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Genetic risk factors play role in autoantibody-negative rheumatoid arthritis
Date:4/7/2009

ce most RA patients fall into this group. The authors suggest that new studies that incorporate more ACPA-negative patients will show that these risk factors also predispose individuals to this form of the disease.

The known risk factors for ACPA-negative disease do not confer as high a risk of developing RA as the HLA SE alleles. In light of the finding of the similar heritability of ACPA-positive and ACPA-negative RA, the authors conclude: "This means that genetic predisposition also plays an important role in the pathogenesis of ACPA-negative RA, for which most individual genetic risk factors remain to be identified."


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