Navigation Links
Genetic variants affect arsenic metabolism and toxicity in Bangladesh
Date:2/23/2012

A large-scale genomic study conducted in Bangladesh has discovered genetic variants that control arsenic metabolism and elevate the risk of skin lesions in people chronically exposed to arsenic. In PLoS Genetics, researchers from the University of Chicago, Columbia University, the International Center for Diarrheal Disease Research in Bangladesh, and the University of North Carolina report that genetic variants found near the enzyme for metabolizing the chemical into a less toxic form are associated with an individual's risk of developing arsenic-related disease.

Since the installation of hand-pumped wells to tap groundwater sources in the 1970s, as many as 77 million people about half the population of Bangladesh have been accidentally exposed to dangerous levels of arsenic. The World Health Organization calls the exposure "the largest mass poisoning of a population in history" (WHO, 2000).

For over a decade, Habibul Ahsan and colleagues have studied the epidemiology of arsenic-related diseases such as skin lesions, diabetes, and cardiovascular and respiratory illnesses in this population, as well as the effectiveness of interventions to prevent toxicity. In this new study, nearly 3,000 Bangladeshis were genotyped for variants throughout the genome, in a search for answers as to why some individuals appear to be at higher risk for developing disease after arsenic exposure.

The research team found genetic variants associated with arsenic metabolite levels and skin lesion risk in the region of a likely candidate gene: arsenite methyltransferase, an enzyme critical for arsenic metabolism. A study of gene expression levels found that those same variants were associated with reduced expression of the enzyme. Boosting arsenic metabolism may be an effective intervention in individuals exposed to the toxin and at high genetic risk from arsenic-related disease.

"These results add clarity to the genetic architecture that is playing a role in the arsenic toxicity and its underlying biological basis," said Ahsan. "It's an important study for a major problem affecting millions of people around the world, and it opens up opportunities for genetic studies of other major public health problems in developing countries."


'/>"/>
Contact: Dr. Habibul Ahsan
habib@uchicago.edu
773-834-9956
Public Library of Science
Source:Eurekalert

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Obstructive Sleep Apnea in Kids May Have Genetic Cause
3. Epigenetic signals differ across alleles
4. Study reveals genetic link between mammographic density and breast cancer
5. Genetic Risk Score Doesnt Spot Heart Trouble in Women
6. Penn researchers find genetic link to leukemias with an unknown origin
7. Scientists Spot Genetic Fingerprints of Individual Cancers
8. Genetic health risks in children of assisted reproductive technology
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Protecting the brain from of a deadly genetic disease
11. Protecting the brain from a deadly genetic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... January 19, 2017 , ... ... staff members in 2017 who are passionate about making a difference in the ... and headquartered in Tampa, UMA, a nonprofit healthcare educational institution, has more than ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Sam & Associates ... to commercial and residential clients in the California Bay Area, is launching a charity ... in the region. , Heart disease is the primary killer of adult men and ...
(Date:1/19/2017)... ... January 19, 2017 , ... Tribble Insurance Agency, a ... eastern Virginia region, is inaugurating a charity event to honor Chad Phillip Dermyer, a ... duty last year, Chad Phillip Dermyer and his fellow officers were conducting routine stops ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... St. Catherine’s ... Center. , Siena Center is a skilled nursing facility on the grounds of the ... semiprivate rooms. It recently was voted the best nursing home in Mississippi for the ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... 2017 Spring Create Real Impact contest from Impact Teen Drivers and California Casualty. ... http://www.createrealimpact.com . , Educational grants totaling $15,000 will be awarded for the ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 2017  Abaxis, Inc. (NasdaqGS: ABAX ), ... and consumables for the medical and veterinary markets worldwide, ... results for the third quarter fiscal year 2017, ended ... p.m. ET on Thursday, January 26, 2017.  The Company ... year 2017 after the market closes on Thursday, January ...
(Date:1/19/2017)... -- Shire plc (LSE: SHP, NASDAQ: ... Drug Administration (FDA) has acknowledged receipt of the Class ... SHP465, a long-acting, triple-bead, mixed amphetamine salts formulation. SHP465 ... Attention-Deficit/Hyperactivity Disorder (ADHD). The FDA is expected to provide ... designated Prescription Drug User Fee Act (PDUFA) action date. ...
(Date:1/19/2017)... January 19, 2017 While ... serious about reducing the FDA,s regulatory strictness as ... the medical drug industry, many of the leading ... clinical trials and development of advanced drug treatments ... with recent developments include:  Moleculin Biotech, Inc., (NASDAQ: ...
Breaking Medicine Technology: