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Genetic risk strategies needed for young, black, female breast cancer patients, Moffitt study shows
Date:3/21/2013

Researchers at Moffitt Cancer Center and colleagues in Canada have published study results focused on black women younger than 50, a population disproportionately afflicted with and dying from early-onset breast cancer compared to their white counterparts. The research published in the Jan. 16 issue of The Breast Journal.

Early-onset breast cancer has been associated with mutations in the BRCA1 and BRCA2 genes. These breast cancer predisposing genes were discovered almost 20 years ago and confer a lifetime risk of breast cancer of 60 to 70 percent, as well as a much higher risk of a second primary breast cancer compared to noncarriers. The researchers suggest that genetic counseling and BRCA testing can reduce cancer incidence and mortality in those identified with mutations.

"We need to better understand why black women develop early-onset, aggressive disease," said study co-author Tuya Pal, M.D., associate member of the Cancer Epidemiology Program at Moffitt. "More research may be needed to help us develop strategies to reduce this disparity."

According to prior studies, few young black women undergo genetic testing, despite the known association between BRCA mutations and breast cancer. And when black women develop breast cancer, their family history and financial status may influence their treatment choices, such as bilateral mastectomy surgery to prevent future cancer.

"Black women continue to be underrepresented in studies of the genetic causes of breast cancer," said study co-author Susan T. Vadaparampil, Ph.D., M.P.H., a behavioral scientist in the Health Outcomes and Behavior Program at Moffitt. "However, our efforts in the state of Florida demonstrate that these women are willing to participate in studies focused on the genetic causes of cancer."

Their study, carried out using the Florida state cancer registry, surveyed black women 50 and younger with breast cancer who resided in one of four Florid
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Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

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