Navigation Links
Genetic tracking identifies cancer stem cells in human patients
Date:5/15/2014

pagated into other cancer cells, they demonstrated that a distinct and rare subset of MDS cells showed all the hallmarks of cancer stem cells, and that no other malignant MDS cells were able to propagate the tumour.

The MDS stem cells were rare, sat at the top of a hierarchy of MDS cells, could sustain themselves, replenish the other MDS cells, and were the origin of all stable DNA changes and mutations that drove the progression of the disease.

'This is conclusive evidence for the existence of cancer stem cells in myelodysplastic syndromes,' says Dr Woll. 'We have identified a subset of cancer cells, shown that these rare cells are invariably the cells in which the cancer originates, and also are the only cancer-propagating cells in the patients. It is a vitally important step because it suggests that if you want to cure patients, you would need to target and remove these cells at the root of the cancer but that would be sufficient, that would do it.'

The existence of cancer stem cells has already been reported in a number of human cancers, explains Professor Jacobsen, but previous findings have remained controversial since the lab tests used to establish the identity of cancer stem cells have been shown to be unreliable and, in any case, do not reflect the "real situation" in an intact tumour in a patient.

'In our studies we avoided the problem of unreliable lab tests by tracking the origin and development of cancer-driving mutations in MDS patients,' says Professor Jacobsen, who also holds a guest professorship at the Karolinska Institutet.

Dr Woll adds: 'We can't offer patients today new treatments with this knowledge. What it does is give us a target for development of more efficient and cancer stem cell specific therapies to eliminate the cancer.

'We need to understand more about what makes these cancer stem cells unique, what makes them different to all the other cancer cells. If we can find biologic
'/>"/>

Contact: University of Oxford
news.office@admin.ox.ac.uk
44-186-528-0530
University of Oxford
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Large panel genetic testing produces more questions than answers in breast cancer
2. Researchers identify genetic marker linked to OCD
3. Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
4. Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
5. Few women at high-risk for hereditary breast and ovarian cancer receive genetic counseling
6. Genetic, environmental influences equally important risk for autism spectrum disorder
7. Vanderbilt study explores genetics behind Alzheimers resiliency
8. Brain tumor cells penetrated by tiny, degradable particles carrying genetic instructions
9. Identification of genetic mutations involved in human blood diseases
10. Genetic alterations in shared biological pathways as major risk factor for ASD
11. Non-uniform genetic mutations identified in lung cancers could lead to targeted treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... BC (PRWEB) February 28, 2015 Vancouver personal ... personal injury claims are affected by time limits. They stated ... weaken a person’s claim or even nullify it. Many a ... effects on a client’s rights under BC law. As a ... are affected by accidents should consult a personal injury lawyer ...
(Date:2/28/2015)... 28, 2015 The Mesothelioma Applied ... awards at the International Symposium on Malignant Mesothelioma on ... at the Hyatt Regency Bethesda in Bethesda, Maryland. The ... work and commitment to the mission to cure mesothelioma. ... will be presented to Miriam Ratner. Miriam runs the ...
(Date:2/28/2015)... FL (PRWEB) February 28, 2015 ... organization has sponsored visitor health insurance programs for visitors ... years. Most Indian elderly parents traveling to the United ... such as diabetes and blood pressure. These diseases are ... not even list them as medical conditions. There were ...
(Date:2/28/2015)... NY (PRWEB) February 28, 2015 On Thursday, ... Kits Make It Easy For Scammers To Steal Your Data ... can get their hands on a DIY phishing kit, or ... it also touched on another important point about how everyone’s ... kits are often implemented, “like compromising legitimate content management systems ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 Javon ... recognizes Mercy Harvard Hospital as stroke capable by the ... brought via ambulance to Mercy Harvard Hospital. , The ... to indicate their ability to treat stroke according to ... allows ambulances transporting stroke patients to bypass hospitals not ...
Breaking Medicine News(10 mins):Health News:Jiwa Law Corporation Recently Announced That Time Delays May Weaken Personal Injury Claims 2Health News:Cancer Research Foundation Honors Award Recipients 2Health News:Cancer Research Foundation Honors Award Recipients 3Health News:Cancer Research Foundation Honors Award Recipients 4Health News:India Network Announces Pre-existing Condition Health Insurance Coverage for Diabetic Visitors of All Ages Traveling to the United States 2Health News:India Network Announces Pre-existing Condition Health Insurance Coverage for Diabetic Visitors of All Ages Traveling to the United States 3Health News:DIY Phishing and Malware Kits Make it Easy to Compromise Businesses in More Ways than One 2Health News:DIY Phishing and Malware Kits Make it Easy to Compromise Businesses in More Ways than One 3Health News:DIY Phishing and Malware Kits Make it Easy to Compromise Businesses in More Ways than One 4Health News:Mercy Harvard Hospital Recognized as Leader in Stroke Care - Javon Bea 2
... , FRIDAY, Nov. 11 (HealthDay News) -- A ... problems later in life, a new study suggests. ... than athletes in non-contact sports and non-athletes to suffer cognitive ... of Missouri researchers assessed former college football players and found ...
... CA NOVEMBER 11, 2011 A clinical ... (DES) in native coronary arteries found that treatment ... plain old uncoated-balloon angioplasty (POBA). Results from the ... 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, ...
... FRIDAY, Nov. 11 (HealthDay News) -- Age-related declines in ... to a new study. "The more income and ... be," co-author Virginia Richardson, a professor of social work ... release. The researchers analyzed data from roughly 6,500 ...
... HealthDay Reporter , THURSDAY, Nov. 10 (HealthDay News) -- Adults ... have less gray matter in certain areas of their brains ... youth, researchers say. "The majority of individuals with ... to see that even with improvement, there continue to be ...
... CHAPEL HILL, N.C. -- A new study finds that people ... any pain medication in hospital emergency departments than middle aged ... And these differences remained even after researchers took into account ... Platts-Mills, MD, lead author of the study and assistant professor ...
... , THURSDAY, Nov. 10 (HealthDay News) -- Despite the known ... up, but almost 70 percent want to quit, a new ... Dr. Tim McAfee, director of the Office on Smoking and ... said during a noon press conference Thursday. There was ...
Cached Medicine News:Health News:Former Football Players' Brains May Benefit From Healthy Lifestyle 2Health News:Results of the PEPCAD-DES trial reported at TCT 2011 2Health News:ADHD Brain Changes Appear to Persist Into Adulthood 2Health News:ADHD Brain Changes Appear to Persist Into Adulthood 3Health News:Elderly emergency patients less likely to receive pain medication than middle-aged patients 2Health News:Most Smokers Want to Quit, CDC Report Finds 2Health News:Most Smokers Want to Quit, CDC Report Finds 3Health News:Most Smokers Want to Quit, CDC Report Finds 4
(Date:2/27/2015)... N.C. , Feb. 27, 2015 The ... the past decade but one thing hasn,t changed: face-to-face ... to build relationships with Key Opinion Leaders. ... as the most valuable type of interaction, field medical ... on their KOL interactions. This is just one of ...
(Date:2/27/2015)... 2015  Pharmacyclics, Inc. (NASDAQ: PCYC ... published in the Proceedings of the National ... showed when ibrutinib (IMBRUVICA ® ) was combined ... of tumor growth was enhanced suggesting a greater ... cancers and solid tumors with the combination. IMBRUVICA ...
(Date:2/27/2015)... 27, 2015 ... sistema di monitoraggio dell,infarto congestizio (CHF - Congestive ...     Vectorious Medical ... sistema per il monitoraggio cardiaco destinato a pazienti ... di aver concluso una raccolta di finanziamenti per ...
Breaking Medicine Technology:Improving the Management of MSL Teams to Create Value across a Diverse Set of Customers 2In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 2In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 3In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 4In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 5In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 6In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 7In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 8In Pre-Clinical Studies Ibrutinib Enhances Anti-tumor Activity When Combined With An Anti-PD-L1 Antibody 9Vectorious Medical Technologies completa una raccolta di 5 milioni di dollari 2
The Aaron 800-EU is designed and engineered to be the most reliable and durable desiccator available today....
Sabre 180 is a powerful niche generator....
The ExcaliburPlus PC is the most powerful isolated ESU with 10,000 V PTP in spray coag....
Malis CMC-III Generator provides both coagulation and cutting outputs....
Medicine Products: