Navigation Links
Genetic variants, tobacco exposure and lung cancer risk
Date:4/25/2012

There is an association between the rs1051730-rs16969968 genotype and objective measures of tobacco exposure, which indicates that lung cancer risk is largely, if not entirely, mediated by level of tobacco exposure, according to a study published April 25 in the Journal of the National Cancer Institute.

The rs1051730-rs16969968 genotype is known to be associated with heaviness of smoking, lung cancer risk, and other smoking-related outcomes. Prior studies have generally depended on self-reported smoking behavior, which may have underestimated associations and masked the contribution of heaviness of smoking to the associations of these polymorphisms with lung cancer and other health outcomes.

In order to determine the association between the rs1051730-rs16969968 genotype and self-reported cigarette consumption and plasma or serum cotinine levels, Marcus R. Munaf, Ph.D., of the School of Experimental Psychology at the University of Bristol and colleagues, examined data from six independent studies that looked at self-reported daily cigarette consumption and plasma or serum cotinine levels among cigarette smokers and conducted a meta-analysis of pooled per-allele effects. In addition, the researchers looked at the link between the genotypes and lung cancer risk using published data on the association between cotinine levels and lung cancer risk.

The researchers found that the rs1051730-rs16969968 genotype is strongly associated with tobacco exposure measured through cotinine levels, and that the association is strong even after adjustment for self-reported cigarette consumption. "These data therefore support the conclusion that association of rs1051730-rs16969968 genotype with lung cancer risk is mediated largely, if not wholly, via tobacco exposure," the researchers write.

The researchers point out certain limitations of the study, however, namely that the data were drawn from disparate studies from various populations
'/>"/>

Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Study of half siblings provides genetic clues to autism
2. Certain Genetic Regions May Be Tied to Osteoporosis
3. Head, Body Lice Are Genetically Very Similar
4. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
5. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
6. Genetic causes found in nearly 1 in 5 patients with dilated cardiomyopathy heart failure
7. Research uncovers genetic marker that could help control, eliminate PRRS virus
8. PCP genetic pathway acts as stop sign for cell growth
9. Genetic profiling can help doctors more accurately predict prognosis and guide treatment decisions for leukemia patients
10. From Refrigerator Mothers to untangling the genetic roots of autism
11. Genetic Tweak Helps Mice Avoid Cancer, Obesity: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... Dubuque, IA (PRWEB) May 21, 2013 Nearly ... took time out of an award trip in Los Cabos, ... Dia, a “day house” for the elderly. , The facility ... elderly residents of San Jose del Cabo, Mexico. , Platinum ... project began while reflecting on the company’s history. , “Platinum ...
(Date:5/21/2013)... Everspark Interactive, one of the city's leading ... over the past year – and announced another milestone ... marketing efforts for Kids II, a designer of innovative ... a local effort, specializing in search engine optimization (SEO) ... company's website. The company now offers a host of ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Workplace ... world’s leading work-life services provider, and Mayo Clinic ... wellness services. In an initiative set to launch ... Clinic’s coaching model into its existing suite of ... Clinic’s current commercial client base in addition to ...
(Date:5/21/2013)... AAG Health, the leading age management and hormone ... has acquired the OligoScan test made by leading European ... technology, the OligoScan device is capable of measuring in ... metals, 20 trace elements (minerals), and oxidative stress levels. ... as mercury, lead, aluminum, and arsenic, will make it ...
(Date:5/21/2013)... Thousands of Americans, many of them smokers or ... chronic obstructive pulmonary disease (COPD). Now a new ... antibiotic azithromycin may be able to cut down ... "Given that exacerbations of COPD can be ... Victoria Richards, assistant professor of medical science at ...
Breaking Medicine News(10 mins):Health News:Platinum Supplemental Insurance Gives Back at Casa De Dia, Mexico 2Health News:Platinum Supplemental Insurance Gives Back at Casa De Dia, Mexico 3Health News:Everspark Named Interactive Marketing Company for Kids II 2Health News:Workplace Options and Mayo Clinic Announce Strategic Relationship 2Health News:Workplace Options and Mayo Clinic Announce Strategic Relationship 3Health News:AAG Health is the First Age Management Center in Florida to Offer the OligoScan 2Health News:AAG Health is the First Age Management Center in Florida to Offer the OligoScan 3Health News:Long-Term Use of Antibiotic May Help Those With COPD 2Health News:Long-Term Use of Antibiotic May Help Those With COPD 3
... ... Health Insurance (SCHIP) Bill, HARRISBURG, Pa., Oct. 3 ... (PCCY) today expressed deep disappointment with President Bush,s veto,of the ... passed by the House and Senate last week, provides,health insurance ...
... Comments on Company,s Restructuring, Recovery and Revitalization, ... of,PainCare Holdings, Inc. (Amex: PRZ ), one ... surgical solutions and services, today issued,the following corporate ... impact and support the Company,s refined long term,growth ...
... (Nasdaq: FLEX ) today announced that, in ... October 1,2007, Solectron Global Finance Ltd. notified holders ... ("8% Notes") that it is exercising,its right to ... to the optional,redemption procedures provided for under the ...
... Campaign Urges Enrollment, LOS ANGELES, Oct. 3 ... clinical trials are being conducted to seek a,treatment, perhaps ... fatal,autoimmune disease that affects more than 1.5 million Americans ... question that clinical trials answer is, "Will this drug ...
... Paragon Technologies,Inc. (Amex: PTG ), a ... warehouse and distribution center solutions,announced today that its ... million to provide an automated light-picking system and ... line of healthcare,products. The contract calls for SI ...
... to Home and the ... Workplace, Company Develops Community Educational Partnership with St. ... System in Orange ... provider of,retail-based health care in the United States, has opened 14 health care,centers at ...
Cached Medicine News:Health News:PA Advocates Ask President Bush, 'What about the Kids??' 2Health News:PainCare Reports on Key Corporate Developments 2Health News:PainCare Reports on Key Corporate Developments 3Health News:PainCare Reports on Key Corporate Developments 4Health News:PainCare Reports on Key Corporate Developments 5Health News:Flextronics Announces Redemption and Change of Control Repurchase Offer for Solectron 8.00% Senior Subordinated Notes and Planned Change of Control Repurchase Offer for Solectron's 0.50% Senior Convertible Notes 2Health News:Clinical Trials for Lupus Underway After Decades of Drought 2Health News:Paragon Technologies' SI Systems Brand Awarded A $1.0 Million System Expansion Contract for an Automated Light-Picking System 2Health News:Paragon Technologies' SI Systems Brand Awarded A $1.0 Million System Expansion Contract for an Automated Light-Picking System 3Health News:An Innovation in Health Care Opens at CVS/pharmacy Stores in Los Angeles Metro Area 2Health News:An Innovation in Health Care Opens at CVS/pharmacy Stores in Los Angeles Metro Area 3Health News:An Innovation in Health Care Opens at CVS/pharmacy Stores in Los Angeles Metro Area 4Health News:An Innovation in Health Care Opens at CVS/pharmacy Stores in Los Angeles Metro Area 5Health News:An Innovation in Health Care Opens at CVS/pharmacy Stores in Los Angeles Metro Area 6
(Date:5/21/2013)... 21, 2013  Zacks.com announces the list of stocks ... Equity Research analysts discuss the latest news and events ... in the blog include Actavis, Inc.,s (NYSE: ACT ... (NYSE: TOT ), Petrobras (NYSE: PBR ) ... (Logo: http://photos.prnewswire.com/prnh/20101027/ZIRLOGO ) Get ...
(Date:5/21/2013)... , May 21, 2013  Cephasonics, ... platform, today announced the introduction of the ... complete network-based communications with all cQuest Ultrasound™ ... embedded-ultrasound technology, including this new capability, at ... Paulo, Brazil from May 21-24.  ...
(Date:5/21/2013)... May 21, 2013  Vasomedical, Inc. (OTC BB: VASO) (the ... manufacture and sale of medical devices and in the domestic ... Jun Ma , President and CEO of Vasomedical, ... Conference on Thursday, May 30, 2013 in New ... The Company,s presentation is scheduled to begin at ...
Breaking Medicine Technology:The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 2The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 3The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 4The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 5Cephasonics Unveils Next-Generation Wireless-Imaging Technology for cQuest Ultrasound Hardware Platforms 2Vasomedical, Inc. To Present At The Second Annual Marcum LLP MicroCap Conference 2
... new Propaq LT is the perfect monitor ... basic parameters of continuous vital signs monitors ... making it perfect for just about any ... Light enough to clip on an IV ...
Exxcel Soft ePTFE vascular graft, designed for exceptional kink resistance and crush resistance, maintains a Soft touch for easier handling during peripheral vascular bypass procedures and vascular a...
... is used for the processing ... independent medical billers. It is ... generate and transmit claims to ... commercial insurance carriers. It utilizes ...
BillingPro...
Medicine Products: