Navigation Links
Genetic variants affect arsenic metabolism and toxicity in Bangladesh
Date:2/23/2012

A large-scale genomic study conducted in Bangladesh has discovered genetic variants that control arsenic metabolism and elevate the risk of skin lesions in people chronically exposed to arsenic. In PLoS Genetics, researchers from the University of Chicago, Columbia University, the International Center for Diarrheal Disease Research in Bangladesh, and the University of North Carolina report that genetic variants found near the enzyme for metabolizing the chemical into a less toxic form are associated with an individual's risk of developing arsenic-related disease.

Since the installation of hand-pumped wells to tap groundwater sources in the 1970s, as many as 77 million people about half the population of Bangladesh have been accidentally exposed to dangerous levels of arsenic. The World Health Organization calls the exposure "the largest mass poisoning of a population in history" (WHO, 2000).

For over a decade, Habibul Ahsan and colleagues have studied the epidemiology of arsenic-related diseases such as skin lesions, diabetes, and cardiovascular and respiratory illnesses in this population, as well as the effectiveness of interventions to prevent toxicity. In this new study, nearly 3,000 Bangladeshis were genotyped for variants throughout the genome, in a search for answers as to why some individuals appear to be at higher risk for developing disease after arsenic exposure.

The research team found genetic variants associated with arsenic metabolite levels and skin lesion risk in the region of a likely candidate gene: arsenite methyltransferase, an enzyme critical for arsenic metabolism. A study of gene expression levels found that those same variants were associated with reduced expression of the enzyme. Boosting arsenic metabolism may be an effective intervention in individuals exposed to the toxin and at high genetic risk from arsenic-related disease.

"These results add clarity to the genetic architecture that is playing a role in the arsenic toxicity and its underlying biological basis," said Ahsan. "It's an important study for a major problem affecting millions of people around the world, and it opens up opportunities for genetic studies of other major public health problems in developing countries."


'/>"/>
Contact: Dr. Habibul Ahsan
habib@uchicago.edu
773-834-9956
Public Library of Science
Source:Eurekalert

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Obstructive Sleep Apnea in Kids May Have Genetic Cause
3. Epigenetic signals differ across alleles
4. Study reveals genetic link between mammographic density and breast cancer
5. Genetic Risk Score Doesnt Spot Heart Trouble in Women
6. Penn researchers find genetic link to leukemias with an unknown origin
7. Scientists Spot Genetic Fingerprints of Individual Cancers
8. Genetic health risks in children of assisted reproductive technology
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Protecting the brain from of a deadly genetic disease
11. Protecting the brain from a deadly genetic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... , ... Development Team of Pixel Film Studios Announced The Release of TranSweep, ... transition tool will keep a consistent flow to your project while adding interesting visuals ... TranSweep is an all new layered style transition tool for Final Cut Pro ...
(Date:5/26/2016)... , ... May 26, 2016 , ... In Madeira Beach ... mainland by a single drawbridge, citizens formed an organization, Madeira Beach United, to oppose ... and change the small town center to a high rise urban environment. , According ...
(Date:5/26/2016)... ... 2016 , ... According to the Webster’s dictionary, a hippie is defined as ... one company is going against the norm with a line of all-natural skincare that’s ... the green space is proud to announce its latest retail partnership with the Vitamin ...
(Date:5/26/2016)... California (PRWEB) , ... May 26, 2016 , ... ... Barbara this Memorial Day weekend to host their second pop-up shop for three ... Diego fashion forward brand to the Santa Barbara community, a community full of ...
(Date:5/26/2016)... Malvern, PA (PRWEB) , ... May 26, 2016 ... ... Sharon Wolf has been hired as FluidEdge’s Vice President of Business Intelligence and ... health analytics, Wolf has demonstrated success leading teams as a healthcare business and ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016 Digital Health Dialog, ... it by the US Patent and Trademark Office ... includes proprietary processes for electronic opt-­in and processing ... wellness programs, HIPAA compliance and otherwise. ... "Our technology allows for individuals ...
(Date:5/24/2016)... , May 24, 2016 ... den Markt gebracht, die es Ärzten erlaubt, ihre ... zu behandeln: MDLinking kombiniert Live Streaming mit einer ... Umfeld zu kommunizieren. Mediziner in Europa, Afrika, Asien ... sich bereits für die Plattform registriert. ...
(Date:5/24/2016)... , May 24, 2016  Diana Russell suffers ... her organs from the inside out.  This disease has ... dependent on her children and grandchildren to leave her ... wheelchair, Diana,s family cannot haul the wheelchair.  So if ... the car, and Diana is left to wait for ...
Breaking Medicine Technology: