Navigation Links
Genetic trait could triple odds of whites' susceptibility to heavy cocaine abuse
Date:12/21/2010

COLUMBUS, Ohio Nearly one in five whites could carry a genetic variant that substantially increases their odds of being susceptible to severe cocaine abuse, according to new research.

This genetic variant, characterized by one or both of two tiny gene mutations, alters the brain's response to specific chemical signals. In the study, led by Ohio State University researchers, the variant was associated with a more than threefold increase in the odds that carriers will be susceptible to severe cocaine abuse leading to fatal overdosing, compared to non-carriers.

Among whites, one or both mutations were found in more than 40 percent of autopsy brain samples taken from people who had abused cocaine, compared to 19 percent of samples from people who lived drug-free. Overall, one in five samples from whites in the control group and one in two to three samples in the cocaine overdose group contained the genetic variant, compared to one in eight African Americans, in whom the variant is less prevalent.

The mutations either alone or in combination affect how dopamine modulates brain activity. Dopamine, a neurotransmitter, is a chemical messenger vital to the regular function of the central nervous system. Previous research has established that cocaine blocks dopamine transporters from absorbing dopamine after its release, leaving the chemical outside the brain cells and creating a feeling of euphoria.

In people who carry one or both of the mutations, the function of a gene responsible for transmitting dopamine signals in the brain is altered. Researchers speculate that this altered gene function sets up a vicious circle of chemical signals that could lead to a craving for a substance that can maintain elevated levels of dopamine in the brain.

The researchers say many questions about cocaine abuse susceptibility remain unanswered: Do the mutations increase the chances someone will try cocaine in the first place? Or do they
'/>"/>

Contact: Wolfgang Sadee
wolfgang.sadee@osumc.edu
614-292-1597
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. MRI scans reveal brain changes in people at genetic risk for Alzheimers
2. deCODE discovers genetic markers that improve the power of PSA testing for detecting prostate cancer
3. Scientists Spot Genetic Areas Key to Embryonic Development
4. Genetic Research Sheds Light on Adrenal Gland Tumor Risk
5. Rare Genetic Syndrome May Increase Colon Cancer Risk
6. Chinese Study Suggests New Way to Test for Genetic Diseases
7. New discovery prevents symptoms of rare genetic disorder
8. Genetic mutations associated with increased PSA and prostate cancer
9. Novel genetic mutation that causes the most common form of eye cancer discovered
10. Rare, Severe Form of Morning Sickness Appears to Be Genetic
11. Our normal genetics may influence cancer growth, too
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... to be proactive about potential disease outbreaks like Ebola ... In an Editorial in the October issue of ... Allen Cheng from Monash University and Heath Kelly from ... health crises. , "Australia would do well to heed ... in co-ordinating a consistent and outward looking response," the ...
(Date:9/30/2014)... By Dennis Thompson ... -- The first confirmed case of Ebola has surfaced in ... from Liberia, federal health officials announced late Tuesday. The ... Hospital in Dallas, has been diagnosed with the deadly ... Prevention said in a late afternoon news conference. The ...
(Date:9/30/2014)... climate-changing carbon emissions will reduce other harmful air ... to a new study released today. The research ... in the final Clean Power Plan, the power ... and hospitalizations, and hundreds of heart attacks in ... study, Health Co-benefits of Carbon Standards for Existing ...
(Date:9/30/2014)... Sleep apnea is a potential health risk for millions of ... behind the disorder: a "fat" tongue. "This is the ... the tongue of obese patients with obstructive sleep apnea," study ... at the University of Pennsylvania Medical Center, said in a ... findings Oct. 1. Sleep apnea is a common disorder ...
(Date:9/30/2014)... Keystone Symposia will convene the first conference of its ... Health Series on "The Modes of Action of ... following the conclusion of the Grand Challenges Meeting for ... the Keystone Symposia Global Health Series, supported by the ... travel awards for 36 investigators from developing countries to ...
Breaking Medicine News(10 mins):Health News:CDC Confirms First Patient Diagnosed With Ebola in United States 2Health News:CDC Confirms First Patient Diagnosed With Ebola in United States 3Health News:Power plant standards could save thousands of US lives every year 2Health News:Power plant standards could save thousands of US lives every year 3Health News:Could a 'Fat Tongue' Be a Factor in Sleep Apnea? 2Health News:Keystone Symposia launches 2014-2015 meeting series with Global Health Vaccines Conference 2
... on their way to office or back home, with the ... Manchester Piccadilly train stations//. This patient friendly system eliminates ... from 7 a.m. to 7 p.m. ,Such a ... for the request of the general public, demanding a quick ...
... effective anti-depressant is also found to interact with immune ... mechanism of serotonin inhibitors on human health//. ... Georgetown University Medical center have found that SSRI (Selective ... an effective antidepressant by passing between the neurons ...
... Researchers have identified an increased incidence of melanoma among the ... the March 1, 2006 issue// of CANCER, a peer-reviewed journal ... melanoma- an invasive form of skin cancer- is of the ... ,It is generally accepted that melanoma is by far ...
... who use vaginal washes run a higher risk of contracting HIV/AIDS.// ... led by Scott McClelland. The women who live in the sub-Saharan ... Kenyan women were examined during the course of the study. ... they washed with soap were four times more likely to be ...
... in the lymph nodes also, according to a recent research, ... mammalian immune response. // ,The dreaded disease ... mammal, and the immature parasites travel to the animal's liver. ... the liver cells and infect red blood cells, beginning the ...
... provided by researchers that faith healing and special diets also ... Melbourne led the research // which studied as many as ... served to extend the life of 25 people for a ... ,Dr Macmanus said that the data showed ...
Cached Medicine News:Health News:Invasive Skin Cancer On The Rise in Hispanics 2Health News:Malaria Can Develop In Lymph Nodes Also 2
(Date:9/30/2014)... Sept. 30, 2014 The signing of ... and New Jersey Health Foundation (NJHF) to work ... care programs has been announced by Rodger ... Kessler Foundation and James M. Golubieski , ... "The experience of New Jersey Health Foundation in ...
(Date:9/30/2014)... NEWPORT BEACH, Calif. , Sept. 30, 2014 ... prestigious accreditation of the American Association of Tissue ... Russell Cook , Chief Executive Officer. ... on-site inspection by a specially trained AATB inspector.  ... and administrative performance within the facility meets or ...
(Date:9/30/2014)... , Sept. 30, 2014 The Eastern European ... established medical-device providers as well as new medical-device manufacturers ... while simultaneously looking at ways to reduce the cost ... distributors is one of the effective means to achieve ... distribution market in Eastern European and provides profiles of ...
Breaking Medicine Technology:Kessler Foundation Partners with New Jersey Health Foundation To Start Innovative Companies To Change the Lives of People with Disabilities 2Biostructures, LLC Earns AATB Accreditation 2Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3
... SAN DIEGO, Dec. 5, 2011 ForteBio®, Inc., a ... of biotherapeutic and pharmaceutical products, today announced the launch ... scientists – for the first time – to conduct ... and cost-efficiently at their lab bench. The new platform ...
... Bupa International has published two new health guides for ... information on vaccinations, medical insurance and emergency healthcare. ... a growing number of people relocate to foreign countries ... region is particularly needed, as the area,s many booming ...
Cached Medicine Technology:ForteBio Introduces BLItz™, a Revolutionary, Micro-volume Label-free Analysis Platform for Personal Assays 2ForteBio Introduces BLItz™, a Revolutionary, Micro-volume Label-free Analysis Platform for Personal Assays 3Bupa International Releases Health Guides to Hong Kong and Singapore 2
... first fully automated blood ... North American market based ... Test™. The ORTHO ProVue™ ... while increasing productivity via ...
The ScanGel® automatic readings are done with a high resolution color video camera. Images can be stored and printed....
... are in need of MRI exams, many ... scanners. They have heard of, or experienced ... and noisy tubes of supercon scanners - ... people want is a patient-friendly MRI. Now ...
... early 1990s, the "Reversed" shoulder prosthesis has ... great success. More recently, an ever-growing number ... begun to champion this prosthesis and the ... This reversed technology is the result of ...
Medicine Products: