Navigation Links
Genetic variation linked to longer telomeres and lower risk of bladder cancer

ORLANDO, Fla. Using new genetic information, scientists have linked a commonly found human genetic variant with both longer telomeres and reduced risk of bladder cancer, according to findings presented at the AACR 102nd Annual Meeting 2011, held April 2-6, and simultaneously published in Cancer Prevention Research, a journal of the American Association for Cancer Research.

Jian Gu, Ph.D., assistant professor of epidemiology at The University of Texas MD Anderson Cancer Center, said the single-nucleotide polymorphism (SNP) rs398652 on 14q21 was linked to both longer telomeres and a 19 percent reduction in the risk of bladder cancer.

"This genetic locus is a determinant of both telomere length and bladder cancer risk, and long telomeres partially mediates the protective effect of the variant on bladder cancer," said Gu.

Gu and colleagues analyzed 300,000 SNPs in 459 healthy participants and found 15,120 of them that were associated with telomere length. They then conducted a further validation in 890 and 270 healthy participants and found four SNPs that were significantly associated with telomere length. Specific cross-analysis with genetic polymorphisms and risk of bladder cancer showed that rs398652 was associated with a 19 percent overall reduced risk of bladder cancer. Furthermore, smoking especially augmented the risk for bladder cancer in those people having the other genetic variant, associated with shorter telomeres.

AACR President Elizabeth H. Blackburn, Ph.D., the Morris Herzstein professor of biology and physiology in the department of biochemistry and biophysics at the University of California San Francisco, won the Nobel Prize in 2009 for her role in the discovery of telomeres and the enzyme telomerase.

In an accompanying editorial published in Cancer Prevention Research, Blackburn said that studies to date have not found a genetic link between both telomere length and cancer, which provides solid confirmation to population studies that suggested a role for telomeres in cancer development. Although she stressed that the effect of interventions to lengthen telomeres would need to be tested in prospective studies, she said the finding was a major research advancement.

"It has shed light on the biology of early cancers and their initiating events. These advances now create unprecedented opportunities for novel approaches directed at prevention and early interception of cancer's deadly trajectory," said Blackburn.

Blackburn will become immediate past president of the American Association for Cancer Research at 12:30 p.m. ET on Monday, April 4, 2011.

Both Gu and Blackburn will make presentations at an AACR Annual Meeting press conference on Saturday, April 2 at 2:00 p.m. ET in room W313 of the Orange County Convention Center. Reporters who cannot attend in person can participate using the following information:

  • U.S. & Canada: (888) 647-7462
  • International: (201) 604-0169
  • Access Code: 244081


Contact: Jeremy Moore
American Association for Cancer Research

Related medicine news :

1. Genetic variation cuts bladder cancer risk, protects chromosome tips
2. Do At-Home Genetic Tests Tell Too Much and Explain Too Little?
3. Most Breast Tumors Have Unique Genetic Fingerprint, Study Finds
4. Canadian Journal of Cardiology publishes advice on genetic testing of inherited cardiac arrhythmias
5. Mouse cancer genome unveils genetic errors in human cancers
6. Home Genetic Tests May Need Doctors Involvement: Report
7. FDA Weighs Pros, Cons of Home Genetic Testing
8. Mix of Genetics and Stress Can Impair Mental Abilities
9. Leicester leads on heart attack genetic link discovery
10. Where are new schizophrenia drugs? Experts convene to explore genetic and epigenetic solutions
11. Researchers pinpoint genetic pathways involved in breast cancer
Post Your Comments:
(Date:6/26/2016)... ... ... blind and certified personal trainer is helping to develop a weight loss fitness plan that ... the two major problems leading the fitness industry today:, , All ... They don’t eliminate all the reasons people quit their exercise program , ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from reveals that ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... ... 24, 2016 , ... People across the U.S. are sharpening their pencils and ... essay contest in which patients and their families pay tribute to a genetic counselor ... National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
(Date:6/23/2016)... , , , WHEN: , , ... , , , LOCATION: , , , Online, with free registration ... PANELISTS:  , , , Frost & Sullivan,s Global Vice President of ... Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... witnessing an exceptional era. Several new demand spaces, such as innovative ...
(Date:6/23/2016)... announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. Colombia ... ... ... ... Astellas is a pharmaceutical ...
Breaking Medicine Technology: