Navigation Links
Genetic variation cuts bladder cancer risk, protects chromosome tips
Date:4/2/2011

ORLANDO - A common genetic variation links to both bladder cancer risk and to the length of protective caps found on the ends of chromosomes, scientists at The University of Texas MD Anderson Cancer Center reported today at the AACR 102nd Annual Meeting.

These endings or tips, called telomeres, guard against chromosomal damage and genomic instability that can lead to cancer and other diseases.

"We found a single point of variation in the genome strongly associated with a 19 percent decrease in bladder cancer risk. The same variant also is linked to longer telomeres, which accounts for part of the overall reduction in risk," said first author Jian Gu, Ph.D., assistant professor in MD Anderson's Department of Epidemiology.

Telomere length diminishes with age, Gu said, and short telomeres are associated with age-related diseases such as stroke, Alzheimer's disease, diabetes, cardiovascular disease and cancer.

Previous studies separately tied telomere length either to cancer risk or to genetic variation. The paper by Gu and colleagues is the first to make both connections.

"Understanding the complex genetic regulation of telomere length and its relation to the causes of bladder and other types of cancer will help develop therapies or lifestyle changes to reduce cancer risk," said senior author Xifeng Wu, M.D., Ph.D., professor and chair of MD Anderson's Department of Epidemiology.

Wu and colleagues in 2003 were the first to show that short telomeres increase the risk of bladder, lung, kidney and head and neck cancers in a human epidemiological study.

Start with 300,000 SNPs

The new findings were presented by Gu at the AACR annual meeting and simultaneously published in Cancer Prevention Research, an AACR journal.

AACR President Elizabeth Blackburn, Ph.D., the Morris Herzstein professor of biology and physiology at the University of California San Francisco, won the Nobe
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Do At-Home Genetic Tests Tell Too Much and Explain Too Little?
2. Most Breast Tumors Have Unique Genetic Fingerprint, Study Finds
3. Canadian Journal of Cardiology publishes advice on genetic testing of inherited cardiac arrhythmias
4. Mouse cancer genome unveils genetic errors in human cancers
5. Home Genetic Tests May Need Doctors Involvement: Report
6. FDA Weighs Pros, Cons of Home Genetic Testing
7. Mix of Genetics and Stress Can Impair Mental Abilities
8. Leicester leads on heart attack genetic link discovery
9. Where are new schizophrenia drugs? Experts convene to explore genetic and epigenetic solutions
10. Researchers pinpoint genetic pathways involved in breast cancer
11. Scientists Link Sets of Genetic Abnormalities to Autism Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic variation cuts bladder cancer risk, protects chromosome tips
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... induce a rapid weight decline, mainly in the first ... regain, despite continued dieting. The partial regain may ... now shows that improvements to health remain even if ... online in Diabetes Care (Print: February 2012) ...
... director of fellowship training in female pelvic medicine and ... Temple, Texas, has received an Honorary Fellowship from the ... Gynaecologists (RANZCOG). He has served as a mentor to ... Australia on a number of occasions for lectures and ...
... Reinberg HealthDay Reporter , TUESDAY, Dec. 20 (HealthDay ... who keep their blood pressure levels under control may add ... fact, those in the study who took medicine to lower ... risk of dying from cardiovascular disease over a 20-year period, ...
... New research from the University of Michigan suggests obesity can ... free market policies. A study of 26 wealthy nations ... restaurants per capita had much higher obesity rates compared to ... capita. "It,s not by chance that countries with ...
... GABLES, FL Approximately 80,000 industrial chemicals are in ... commerce each year in the United States, according to ... risks from exposure to harmful substances, James Englehardt, professor ... Miami, is proposing a new technique that is more ...
... of patients who see an internal medicine specialist before major ... patients to 90 per cent, new research has found. ... commonly agreed upon standards for which patients should have such ... Ka Shing Knowledge Institute of St. Michael,s Hospital and the ...
Cached Medicine News:Health News:More reasons to keep this New Year's weight loss resolution uncovered by Ben-Gurion U researchers 2Health News:More reasons to keep this New Year's weight loss resolution uncovered by Ben-Gurion U researchers 3Health News:Scott & White physician recognized by Royal Australian and New Zealand College 2Health News:Treating High Blood Pressure May Add Years to Life 2Health News:Treating High Blood Pressure May Add Years to Life 3Health News:Supersized market economy, supersized belly: Wealthier nations have more fast food and more obesity 2Health News:UM researcher develops new way to assess risk for chemicals 2Health News:Pre-surgery exam rates vary widely among hospitals 2
(Date:1/15/2014)... , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds ... to its store . (Photo: ... of population, consumption upgrade and policy support, ... seen rapid development over the years, with total ... 2006 to 9.85 billion yuan in 2012. ...
(Date:1/15/2014)... Jan. 15, 2014 As health officials across ... flu virus, select Meijer pharmacies in Michigan ... and strep throat to eligible patients, enabling Meijer pharmacists ... matching prescriptions, under strict protocol set by a physician ... Grand Rapids, Mich. -based retailer is collaborating with ...
(Date:1/15/2014)... Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... has received commitments from institutional investors to purchase ... Company,s common stock in an at-the-market registered direct ... The Company entered into definitive purchase ... Company agreed to sell an aggregate of 3,603,603 ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... GP Strategies Corporation (NYSE: GPX ... provider General Physics Corporation (GP), announced today that its ... repurchase program, replacing the existing authorization which has approximately ... management, at its discretion, to repurchase shares from time ...
... 27, 2011 Hologic, Inc. (Hologic or the Company) ... and supplier of premium diagnostics, medical imaging systems and ... women, today announced plans to release its fourth quarter ... close. In conjunction with the release, management will host ...
Cached Medicine Technology:GP Strategies Announces $5 Million Share Repurchase Program 2Hologic to Release Fourth Quarter Fiscal 2011 Operating Results on Monday, November 7, 2011 2
The Surgifresh mini has the same rugged construction as the Plume-inator. It is the ideal size for operating room, clinic and office settings. This unit includes a filter test button, hospital grade ...
... for the phakic eye, clinically validated ... of vision and visual acuity comparable ... is compatible with current cataract surgical ... the correction of myopia in whole ...
... VitalVac's advanced technology makes ... to evacuate surgical plume. ... O.R. environment is "smoke-free", ... staff safe from potentially ...
Stryker Instruments, the leader in surgical helmets, offers its 4th generation of personal protection systems for todays surgical environment the Sterishield T4 System....
Medicine Products: