering Collaboration 2Nihon University to Host International Symposium on Medical-Engineering Collaboration 3
... CHENGDU, China , June 28 ... biopharmaceutical company that specializes,in patented biopharmaceutical, modernized traditional Chinese ... product portfolio at,the 45th 2010 National New Special Drugs ... 8th , till July 10th . Tianyin,s portfolio ...
... SAN DIEGO , June 28 ADVENTRX Pharmaceuticals, ... added to the Russell Microcap® Index on June 25, 2010 , ... , , ... available only to companies listed on a national exchange, is consistent with ...
Cached Medicine Technology:Tianyin Promotes its Flagship Product Portfolio at the 45th 2010 National New Special Drugs Trade Fair in July at Beijing 2Tianyin Promotes its Flagship Product Portfolio at the 45th 2010 National New Special Drugs Trade Fair in July at Beijing 3ADVENTRX Added to Russell Microcap Index 2
... The pharmaceutical subset of the ... 21 of the Code of ... and final rules published in ... updated regularly as released by ...
... measuring principle - Pupil Zone Imaging Method ... offers high accuracy and reliability in refraction ... measurement (3.3 mm) using a mire ring, ... 4 points, both of which offer reliable ...
The combination of new measuring principle - Pupil Zone Imaging Method - and unique technology - SLD - offers high accuracy and reliability in refraction measurement....
... The ISI Free-Standing upper extremity table ... and in-office procedures. This table features ... and an extra-durable, hour-glass shaped Lexan ... stable -- this table is our ...
Medicine Products: