Navigation Links
Genetic testing may be valuable in treating colorectal cancer
Date:7/27/2009

NEW YORK (July 27, 2009) -- For the 29,000 patients in the United States with metastatic colorectal cancer, chemotherapy with irinotecan is a standard treatment that has been shown to improve survival. But for more than one in 10 of these patients, a variation in their DNA means that this treatment could result in a severe reduction in their white blood cell count, leading to a high risk of bacterial infection and possible subsequent death. A new genetic test can identify those with the variation in order to lower the treatment dose -- however, it has been unclear whether the testing is worthwhile.

A new cost-effectiveness study led by scientists at Weill Cornell Medical College has determined that so-called pretreatment pharmacogenetic testing is only beneficial if dose-reduced treatment is shown to be nearly as effective as the full dose. If the lower dose is as effective, the test could prevent many cases of severe neutropenia, an abnormally low count of an important type of white blood cells known as neutrophils. It would also mean better life expectancy and lower cost of care.

The study appears online in the journal Cancer and is expected in print in the Sept. 1 issue.

"Pharmacogenetic testing is a relatively new treatment innovation that may prove to be a valuable tool for clinicians as they develop personalized treatments for cancer patients to minimize side effects while maintaining outcomes," says lead author Dr. Heather Taffet Gold, assistant professor in the Division of Health Policy in the Department of Public Health at Weill Cornell Medical College. "Our study points to significant potential benefits for pretreatment pharmacogenetic testing for metastatic colorectal cancer, but remains to be verified by clinical research."

The study used a computer simulation model that follows hypothetical patients treated with the FOLFIRI (5-fluorouracil/leucovorin with irinotecan) chemotherapy regimen for metastatic c
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH Plan Charts Course to Better Treatments and Cure for Most Common Known Genetic Cause of Autism: Fragile X
2. Studies Show Genetic Activity of Antioxidants
3. Genetic Variation Associated With Survival Advantage in African Americans With HIV
4. Study Shows a Link Between Schizophrenia & Genetic Mutations
5. Teen Behaviors Stem From Genetics, Environment
6. New HHS HRSA Grant Will Fund Development of an Electronic Genetic and Family History Record for Doctors Offices
7. Council for American Medical Innovation Applauds Appointment of Geneticist Francis Collins to Head National Institutes of Health
8. Genetic Breakthrough Spells Hope for Lung Fibrosis Patients
9. Buyer Beware! Know What Youre Getting When You Buy Online Genetic Tests
10. Moles and melanoma -- researchers find genetic links to skin cancer
11. Another Genetic Link to Testicular Cancer Is Found
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... is said that nothing makes a lady feel more feminine ... supplier, shows its new selection of navy cocktail dresses ... UWDress.com’s navy cocktail gowns are the cornerstones of the site’s ... Simple dresses in bright neon colors can be dressed up ... for those who want to shine among the crowd by ...
(Date:12/26/2014)... Plugin and template developers from Pixel Film Studios ... Cut Pro X. , “TransPack Volume 5 gives users the ... an industry professional look” Said Christina Austin, CEO of Pixel ... 5, a new level of professionalism will become the standard.” ... Final Cut Pro X transitions featuring organic animations. Choose from ...
(Date:12/26/2014)... (DaWei Induction Heating Co.) is a comprehensive high-tech business ... of a series of induction heating equipment. Today, the ... induction brazing equipments . , According to a ... refers to the joining of two or more components ... says that there are fundamental differences in the two ...
(Date:12/25/2014)... The click strand woven ... and durability. Today, the business announces a click ... until Jan. 30, 2015. , Click strand woven ... BambooFlooringChina.com is a well-known brand in the bamboo ... find a reliable bamboo flooring supplier. , “We ...
(Date:12/25/2014)... “Every three months the trends for ... evening dress will be one of the hottest styles in ... says. Today, the company releases 26 A-line sweetheart evening dresses, ... off. , “We are trying our best to help ... latest designs. Along with affordable prices, we provide discounted delivery ...
Breaking Medicine News(10 mins):Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2
... clinics and hospitals in the United States as the International Brain ... the condition. Researchers believe that the quality and type of care ... , ... Denver, CO (PRWEB) August 26, 2008 -- ...
... (NASDAQ: QLTI;,TSX: QLT) announced today that QLT USA, ... license agreement with Reckitt Benckiser,Pharmaceuticals Inc. for its ... being retained by QLT USA and its,prior licensees. ... related asset,purchase agreement, QLT USA received an aggregate ...
... Susan G. Komen for the Cure(R), the,leader of ... organization,the Susan G. Komen for the Cure Advocacy ... about breast self awareness and the need for,increased ... and,underinsured., (Logo: http://www.newscom.com/cgi-bin/prnh/20070122/NYM084LOGO ), Komen ...
... -- Mindray,Medical International Limited (NYSE: MR ), ... in China, today released select historical,financial figures converted ... announced in May, 2008, Mindray changed its reporting ... effective April 1, 2008.,Accordingly, Mindray has issued these ...
... ATRC ), a medical device company and a ... will present at the following,investor conferences during September:, ... Four Seasons,Hotel in Boston on Wednesday, September 3, 2008. ... to present at 10:55,a.m. Eastern time., -- The ...
... docs to effectiveness of alternative therapies , , MONDAY, Aug. ... of antipsychotic drugs in seniors with dementia. But the ... a finding which suggests that warnings may not be ... Between late 2002 and June 2005, Health Canada issued ...
Cached Medicine News:Health News:LegalView Highlights Top Brain Injury Rehabilitation Hospitals in the United States - 5.3 Million Americans Suffer from TBI 2Health News:LegalView Highlights Top Brain Injury Rehabilitation Hospitals in the United States - 5.3 Million Americans Suffer from TBI 3Health News:LegalView Highlights Top Brain Injury Rehabilitation Hospitals in the United States - 5.3 Million Americans Suffer from TBI 4Health News:QLT announces agreement to exclusively license the Atrigel(R) Technology to Reckitt Benckiser Pharmaceuticals Inc. 2Health News:QLT announces agreement to exclusively license the Atrigel(R) Technology to Reckitt Benckiser Pharmaceuticals Inc. 3Health News:Komen Travels to Democratic Convention in Denver to Raise Awareness of Breast Cancer Issues 2Health News:Mindray Releases Historical Financial Results Converted into US Dollar Terms 2Health News:AtriCure to Participate at the Thomas Weisel Partners Healthcare Conference and the UBS Global Life Sciences Conference in September 2Health News:Antipsychotic Drug Use Up in Elderly Despite Warnings 2
(Date:12/24/2014)... Va. , Dec. 23, 2014  The ... diastolic blood pressure target for people with diabetes ... moderate or high doses of statins, in keeping ... management enacted by the American College of Cardiology ... are reflected in the most recent changes to ...
(Date:12/24/2014)... SANTA BARBARA, Calif. , Dec. 23, 2014 ... the Junior Doctors, Association of Sierra Leone ... Sierra Leone for the treatment of local ... While a new dedicated Ebola care center was ... Ebola virus, the facility is not available for local Sierra ...
(Date:12/24/2014)... , Dec. 23, 2014  Medical Science Liaisons play ... key link between the medical device industry and key ... in the coming years as the device industry relies ... According to research by benchmarking firm, Best Practices, LLC, ... an important edge is by harnessing new technology to ...
Breaking Medicine Technology:New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... transducer is a curved ... the higher frequencies. Featuring ... this transducer provides exceptional ... frequency abdominal kidney bladder ...
TOX/See is a 1-step, hand-held, point-of-care device for the qualitative detection of drug or drug metabolites in human urine....
Compact, bench-top analyser with minimal water volume requirements and easy waste management....
Compact benchtop clinical chemistry system...
Medicine Products: