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Genetic risk strategies needed for young, black, female breast cancer patients, Moffitt study shows
Date:3/21/2013

a counties between 2005 and 2006 and conducted BRCA testing in 46 participants.

Participants and nonparticipants were similar in clinical and sociodemographic characteristics, suggesting that a representative sample was recruited, enhancing the generalizability of findings, the researchers reported. All participants received telephone-based pre-test genetic counseling during which a three-generation family history was generated.

"Through our study, we determined that 34 participants met national guidelines for BRCA testing, but only 13 reported that their health care providers referred them for genetic counseling and/or testing," Pal said. "A genetic evaluation is important in at-risk women, and is important for decision-making in the pre-surgical setting for patients, due to the high risk for second primary breast cancer in those with BRCA mutations."

Analysis also found that among BRCA mutation carriers, there was an association between those who chose bilateral mastectomy and with those with a family history of breast cancer and higher household income. The researchers noted that the association between bilateral mastectomy and family history suggests that genetic information may be considered by patients and providers when deciding on type of surgery, despite lack of referral for genetic counseling and consideration of BRCA testing. Interestingly, said the researchers, bilateral mastectomy was more common in those with higher incomes, and further study into this association is warranted.

"Our study found that the BRCA mutation prevalence in younger black women is similar to previous studies, yet our findings demonstrated that the majority are not referred for genetic counseling and/or BRCA testing, despite most meeting national practice guidelines for BRCA testing," Vadaparampil said. "This may represent a missed clinical opportunity."

The researchers have used their study as the foundation for additional outreach
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Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

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