Navigation Links
Genetic test would help 'cut bowel cancer spread'
Date:9/30/2014

Screening families of patients with bowel cancer for a genetic condition would cut their risk of developing bowel, womb, and ovarian cancers, new research has found.

In a major study, Dr Ian Frayling from Cardiff University's School of Medicine and researchers from the University of Exeter's Medical School assessed the effectiveness of introducing a UK-wide screening programme for a genetic condition known as Lynch Syndrome.

Lynch syndrome is a caused by changes in genes which check the spelling in DNA. The condition increases the risk of people developing cancer, particularly bowel cancer and cancers of the womb and ovaries later in life. Without testing cancers, it is not obvious that they are caused by Lynch syndrome, and so it is often not diagnosed.

It is responsible for around one in 12 cases of people aged under 50 and around a third of people with the disease develop bowel cancer by the time they are 70, if no action is taken.

"If Lynch Syndrome is identified as the cause of bowel cancer, patients can be offered risk-reducing measures such as more intensive post-operative colonoscopy surveillance to spot recurrences and new cancers early," according to Cardiff University's Dr Ian Frayling, the clinical adviser to the study.

"As close relatives have a 50 per cent chance of sharing the gene, screening would provide a valuable opportunity to detect the condition in children, siblings, parents and more distant relatives.

"It would mean measures could be taken to reduce the risk of cancers developing," he added.

The findings, published in Health Technology Assessment, indicate that screening the 1,700 people under the age of 50 who are newly diagnosed with bowel cancer (in England) each year would identify two thirds of these whose cancer was caused by Lynch Syndrome.

From this group, the findings suggest that 40 further cases of cancer could be avoided in them and their relatives.

Dr Frayling adds: "This is a very significant piece of work which is much to be welcomed.

"It justifies the National Health Services in the UK in implementing such testing, which is already carried out in other European countries.

"Those with Lynch Syndrome will now be found and given the care that they warrant, saving time, lives, money and resources. Colleagues around the world are eager to use the model developed by the University of Exeter's Medical School, so the benefits extend far beyond the UK."

The team systematically reviewed all the evidence surrounding Lynch Syndrome and bowel cancer, identifying and assessing 42 studies in total, before constructing a computer model of screening strategies for Lynch Syndrome.

It found that all screening strategies helped improve health outcomes at a cost generally acceptable to the NHS. The most cost-effective method of identifying Lynch Syndrome involved running tests on the tumour before offering counselling and genetic testing.

In a separate analysis, which has not yet been published or peer-reviewed, the team used the same model to estimate that 28 cancer related deaths (24 from bowel cancer and four from womb cancer) could be prevented each year if Lynch Syndrome screening for people with bowel cancer was introduced.

Dr Tristan Snowsill, of the University of Exeter's Medical School, said: "This is the first evidence that systematic testing for Lynch syndrome could be cost-effective in the NHS.

"There are health professionals in the NHS who think cost-effectiveness is the hurdle that needs to be cleared before systematic testing can be implemented; policymakers now have that evidence before them to decide if this is right for the NHS, a decision which will not be solely based on cost-effectiveness."

Deborah Alsina, Chief Executive of Bowel Cancer UK, commented: "We welcome these research findings which demonstrate that lives can be saved through earlier identification of those who are at higher risk of bowel cancer because of genetic conditions like Lynch syndrome.

"It's critical that more lives are saved by ensuring people gain access to the screening surveillance they need, so that bowel cancer can be ruled out first, not last, in younger patients.

"While bowel cancer is thankfully relatively rare in people under 50, there are still 550 people in this age group who lose their lives to bowel cancer each year and that must change."


'/>"/>

Contact: Chris Jones
jonesc83@cardiff.ac.uk
Cardiff University
@cardiffuni
Source:Eurekalert

Related medicine news :

1. Genetic test for cancer patients could be cost-effective and prevent further cases
2. Genetic modifier affects colon tumor formation
3. U-M, USC, Broad to study genetics of 2 mental health disorders
4. Number of Genetic Variants Linked to Prostate Cancer Increased from 77 To 100
5. National team awarded $16 million NIH grant to study genetics of schizophrenia and bipolar disorder
6. Genetic instruction set for antibodies knocks down hepatitis C in mice
7. Genetic, developmental and anatomical basis of natural selection for sensory structures
8. NYU-Mount Sinai Beth Israel study explores drug users opinions on genetic testing
9. Study uncovers genetic driver of inflammation, uses it to prevent and treat liver cancer
10. Environment plays bigger role than genetics in food allergic disease eosinophilic esophagitis
11. Melanoma risk found to have genetic determinant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... to the military at the same time by providing Prehospital Trauma Life Support ... PHTLS is the world’s premier prehospital trauma education developed in cooperation with the ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... from third world countries to hospitals in the United States, it’s a threat ... on the current obstacles facing infection prevention and offers strategies for the healthcare ...
(Date:3/24/2017)... ... , ... The Radiology Business Management Association (RBMA) has named the ... their 12th year, are among the most prestigious in radiology marketing because a panel ... retooled to recognize achievements in both large budget (over $5,000) and small budget (under ...
(Date:3/24/2017)... ... ... Texas Physical Therapy Specialists (TexPTS) is pleased to announce the opening ... is the group’s 7th location in San Antonio and 23rd in Texas. Dr. ... from the clinic, which opened March 22, 2017. , The team of ...
(Date:3/24/2017)... ... March 24, 2017 , ... Mlynarek Insurance Agencies, a Detroit ... business owners across eastern Michigan, is connecting with the Oxford/Orion FISH Food Pantry ... , The Oxford/Orion FISH Food Pantry works to ensure homeless, hungry, and underprivileged ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... 2017 Abdominal Aortic Aneurysm Repair Devices Market was valued at $1,844 ... a CAGR of 5.1% from 2016 to 2022. The endovascular stent graft system segment ... during the study period. Continue Reading ... ... ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... 2022" report to their offering. ... The global wound care market was worth $24,482.9 million in ... during 2016-2022 Among the various wound care products type, the ... market in 2015. Among the various applications, surgical wound segment held the ...
(Date:3/24/2017)... , March 24, 2017 ShangPharma, ... high-quality and cost-effective drug development and discovery ... and biotechnology industry, announced today the intent ... ShangPharma will be consolidating the Contract Research ... under Shanghai ChemPartner. These entities include ChemPartner ...
Breaking Medicine Technology: