Navigation Links
Genetic trait could triple odds of whites' susceptibility to heavy cocaine abuse
Date:12/21/2010

deepen the cocaine craving and lead to heavy abuse? And how strong is the overall effect of this trait?

But what the research does show is the first strong connection in brain tissue between the mutations and the presence of severe cocaine abuse.

"We now have both good biological rationale and clinical association showing that this has an impact on the way cocaine abuse might progress or might be initiated," said Wolfgang Sadee, professor of pharmacology and director of the Program in Pharmacogenomics at Ohio State and senior author of the study. "We have found a frequent variant in one of the key candidate genes that can affect cocaine abuse, but more importantly, it also opens the avenue to explore how this variant affects response to therapies for a variety of psychiatric disorders that involve dopamine."

The research appears online and is scheduled for later print publication in the journal Neuropsychopharmacology.

The mutations described in this study are single-nucleotide polymorphisms, or SNPs (pronounced "snips"). Each gene contains two alternative forms called alleles that are identical in most people. However, in some cases, the activity level, or expression, of an allele can differ from its partner allele in a single gene. Each small difference is a SNP.

SNPs have become the primary study target of Ohio State's Program in Pharmacogenomics. But the mutations Sadee studies aren't just any SNPs. Up until about 10 years ago, most biological research focused on these tiny mutations in areas of genes that produce proteins. But Sadee's lab explores the role of SNPs that are present earlier in a gene's existence, located in regions called introns.

A better understanding of the human genome has led scientists to determine that about 90 percent of the mutations that can lead to disease or govern behavior actually are located in these deeper and often overlooked regions of genes, and that they regulate
'/>"/>

Contact: Wolfgang Sadee
wolfgang.sadee@osumc.edu
614-292-1597
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. MRI scans reveal brain changes in people at genetic risk for Alzheimers
2. deCODE discovers genetic markers that improve the power of PSA testing for detecting prostate cancer
3. Scientists Spot Genetic Areas Key to Embryonic Development
4. Genetic Research Sheds Light on Adrenal Gland Tumor Risk
5. Rare Genetic Syndrome May Increase Colon Cancer Risk
6. Chinese Study Suggests New Way to Test for Genetic Diseases
7. New discovery prevents symptoms of rare genetic disorder
8. Genetic mutations associated with increased PSA and prostate cancer
9. Novel genetic mutation that causes the most common form of eye cancer discovered
10. Rare, Severe Form of Morning Sickness Appears to Be Genetic
11. Our normal genetics may influence cancer growth, too
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The City of West Hollywood hosted a news ... the 42nd anniversary of the Supreme Court decision Roe v. Wade, ... years since the Roe vs. Wade decision and the fight to ... ever,” said City of West Hollywood Councilmember Abbe Land. “We need ...
(Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who consistently delivers ... to have it lead the wedding dress industry into the ... dresses for the global market. , “The CEO of VogueQueen ... focuses on continuing the goal of operational excellence and giving ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has ... View website of AngelWeddingDress.com to find more ... dresses online for a bridal party. AngelWeddingDress offers a ... them. Its maternity wedding dresses are specially designed for ...
(Date:1/22/2015)... York (PRWEB) January 22, 2015 Thousand ... Fresenius Medical Care recalled its GranuFlo and NaturaLyte dialysis ... litigation underway in U.S. District Court, District of Massachusetts, ... January 20th, the Court has remanded a case filed ...
(Date:1/22/2015)... 22, 2015 Joan Lunden, award-winning American ... at the upcoming 32nd Annual Miami Breast Cancer ... Education Resource®, LLC (PER®) , shares that “a fast-growing, ... undetected if she had not followed up her clean ...
Breaking Medicine News(10 mins):Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
... milk and in their interest to shed weight, completely knock ... was conducted recently with 19,000 middle-age women, habituated to consume ... finding revealed that such women had gained less weight as ... ,Supporting the previous endeavors underlining the benefits of calcium ...
... by Dr. Martijn B.A. van Doorn of the Center for ... people revealed that garlic has no significance// in controlling their ... which was published in the American Journal of Clinical Nutrition ... hypothesis on garlic and its positive influence on heart diseases. ...
... again. Doctors have been on strike last three days, protesting ... by a police officer. ,Dr Ashokan has been accused ... Medical College hospital through acts of ‘negligence’ and ‘corruption’. ... College Students Union called the strike. , The doctors of ...
... A survey by the New South Wales health department in ... its influence on health. ,The study conducted over ... to a survey. The results showed that a greater proportion ... in comparison with others. ,New Zealanders were physically more ...
... Sunday at the Apollo //Hospital. ,Dr Pankaj Mahendru, director ... the city of the Taj Mahal. ,"The surgery, ... Das Baba and Dr Bhavna Singh with their team of ... has many achievements to its credit. Last year the hospital ...
... Severe respiratory illness caused by deadly viruses has led Children's ... ,Children affected by Respiratory Syncytial Virus (RSV) occupy all ... Dr. Cheryl Greenberg of the Winnipeg Regional Health Authority. ... are hooked up to a machine that helps move air ...
Cached Medicine News:Health News:Kerala Doctors on Strike 2
(Date:1/23/2015)... Jan. 23, 2015  HyGreen, Inc., a leader in hand ... with RCA Medical, a subsidiary of Ascendis Health Limited, ... Each year, hundreds of millions of patients around ... organisms are transmitted from patient to patient via the ...
(Date:1/23/2015)... , Jan. 23, 2015 Cord Blood America, Inc. ... ("CBAI" or the "Company")  filed a Preliminary Proxy Statement, Schedule ... ) today, and provides an update for shareholders detailing why ... is requested. Dear Shareholders, As we ...
(Date:1/23/2015)... Ala. , Jan. 23, 2015 Gem Pharmaceuticals ... patients have been enrolled into the Company,s Phase 2 ... and safety of Gem,s lead compound, GPX-150 (an investigational ... advanced or metastatic disease. Logo - ...
Breaking Medicine Technology:HyGreen Partners with RCA Medical in Johannesburg, South Africa 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2
... Recommendation on Sibutramine -- ABBOTT PARK, Ill., Sept. 15 ... ... ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var ...
... has announced the winners of the second 2010 Transplant Scholars ... recipients and living donors from around the country to help ... to make a real difference in the lives of the ... entries by a panel of judges who evaluated the essays ...
Cached Medicine Technology:Abbott Statement on the FDA Advisory Committee Recommendation on Sibutramine 2Abbott Statement on the FDA Advisory Committee Recommendation on Sibutramine 3Abbott Statement on the FDA Advisory Committee Recommendation on Sibutramine 4Abbott Statement on the FDA Advisory Committee Recommendation on Sibutramine 5Abbott Statement on the FDA Advisory Committee Recommendation on Sibutramine 6Abbott Statement on the FDA Advisory Committee Recommendation on Sibutramine 7Abbott Statement on the FDA Advisory Committee Recommendation on Sibutramine 8Abbott Statement on the FDA Advisory Committee Recommendation on Sibutramine 9Astellas Awards Scholarships to 12 Transplant Recipients and Donors Who Embody Hope, Courage and Achievement 2Astellas Awards Scholarships to 12 Transplant Recipients and Donors Who Embody Hope, Courage and Achievement 3Astellas Awards Scholarships to 12 Transplant Recipients and Donors Who Embody Hope, Courage and Achievement 4Astellas Awards Scholarships to 12 Transplant Recipients and Donors Who Embody Hope, Courage and Achievement 5Astellas Awards Scholarships to 12 Transplant Recipients and Donors Who Embody Hope, Courage and Achievement 6Astellas Awards Scholarships to 12 Transplant Recipients and Donors Who Embody Hope, Courage and Achievement 7Astellas Awards Scholarships to 12 Transplant Recipients and Donors Who Embody Hope, Courage and Achievement 8
CO2 gas object holder and knife freezer for the 8000 Series Sliding Microtome...
Steel Knife with box for the Series 8000 Sliding Microtome. C-Profile, 240 x 33 x13m, 22 Degree angle, tapped to accept holder for Shandon knife sharpener....
Allows for custom orientation of specimen...
Honing compound for knife sharpening, 6 grams net...
Medicine Products: