Navigation Links
Genetic study sheds new light on auto-immune arthritis
Date:7/10/2011

The team of researchers from the Universities of Bristol, Queensland (Australia), Oxford, Texas and Toronto, used a technique called genome-wide association where millions of genetic markers are measured in thousands of people that have the disease and thousands of healthy individuals.

Markers which are more frequent in individuals with the disease are more likely to be involved in the condition.

Using this approach the investigators found an additional seven genes likely to be involved in the condition, bringing the total number of genes known to predispose to AS to thirteen. Many of the new genes are already known to be involved in inflammatory and immune processes, providing researchers with further clues about how the disease arises. Two of the new genes are also known to predispose to other auto-immune conditions including Crohn's disease (a form of inflammatory bowel disease) and Celiac disease (an auto-immune intestinal disease).

Researchers were also able to demonstrate an interaction between a genetic mutation called HLA-B27 and a mutation in a gene called ERAP1. Specifically, the ERAP1 mutation only predisposed to disease in those individuals who tested positive for the HLA-B27 mutation.

Dr David Evans from the University of Bristol said: "This finding is important in a number of ways. First of all it's one of the first convincing examples we have of one mutation influencing the effect of another mutation in the development of a relatively common disease. This is exciting because it implies that there may be other examples of this phenomenon in other common diseases that we don't know about yet.

"Second, the interaction itself tells us something very fundamental about how AS is caused. Prior to this study there were a number of competing theories about how the disease was caused. Our study suggests very strongly which one of these competing hypotheses is likely to be correct."

Finally, the rese
'/>"/>

Contact: Hannah Johnson
hannah.johnson@bristol.ac.uk
0044-117-928-8896
University of Bristol
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Obstructive Sleep Apnea in Kids May Have Genetic Cause
3. Epigenetic signals differ across alleles
4. Study reveals genetic link between mammographic density and breast cancer
5. Genetic Risk Score Doesnt Spot Heart Trouble in Women
6. Penn researchers find genetic link to leukemias with an unknown origin
7. Scientists Spot Genetic Fingerprints of Individual Cancers
8. Genetic health risks in children of assisted reproductive technology
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Protecting the brain from of a deadly genetic disease
11. Protecting the brain from a deadly genetic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... (PRWEB) December 25, 2014 Residents ... Retirement Community, recently showed their generous spirit by ... the Catawba County Parenting Network- Grandparents Raising Grandchildren ... children gathered around the largest Christmas tree on ... presents purchased by residents of the Abernethy Village ...
(Date:12/24/2014)... Over 700 toys, that’s what AlignLife clinics ... smiling little faces this holiday that might not have ... donations was given to the various charities as well ... through the year. Some of the charities chosen for ... Shrine's Children's Hospitals, Toys for Tots and Crisis Nurseries, ...
(Date:12/24/2014)... New York (PRWEB) December 24, 2014 ... mount in a mass tort litigation currently underway in ... reports. As of December 24, 2014, court documents ... proceeding on behalf of individuals who developed gynecomastia (male ... use. Data from the Court indicates that this represents ...
(Date:12/24/2014)... Today, UWDress.com, the famous women’s dress supplier, ... and launched a site-wide wedding gown promotion. , ... in a more unexpected way, the collection should be a ... the global market, and they are available with custom service. ... at discounted prices, up to 75% off; most of them ...
(Date:12/24/2014)... BambooIndustry.com a famous bamboo flooring company offering bamboo ... announces its multiple layer bamboo panel board collection ... products. , Bamboo panel is the product made from ... panel board features high quality selective bamboo and eco-friendly ... bamboo panel consists of multiple layers of bamboo. , ...
Breaking Medicine News(10 mins):Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:AlignLife Donates Over 700 Toys This Year 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4Health News:Buy Cheap Long Sleeve Wedding Gowns At UWDress.com 2Health News:Bamboo Flooring Company Bambooindustry.com Introduces Its Multiple Layer Bamboo Panel Board Collection 2
... ... 300,000 reported cases annually, sudden cardiac death (SCD) is the leading ... in previously asymptomatic individuals, SCD generally results in death within six minutes in ... only five percent of SCD victims survive. Contrary to common perception, SCD ...
... , SIOUX FALLS, S.D., Sept. 15 ... of media and connectivity solutions to hospitality and healthcare businesses, will ... the Omni Hotel in New York City on Thursday, September 17, ... strategy and its progress on its initiatives to proactively manage its ...
... MINNEAPOLIS, Sept. 15 Breast cancer is one ... times more likely to have,stage IV breast cancer at the ... some of the reasons why breast cancer is so,prevalent among ... to educate and reinforce the importance of early detection and,diagnosis ...
... One in eight women will be diagnosed with breast cancer ... be personally impacted by the disease*. Since there are no cures ... Dr. Kristi Funk are joining forces this September and October to ... risk, early detection and meaningful ways to support the cause. Founder ...
... Conn., Sept. 15 The Connecticut Department of Transportation would like ... celebrate International Walk to School Day on October 7, 2009 with ... contest. Students are challenged to walk or bike to and from ... who can be the first to walk or bike the distance ...
... , CHICAGO, Sept. 15 Advanced Life Sciences ... United States Food and Drug Administration (FDA) has granted Orphan ... antibiotic, for the prophylactic treatment of plague and tularemia. ... Disease Control as Category A Bioterrorism Agents, which is the ...
Cached Medicine News:Health News:Filmmaker John Hughes' Recent Untimely Death is a Call for Better Understanding ,of Sudden Cardiac Death, the Leading Cause of Natural Death in the U.S. 2Health News:Filmmaker John Hughes' Recent Untimely Death is a Call for Better Understanding ,of Sudden Cardiac Death, the Leading Cause of Natural Death in the U.S. 3Health News:Filmmaker John Hughes' Recent Untimely Death is a Call for Better Understanding ,of Sudden Cardiac Death, the Leading Cause of Natural Death in the U.S. 4Health News:Filmmaker John Hughes' Recent Untimely Death is a Call for Better Understanding ,of Sudden Cardiac Death, the Leading Cause of Natural Death in the U.S. 5Health News:Filmmaker John Hughes' Recent Untimely Death is a Call for Better Understanding ,of Sudden Cardiac Death, the Leading Cause of Natural Death in the U.S. 6Health News:LodgeNet Interactive to Present at the CL King Best Ideas Conference 2Health News:LodgeNet Interactive to Present at the CL King Best Ideas Conference 3Health News:LodgeNet Interactive to Present at the CL King Best Ideas Conference 4Health News:LodgeNet Interactive to Present at the CL King Best Ideas Conference 5Health News:Adamari Lopez & Yoplait(R) Committed to Continue Raising Awareness for Breast Cancer Risk Reduction Among the Hispanic Community 2Health News:Adamari Lopez & Yoplait(R) Committed to Continue Raising Awareness for Breast Cancer Risk Reduction Among the Hispanic Community 3Health News:Video: Yoplait(R) and Celebrity Breast Cancer Surgeon Dr. Kristi Funk Emphasize Importance of Early Detection and Risk Reduction 2Health News:Video: Yoplait(R) and Celebrity Breast Cancer Surgeon Dr. Kristi Funk Emphasize Importance of Early Detection and Risk Reduction 3Health News:Safe Routes to School Challenges Connecticut Students to Walk It and Bike It to School 2Health News:Advanced Life Sciences Announces Restanza(TM) Granted FDA Orphan Drug Designation for Plague and Tularemia 2Health News:Advanced Life Sciences Announces Restanza(TM) Granted FDA Orphan Drug Designation for Plague and Tularemia 3
(Date:12/24/2014)... -- Echo Therapeutics, Inc. (NASDAQ: ECTE ... permeation, continuous glucose monitoring and associated technologies, today ... been appointed Chief Executive Officer effective December 22, ... of experience in the medical device, pharmaceutical and ... Vice President, Business Development, Otsuka Pharmaceuticals as well as ...
(Date:12/24/2014)...   Assurex Health, a personalized medicine company ... for behavioral health and chronic pain conditions, today ... equity financing from new and existing investors, according ... Chief Executive Officer. The financing will ... Health,s GeneSight ®  products.  GeneSight,s patented ...
(Date:12/24/2014)... RALEIGH, N.C. , Dec. 23, 2014 ... plc (NASDAQ: ENDP ) (TSX: ENL), and ... announced today that they have submitted a New Drug ... U.S. Food and Drug Administration (FDA).  Buprenorphine HCl Buccal ... severe enough to require daily, around-the-clock, long-term opioid treatment ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5
The Atakr II RF Generator provides high power output with the integral safety of closed-loop temperature control using the embedded thermocouples in Medtronic RF ablation catheters....
... The R-F10 simplifies the standard ... degree - all operations in ... press of the Start button, ... entire series of steps for ...
... EP-X Single Plane Imaging System is the ... efficiency for the electrophysiology specialist. The EP-X ... a totally integrated and dedicated EP lab ... minimal space requirements and Pulsed Progressive Fluoroscopy ...
... Bi-Plane Electrophysiology imaging have become more acute. ... and reduce radiation exposure to both patient ... between Single and Bi-Plane systems. In ... leadership position in price/value relationship, four bi-plane ...
Medicine Products: