Navigation Links
Genetic 'roadblock' hoped to inspire future type 2 diabetes research
Date:10/2/2007

Toronto, ON (October 2, 2007) A team of Mount Sinai Hospital researchers has found that a genetic roadblock identified in a recent study could pave the way toward novel treatments for type 2 diabetes.

In the study, researchers from the Samuel Lunenfeld Research Institute of Mount Sinai Hospital found the first genetic evidence that the elimination of the gene for glycogen synthase kinase-3 (GSK-3) in mice sensitizes the animals to insulin.

Insulin is a hormone that helps control sugar (glucose) levels in the blood. In people with type 2 diabetes, the pancreas does not produce enough insulin, or it is not properly used. As a result, sugar accumulates in the blood rather than being absorbed, stored or burned for energy. The study found that by eliminating GSK-3 in mouse models, more sugar became stored in the liver in response to increased insulin sensitivity, indicating that insulin had become more effective.

The study from the laboratory of Dr. Jim Woodgett, Director of the Lunenfeld, and the first scientist to isolate the GSK-3 genes in 1990, made the cover of the October 3 edition of Cell Metabolism.

We created a genetic roadblock by knocking out this particular gene and this made the mice far more efficient in their ability to use insulin to regulate their blood-sugar levels, said Dr. Woodgett. Research creates the best medicine and while potential human treatments are likely still years down the road, this study provides strong evidence that chemical inhibitors of this enzyme will be useful for increasing the effective potency of insulin.

The study was co-authored by Drs. Katrina MacAulay and Bradley Doble. Dr. MacAulay was inspired to become a medical researcher specializing in diabetes because her sister, Ailsa MacAulay, suffers from this disease.

I hope our findings will inspire other researchers around the world to develop treatments that will reduce symptoms of this epidemic disease as well
'/>"/>

Contact: Noemie Wiggett
nwiggett@mtsinai.on.ca
41-658-648-003-815
Samuel Lunenfeld Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Crowning glory of 2000!!! Cracking of the genetic code is top of tops
3. Genetic influence in menopause
4. Genetic differences found between Male and Female brains
5. Genetic Breakthrough in Common Eye Problem
6. Inflammatory bowel disease linked to genetic abnormality
7. Genetic Code Of C.difficile Cracked
8. Genetics and cholesterol levels
9. Genetics helps in attacking cancer
10. DNA biochip for genetic screening
11. Genetic disorder related with sleep patterns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... August 03, 2015 , ... Dignity Health named Dr. ... General Hospital Emergency Room – Gilbert, opening in August. The new facility is ... in the West Valley. , “Dr. Baldwin is an excellent leader and will ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... leading provider of medical information, risk management and investigative services, has introduced ... direction toward focused, expert information solutions that improve business outcomes for its ...
(Date:8/2/2015)... ... 03, 2015 , ... A new Phase I research study is looking at ... led by Kenneth G. Lucas, M.D. , chief of the division of pediatric ... at Kosair Children’s Hospital and in the UofL Department of Pediatrics ...
(Date:8/1/2015)... ... ... Back packs can be dangerous? Whaaat?! , Not the danger that guns ... a kid's spine. With school starting again, most kids will be asking for new ... aware of how to help them prevent injuries by understanding backpack safety. , "Carrying ...
(Date:8/1/2015)... , ... August 01, 2015 , ... Tina Wilcoxson, owner ... , Wilcoxson was given that honor by the National Retail Federation, the largest retail ... Wilcoxson was one of three Maine business owners to be named as such. According ...
Breaking Medicine News(10 mins):Health News:Dignity Health Names Dr. Norris A. Baldwin, Jr. Facility Medical Director of New Freestanding Emergency Room 2Health News:Dignity Health Names Dr. Norris A. Baldwin, Jr. Facility Medical Director of New Freestanding Emergency Room 3Health News:EMSI Announces New Branding: Powerful Information. Improved Outcomes. 2Health News:UofL Physicians Conducting Vaccine Trial for Children with Relapsed Tumors at Kosair Children’s Hospital 2Health News:Local AlignLife Doctor Donates Time to Check Back Packs 2Health News:Local Retail Advocate Wins National Recognition 2
... is an essential element of care for children requiring ... combining ketamine and propofol, two common medications used in ... it was unclear whether this practice was superior to ... Research led by Drs. Amit Shah, Gregory Mosdossy ...
... prostate cancer should be especially diligent about having routine ... at the University at Buffalo indicate. , Their findings ... more abnormal colon polyps, known as adenomas, and advanced ... of the research were presented Oct. 19 at a ...
... October 18, 2010 Neuralstem, Inc. (NYSE Amex: ... human clinical trial of the company,s spinal cord stem ... or Lou Gehrig,s disease) at Emory University in Atlanta, ... data from the first six non-ambulatory patients, the trial,s ...
... HealthDay Reporter , MONDAY, Oct. 18 (HealthDay ... victim to stunning medical mistakes, ranging from an operation ... for another patient, a new study finds. To ... Joint Commission in 2004 introduced a universal protocol for ...
... Mozes HealthDay Reporter , MONDAY, Oct. 18 (HealthDay ... may raise the risk for heart attack and stroke, researchers ... short-term, the study team noted. "I don,t want to ... cardiovascular risk in the period just after dental work was ...
... likely to buy unhealthy foods when they pay using ... in the Journal of Consumer Research . ... authors Manoj Thomas (Cornell University), Kalpesh Kaushik Desai (State ... University of New York, Buffalo). "First, there is a ...
Cached Medicine News:Health News:Study reveals superior sedation method for children 2Health News:Prostate cancer patients are at increased risk of precancerous colon polyps 2Health News:Neuralstem updates ALS clinical trial progress 2Health News:Surgery on Wrong Patients, Surgical Sites Persists, Study Finds 2Health News:Surgery on Wrong Patients, Surgical Sites Persists, Study Finds 3Health News:Surgery on Wrong Patients, Surgical Sites Persists, Study Finds 4Health News:Invasive Dentistry May Raise Short-Term Heart, Stroke Risk 2Health News:Invasive Dentistry May Raise Short-Term Heart, Stroke Risk 3Health News:Cash is healthier? Credit and debit increase impulsive food purchases 2
(Date:7/30/2015)... -- PTC Therapeutics, Inc. (NASDAQ: PTCT ) today ... the second quarter ending June 30, 2015. ... organization.  We are excited to be near the completion ... conducted with topline results expected in the fourth quarter," ... Therapeutics, Inc. "Translarna is now commercially available in 12 ...
(Date:7/30/2015)... 30, 2015 Tianyin Pharmaceutical Inc. (NYSE Amex: ... specializes in the patented biopharmaceutical, modernized traditional Chinese medicine ... updates regarding the notice it received on May 21, ... that the Company was below certain of the Exchange,s ... and 1101 of the NYSE MKT Company Guide, due ...
(Date:7/30/2015)... LAKE, N.J. , July 30, 2015 ... simultaneously in the United States , ... the FDA, EMA and MHLW, respectively) for eribulin, for ... (STS) who have received prior chemotherapy for advanced or ... based on data from a pivotal global Phase 3 ...
Breaking Medicine Technology:PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 10TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 3Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 4Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 5
... 27, 2011 Water Street Healthcare Partners , ... care, announced today that it has acquired MarketLab, ... firm,s fourth in the specialty healthcare distribution sector.  The ... companies specializing in distribution, life sciences, medical devices and ...
... 2011 Pacira Pharmaceuticals, Inc ., (Nasdaq: ... announced that it has been included in the Russell ... set of U.S. and global equity indexes on June ... measures the performance of the 3,000 largest U.S. companies ...
Cached Medicine Technology:Water Street Healthcare Partners Acquires MarketLab, Inc. 2Water Street Healthcare Partners Acquires MarketLab, Inc. 3Pacira Pharmaceuticals, Inc. Announces Inclusion in Russell 3000 Index 2Pacira Pharmaceuticals, Inc. Announces Inclusion in Russell 3000 Index 3
... Isolation Kit (patent pending) is designed for ... / or Newcastle Disease (ND) viral RNA ... samples. This kit id validated by the ... their testing protocol for real-time RT-PCR detection ...
... This revolutionary product will provide ... any type of electroretinogram, visual evoked ... LED ganzfeld will allow you to ... including on-off, double flash, photopic negative ...
... LABOTECH is an automated microplate ... immunoenzymatic microplate techniques. Open architecture ... to many manufacturers' microplate assays ... traditional R.I.A. and I.F.A. methods ...
The Rapidpoint 400/405 instrument is a point-of-care blood gas analyzer that's fast, easy to operate and reliable....
Medicine Products: