Navigation Links
Genetic study sheds new light on auto-immune arthritis
Date:7/10/2011

The team of researchers from the Universities of Bristol, Queensland (Australia), Oxford, Texas and Toronto, used a technique called genome-wide association where millions of genetic markers are measured in thousands of people that have the disease and thousands of healthy individuals.

Markers which are more frequent in individuals with the disease are more likely to be involved in the condition.

Using this approach the investigators found an additional seven genes likely to be involved in the condition, bringing the total number of genes known to predispose to AS to thirteen. Many of the new genes are already known to be involved in inflammatory and immune processes, providing researchers with further clues about how the disease arises. Two of the new genes are also known to predispose to other auto-immune conditions including Crohn's disease (a form of inflammatory bowel disease) and Celiac disease (an auto-immune intestinal disease).

Researchers were also able to demonstrate an interaction between a genetic mutation called HLA-B27 and a mutation in a gene called ERAP1. Specifically, the ERAP1 mutation only predisposed to disease in those individuals who tested positive for the HLA-B27 mutation.

Dr David Evans from the University of Bristol said: "This finding is important in a number of ways. First of all it's one of the first convincing examples we have of one mutation influencing the effect of another mutation in the development of a relatively common disease. This is exciting because it implies that there may be other examples of this phenomenon in other common diseases that we don't know about yet.

"Second, the interaction itself tells us something very fundamental about how AS is caused. Prior to this study there were a number of competing theories about how the disease was caused. Our study suggests very strongly which one of these competing hypotheses is likely to be correct."

Finally, the rese
'/>"/>

Contact: Hannah Johnson
hannah.johnson@bristol.ac.uk
0044-117-928-8896
University of Bristol
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Obstructive Sleep Apnea in Kids May Have Genetic Cause
3. Epigenetic signals differ across alleles
4. Study reveals genetic link between mammographic density and breast cancer
5. Genetic Risk Score Doesnt Spot Heart Trouble in Women
6. Penn researchers find genetic link to leukemias with an unknown origin
7. Scientists Spot Genetic Fingerprints of Individual Cancers
8. Genetic health risks in children of assisted reproductive technology
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Protecting the brain from of a deadly genetic disease
11. Protecting the brain from a deadly genetic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... Launch Corporation, LLC. is pleased to announce ... location at 17 Tanguay Avenue. Owned and operated by Rick ... Launch location in New England. , “We are extremely excited ... Arnold, founder, co-owner and CEO of Launch. “They have established ... to seeing them continue to establish that positive growth in ...
(Date:5/6/2015)... Charlotte, NC (PRWEB) May 06, 2015 ... Community Award of Charlotte in the small business category. ... , The Mayor’s International Community Award is given on ... Charlotte area that exhibit outstanding contributions to philanthropy. ... of the Mayor have hosted the Mayor’s International Community ...
(Date:5/6/2015)... 06, 2015 “ Radiation Island ” was ... takes a look at the latest and coolest applications on ... host of AppWatch and technology expert, conducted the app review ... best graphic games on iOS. , Touted as one of ... It’s loved by users, which is obvious because of its ...
(Date:5/5/2015)... With ProPoint: Hand Drawn, users can point, ... Pro X . With ProPoint: Hand Drawn, users can ... more customize each preset all with a click of a ... 90 fully customizable effect presets all within Final Cut Pro ... arrows, underlines, and more. , ProPoint: Hand Drawn on-screen ...
(Date:5/5/2015)... The Journal of Pain Research has ... improve the management of chronic non-cancer pain in ... program ” , As corresponding author Professor Lyne ... and family members, managers, and researcher, identified challenges ... “work in silos”, lack of awareness regarding chronic ...
Breaking Medicine News(10 mins):Health News:Jump Up and Celebrate: Launch Trampoline Park Opens in Nashua, NH 2Health News:LINET Americas Wins The Mayor's International Community Award in Charlotte 2Health News:Top Grossing iPhone Game, Radiation Island, Was Featured on NewsWatch 2Health News:FCPX Plugin Developer Pixel Film Studios release Propoint Hand Drawn 2Health News:Priority interventions in chronic non-cancer pain published by Dove Medical Press 2
... Flight West,(AFW) awarded The Distinguished Pilot of the Year ... 24th Anniversary Awards and on Saturday,November 17 at the ... missions over the past year. As an AFW pilot, ... require that they travel,to and from medical facilities and ...
... Testing, Improved Patient Privacy,Protections, LOS ANGELES, Nov. ... American Medical Association (AMA) for,recently updating its HIV ... and improved protection of patient privacy. According,to a ... HIV/AIDS Report, the,AMA,s new guidelines call for, "...physicians ...
... non-profit,organization Women in Government presented its Presidential Leadership,Award ... the John F.,Kennedy Center for the Performing Arts ... other states for launching a campaign to,"End Cervical ... accepted the award on behalf of the NLGA, ...
... The National Football,League Alliance Partnership recently kicked off ... for former NFL players. The program debuted ... Dr. Jeffrey Boone, founder of ProHeart MD, and ... a 64-slice CT scanner.,More than 30 NFL alumni ...
... 16 The President,s Council on,Physical Fitness and ... (APTA) as Science Partner on Friday, Nov 16, ... Arizona., "The President,s Council recognizes and values ... physical therapist practice," said,Melissa Johnson, executive director of ...
... Budget Office Data Finds Cuts Would,Jeopardize Health, Well-Being ... As Congress begins to,consider possible cuts to seniors, ... of Congressional Budget Office (CBO) data,finds five-year $2.7 ... onset of the,State Children,s Health Insurance Program (SCHIP) ...
Cached Medicine News:Health News:Angel Flight West Recognizes New Mexico Pilots and Receives Grant to Improve Access to Health Care 2Health News:AMA's New HIV Testing Guidelines Good for Public Health, Says AHF 2Health News:Broward Health and ProHeart MD Kick Off NFL Alumni Health Program 2Health News:American Physical Therapy Association Named Science Partner to the President's Council on Physical Fitness and Sports 2Health News:Medicare Cuts Pose Disproportionate Threat to Idaho's Rural Seniors, Local Jobs Base 2Health News:Medicare Cuts Pose Disproportionate Threat to Idaho's Rural Seniors, Local Jobs Base 3Health News:Medicare Cuts Pose Disproportionate Threat to Idaho's Rural Seniors, Local Jobs Base 4
(Date:5/5/2015)...  Trovagene, Inc. (NASDAQ:  TROV), a developer of ... for the three months ended March 31, 2015. ... presented favorable clinical results at ASCO GI, AACR, ... Precision Cancer Monitoring platform,s ability to detect and ... cancers," said Antonius Schuh, Ph.D., chief executive officer ...
(Date:5/5/2015)... YORK , May 5, 2015  IBM Watson ... is collaborating with more than a dozen leading cancer ... and personalize treatment options for their patients. The institutes ... capabilities to reduce from weeks to minutes the ability ... and gather relevant information from medical literature to personalize ...
(Date:5/5/2015)... Texas , May 5, 2015 ... valued at $94.9 million in 2014, and is estimated ... CAGR of 7.8% from 2014 to 2019. ... Surgery Device Market for an analysis of industry trends ... figures. http://www.micromarketmonitor.com/market/north-america-glaucoma-surgery-devices-8830146604.html ...
Breaking Medicine Technology:Trovagene, Inc. Announces First Quarter 2015 Financial Results 2Trovagene, Inc. Announces First Quarter 2015 Financial Results 3Trovagene, Inc. Announces First Quarter 2015 Financial Results 4Trovagene, Inc. Announces First Quarter 2015 Financial Results 5Trovagene, Inc. Announces First Quarter 2015 Financial Results 6Clinicians Tap Watson to Accelerate DNA Analysis and Inform Personalized Treatment Options for Patients 2Clinicians Tap Watson to Accelerate DNA Analysis and Inform Personalized Treatment Options for Patients 3Clinicians Tap Watson to Accelerate DNA Analysis and Inform Personalized Treatment Options for Patients 4Clinicians Tap Watson to Accelerate DNA Analysis and Inform Personalized Treatment Options for Patients 5Clinicians Tap Watson to Accelerate DNA Analysis and Inform Personalized Treatment Options for Patients 6North America Ophthalmology Glaucoma Surgery Device Market is Expected to Reach $138.3 Million by 2019, at a CAGR of 7.8% From 2014 to 2019 2North America Ophthalmology Glaucoma Surgery Device Market is Expected to Reach $138.3 Million by 2019, at a CAGR of 7.8% From 2014 to 2019 3
... ... ... ... keyed by longUrl, so we need to grab the first one. for (var r in data.results) { first_result = ...
... Generex Biotechnology Corporation (NasdaqCM: GNBT, www.generex.com ) today ... at the reconvened special meeting of stockholders being held ... proposal to adjourn the special meeting to Monday, October ... Generex,s proxy statement dated August 23, 2010, Generex received a ...
Cached Medicine Technology:Kibbutz Shamir and Essilor Sign Agreement 2Kibbutz Shamir and Essilor Sign Agreement 3Kibbutz Shamir and Essilor Sign Agreement 4Kibbutz Shamir and Essilor Sign Agreement 5Kibbutz Shamir and Essilor Sign Agreement 6Kibbutz Shamir and Essilor Sign Agreement 7Kibbutz Shamir and Essilor Sign Agreement 8Kibbutz Shamir and Essilor Sign Agreement 9Kibbutz Shamir and Essilor Sign Agreement 10Kibbutz Shamir and Essilor Sign Agreement 11Kibbutz Shamir and Essilor Sign Agreement 12Generex Announces That Adjournment Will be Sole Matter Considered at Reconvened Special Meeting of Stockholders on October 15, 2010 2Generex Announces That Adjournment Will be Sole Matter Considered at Reconvened Special Meeting of Stockholders on October 15, 2010 3Generex Announces That Adjournment Will be Sole Matter Considered at Reconvened Special Meeting of Stockholders on October 15, 2010 4Generex Announces That Adjournment Will be Sole Matter Considered at Reconvened Special Meeting of Stockholders on October 15, 2010 5Generex Announces That Adjournment Will be Sole Matter Considered at Reconvened Special Meeting of Stockholders on October 15, 2010 6
... Auto Suture™ Laparofan™ single-use laparoscopic fan ... surgery. It is indicated for endoscopic ... an alternative to insufflation., ,The ... is designed to be used in ...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
Ethicon Endo-Surgery provides disposable handheld instruments that provide reliable, precise performance every time. Our handheld instruments come in 5mm and 10mm sizes....
... The Auto Suture™ ... inclusive of five (5) ... application in a variety ... urologic, colorectal and other ...
Medicine Products: