Navigation Links
Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients
Date:12/7/2009

HOUSTON - Eighteen single-point genetic variations indicate risk of recurrence for early-stage head and neck cancer patients and their likelihood of developing a second type of cancer, researchers at The University of Texas M. D. Anderson Cancer Center reported at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference.

The team examined 241 single nucleotide polymorphisms - variations of a single DNA building block in a gene - in eight genes involved in the creation of micro RNA (miRNA), small bits of RNA that regulate genes, and 130 miRNA binding sites on host genes where miRNAs exert their effects on regulating gene expression.

"We focus on miRNA pathways because these small molecules regulate between one third and half of genes," said senior author Xifeng Wu, M.D., Ph.D., professor in M. D. Anderson's Department of Epidemiology in the Division of Cancer Prevention and Population Sciences.

"Genetic variations in miRNA biogenesis genes and miRNA binding sites have been associated with the risk of having multiple solid tumors, so we hypothesized that these variations might be associated with the risk of recurrence or secondary primary tumors in these patients," Wu said.

About 10 percent of patients have a recurrence, and 15-25 percent go on to develop secondary primary tumors.

The team conducted a case-control study of 150 patients with recurrence or a second cancer and 300 patients without either. They found eighteen SNPs to be associated with recurrence/secondary cancer risk, including eleven SNPs in three miRNA biogenesis genes and seven in miRNA binding sites. Eight of the significant SNPs were in RNASEN gene, one of which was associated with a 72 percent increase in risk.

Compared to patients with fewer than four unfavorable genotypes, patients with five to nine unfavorable genotypes have a 2.4-fold increased risk and those with more than ten a 7.7-fold rise in risk.

Additional analysis of gene-gene interaction characterized the study patients into risk groups. The low-risk group had an event-free median survival time of more than 93 months. The highest-risk group had five times the risk of the low-risk group, and an event-free median survival of 35.9 months.

"Our results suggest that genetic variations in the miRNA biogenesis pathway and miRNA binding sites may be used to predict the risk of recurrence or secondary primary tumor in head and neck cancer patients," said first author Xiaofan Zhang, Ph.D., a postdoctoral fellow in epidemiology.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Many Parents Share Genetic Test Findings With Kids
2. Genetic predisposition increases childhood asthma risk
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Test Spots Genetic Damage Done by Smoking
5. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
6. Scientists highlight benefits of genetic research in sport, but warn of ethical concerns
7. Genetics Hold Promise, Challenges for Cancer Care
8. Researchers genetically engineer micro-organisms into tiny factories
9. Study Questions Genetic Screening for Treatable Diseases
10. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits
11. Genetic variation affects smoking cessation treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic variations indicate risk of recurrence, secondary cancer among head and neck cancer patients
(Date:7/21/2017)... ... July 21, 2017 , ... ... selected to renovate and improve the Ramsey County Medical Examiners Facility located in ... Hospital, the $2.5 million project is scheduled to start in late 2017/early 2018. ...
(Date:7/21/2017)... ... 21, 2017 , ... Bernard R. Bach, Jr., MD, orthopaedic surgeon at Rush ... Society of Sports Medicine (AOSSM) , received the 2017 Robert E. Leach Sports Medicine ... Canada. This prestigious award is given annually to honor those who have made a ...
(Date:7/21/2017)... (PRWEB) , ... July 21, 2017 , ... ... 4th-year medical students improve their chances of acceptance to a residency in a ... who have earned degrees outside the U.S. , According to data released by ...
(Date:7/21/2017)... TORONTO, ONTARIO, CANADA (PRWEB) , ... July 21, ... ... with over 80% follow-up at 10 years, researchers from the Multicenter Orthopaedics Outcome ... knee-related quality of life a decade after surgery, though activity levels decline over ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ChenMed ... MD, has joined JenCare Senior Medical Center as Richmond Chief Medical Officer. ... School of Medicine, and Associate Chief Medical Officer of Ambulatory Services for the UVA ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... 2017  New York City-based market research firm Kalorama Information ... aware of.  From new products to new costs, to the ... recently completed study, Potential Pipeline Disruptors . ... 1.  Age-Driven Growth - True Impact Moment Arriving ... the impact the growing population and, to a more extreme ...
(Date:7/11/2017)... , July 11, 2017  The global market ... revenues of approximately $394.1 million in 2016.  Although in ... of solid growth, in particular as a result of ... practice, and the recent introduction of a significant number ... for less-invasive testing of tumor biomarkers to guide treatment ...
(Date:7/10/2017)... Md. , July 10, 2017 The ... non-animal test methods, is the recipient of a VITROCELL® ... the PETA International Science Consortium. The device, which is ... used to expose human lung cells to airborne test ... IIVS will use the VITROCELL® system for testing combustible ...
Breaking Medicine Technology: